UBE2E3
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Official Full Name
ubiquitin-conjugating enzyme E2E 3
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Overview
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein shares 100% sequence identity with the mouse and rat counterparts, which indicates that this enzyme is highly conserved in eukaryotes. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. -
Synonyms
UBE2E3; ubiquitin-conjugating enzyme E2E 3; ubiquitin conjugating enzyme E2E 3 (homologous to yeast UBC4/5) , ubiquitin conjugating enzyme E2E 3 (UBC4/5 homolog, yeast); ubiquitin-conjugating enzyme E2 E3; UbcH9; ubiquitin-protein ligase E3; ubiquitin ca;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- Insect Cell
- Mammalian Cell
- GST
- His
- His (Fc)
- Avi
- Strep
- N/A
- No tag
- Involved Pathway
- Protein Function
- Interacting Protein
- UBE2E3 Related Research Area
UBE2E3 involved in several pathways and played different roles in them. We selected most pathways UBE2E3 participated on our site, such as Adaptive Immune System, Antigen processing: Ubiquitination &, Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with UBE2E3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Adaptive Immune System | ITGB1B.1;DCTN2;DCTN1;KLRB1F;RAP1GAP2;KIF15;KIF22;LILRB5;RASGRP1 |
| Antigen processing: Ubiquitination & | ASB13;NPEPPS;PJA2;ATG7;KLHL21;UBE2E3;ASB2;WWP1;MKRN1 |
| Proteasome degradation | ASB14;DZIP3;TRAF7;UBE2V1;TRIM39;RBCK1;RNF123;SPSB1;UBR2 |
| Class I MHC mediated antigen processing & | ASB17;UBA5;UBR2;PJA1;UBE2F;ATG7;ASB13;LTN1;RNF25 |
| presentation | SH3RF1;RBCK1;UBR1;RNF111;PJA1;CMTM2A;TRIM50;SEC23A;SPSB2 |
| Immune System | DYNC1I1;PVRL2L;LILRB1;KIR2DS2;KIF4A;KIFAP3;SAMHD1;TREML2;TREML1 |
| Protein processing in endoplasmic reticulum | FBXO2;VIMP;XBP1;EDEM1;CAPN2B;HSP90AA1.2;CUL1A;SEC63;SEC31A |
| Ubiquitin mediated proteolysis | KLHL13;UBE2L3B;CUL4B;SIAH1;UBOX5;ANAPC7;RHOBTB2A;SYVN1;UBE2N |
| protein ubiquitylation | UBE2E3;UEVLD;UBE2U;UBA5;RNF216 |
UBE2E3 has several biochemical functions, for example, ATP binding, protein binding, ubiquitin conjugating enzyme activity. Some of the functions are cooperated with other proteins, some of the functions could acted by UBE2E3 itself. We selected most functions UBE2E3 had, and list some proteins which have the same functions with UBE2E3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | HSP104;ENTPD8;MYO6B;CKBA;EHD3;EIF4A2;ABCD4;ATP11C;TNK2B |
| protein binding | DUSP2;RPP38;ATL2;TRIM17;DSCC1;POLR3C;SETBP1;ERLEC1;ENPP1 |
| ubiquitin conjugating enzyme activity | CDC34;UBE2O;UBE2QL1;UBE2D4;UBE2G1;UBE2D2;UBE2Z;UBE2Q2;UBE2D3 |
| ubiquitin-protein transferase activity | NLRC4;UBE2D4;BIRC5A;RNF213;RNF152;TRIM9;UBE2O;FEM1B;UBE2W |
UBE2E3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UBE2E3 here. Most of them are supplied by our site. Hope this information will be useful for your research of UBE2E3.
RNF5; MID1; RNF185; TRIM39; RNF111; RNF25
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