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Official Full Name ubiquitin-conjugating enzyme E2E 3
Background The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein shares 100% sequence identity with the mouse and rat counterparts, which indicates that this enzyme is highly conserved in eukaryotes. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.
Synonyms UBE2E3; ubiquitin-conjugating enzyme E2E 3; ubiquitin conjugating enzyme E2E 3 (homologous to yeast UBC4/5) , ubiquitin conjugating enzyme E2E 3 (UBC4/5 homolog, yeast); ubiquitin-conjugating enzyme E2 E3; UbcH9; ubiquitin-protein ligase E3; ubiquitin ca
    • Species :
    • Chicken
    • Human
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human UBE2E3-112H Recombinant Human UBE2E3, His-tagged E.coli His
    Human UBE2E3-31658TH Recombinant Human UBE2E3 N/A
    Human UBE2E3-3532H Recombinant Human UBE2E3, GST-tagged E.coli GST
    Human UBE2E3-580HCL Recombinant Human UBE2E3 293 Cell Lysate HEK293 N/A
    Human UBE2E3-581HCL Recombinant Human UBE2E3 293 Cell Lysate HEK293 N/A
    Human UBE2E3-647H Recombinant Human UBE2E3 Protein, His-tagged, Active E.coli His
    Rhesus Macaque UBE2E3-5058R Recombinant Rhesus monkey UBE2E3 Protein, His-tagged Mammalian Cell His
    Chicken UBE2E3-4135C Recombinant Chicken UBE2E3 Mammalian Cell His
    Zebrafish UBE2E3-11162Z Recombinant Zebrafish UBE2E3 Mammalian Cell His

    ube2e3 involved in several pathways and played different roles in them. We selected most pathways ube2e3 participated on our site, such as Adaptive Immune System, Antigen processing: Ubiquitination &amp, Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with ube2e3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Adaptive Immune System SH2D1B; CD300LF; AP2S1; AP1B1; UBR2; TREM1; STIM1B; FBXO44; PJA2; SPSB1
    Antigen processing: Ubiquitination &amp ASB3; LRR1; ASB14; RNF19B; UBE2V2; TRIM39; ASB8; CMTM2A; FBXO44; PJA2
    Proteasome degradation LRR1; SPSB1; PJA1; ASB2; LTN1; FBXO44; UBE2E3; SPSB2; DTX3L; ASB13
    Class I MHC mediated antigen processing &amp RNF4; SPSB4; CYBA; LTN1; ASB14; TRIM41; UBE2L6; SH3RF1; UBE2U; LRR1
    presentation UBE2F; TRIM63; PJA1; UBE2L6; UBE2V1; SPSB4; CYBB; RNF6; RNF14; TRIM50
    Immune System S100B; PJA1; POLR3GLA; GZMM; EIF4G2A; DEFB129; DEFB116; CTSH; NLRP4B; LRRC41
    Protein processing in endoplasmic reticulum NGLY1; MAPK8A; DNAJC3; VCP; MAN1A; SEC13; BAX; UBQLN4; PDIP5; RRBP1B
    Ubiquitin mediated proteolysis UBA6; BTRC; COP1; PIAS4; UBE2K; UBA1; XIAP; UBE2D1B; SKP1; ANAPC11
    protein ubiquitylation RNF216; UEVLD; UBA5; UBE2E3; UBE2U

    ube2e3 has several biochemical functions, for example, ATP binding, protein binding, ubiquitin conjugating enzyme activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ube2e3 itself. We selected most functions ube2e3 had, and list some proteins which have the same functions with ube2e3. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding PTK2AA; ACVR2A; ABCG2D; TOR1B; HK2; CDK15; PSMC2; UBE2Q2; OASL1; SCN8A
    protein binding PTPN6; RUSC2; COPS7A; EXO1; SREBF1; NRG4; ARNTL; STX11; HSPA13; GATA1A
    ubiquitin conjugating enzyme activity UBE2J2; UBE2E1; UBE2G1; UBE2D1; UBE2Z; UBE2QL1; UBE2D4; UBE2V2; UBE2J1; UBE2H
    ubiquitin-protein transferase activity UBE2S; TRAF4A; FBXL5; G2E3; UBE2T; RNF152; MARCH5L; SIAH2L; TRIM13; FBXL14A

    ube2e3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ube2e3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ube2e3.

    RNF5; MID1; RNF185; TRIM39; RNF111; RNF25

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