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UBE2L6

  • Official Full Name

    ubiquitin-conjugating enzyme E2L 6

  • Overview

    The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is highly similar in primary structure to the enzyme encoded by the UBE2L3 gene. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
  • Synonyms

    UBE2L6; ubiquitin-conjugating enzyme E2L 6; ubiquitin/ISG15-conjugating enzyme E2 L6; UBCH8; ubiquitin-protein ligase L6; ubiquitin carrier protein L6; retinoic acid induced gene B protein; retinoic acid-induced gene B protein; RIG-B; MGC40331;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • Insect Cell
  • Mammalian Cell
  • C
  • Myc
  • DDK
  • GST
  • His
  • His (Fc)
  • Avi
  • Strep
  • N/A
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human UBE2L6-928H Active Recombinant Human UBE2L6 Protein, GST-tagged E.coli GST
Human UBE2L6-929H Active Recombinant Human UBE2L6 E.coli N/A
Human UBE2L6-30H Recombinant Human Ubiquitin-Conjugating Enzyme E2L6, His-tagged E.coli His
Human UBE2L6-3539H Recombinant Human UBE2L6, GST-tagged E.coli GST 1-153aa
Human UBE2L6-134H Recombinant Human UBE2L6 E.coli N/A
Human UBE2L6-7340H Recombinant Human Ube2L6 protein, His-tagged E.coli His Met1-Ser153
Human UBE2L6-31251TH Recombinant Human UBE2L6, His-tagged E.coli His
Human UBE2L6-568HCL Recombinant Human UBE2L6 293 Cell Lysate HEK293 N/A
Human UBE2L6-569HCL Recombinant Human UBE2L6 293 Cell Lysate HEK293 N/A
Human UBE2L6-649H Recombinant Human UBE2L6 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human UBE2L6-0230H Recombinant Human UBE2L6 Protein (M2-S153), Tag Free Insect Cell No tag M2-S153
Human UBE2L6-0231H Recombinant Human UBE2L6 Protein (M2-S153), His/Strep tagged Insect Cell His/Strep M2-S153
Human UBE2L6-145H Recombinant Human UBE2L6 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Mouse UBE2L6-17724M Recombinant Mouse UBE2L6 Protein Mammalian Cell His
Mouse Ube2l6-6793M Recombinant Mouse Ube2l6 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse UBE2L6-9833M Recombinant Mouse UBE2L6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse UBE2L6-9833M-B Recombinant Mouse UBE2L6 Protein Pre-coupled Magnetic Beads HEK293
Rat UBE2L6-6402R Recombinant Rat UBE2L6 Protein Mammalian Cell His
Rat UBE2L6-6058R Recombinant Rat UBE2L6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat UBE2L6-6058R-B Recombinant Rat UBE2L6 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • UBE2L6 Related Research Area

UBE2L6 involved in several pathways and played different roles in them. We selected most pathways UBE2L6 participated on our site, such as Adaptive Immune System, Antigen processing: Ubiquitination &amp, Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with UBE2L6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Adaptive Immune SystemUBE2E3;FRS2;CD200R4;KLRB1B;CD300LD;STIM1B;TPP2;RASGRP1;AP2A1
Antigen processing: Ubiquitination &ampUBE2F;LRRC41;ARIH2;TRIM63;UBE2V1;ATG7;ASB17;RNF123;FBXO17
Proteasome degradationUBE2J2;RNF144B;ASB11;RNF34;TPP2;RBCK1;TRIM63;WSB1;STUB1
Antiviral mechanism by IFN-stimulated genesEIF4G2;EIF4G1;IFIT11;DPF1;EIF4A2;IFIT14;NUP50;EIF4G2A;IFIT8
Class I MHC mediated antigen processing &ampFBXO17;RNF123;B2ML;TRIM9;LTN1;PJA1;FBXO3;LRRC41;ARIH2
presentationRNF111;ASB2;UBE2V1;UBR1;FCGR1B;FBXO27;UBE2L6;CTSL2;STUB1
Cytokine Signaling in Immune systemHAVCR2;IFITM3;CSF2;LGALS9;PELI3;TRIM38;ISG20;TRIM14;OASL
DNA Damage BypassDDB1;USP43;RAD18;SPRTN;UBE2L6;USP10;POLI;DTL;MAD2L2
DNA RepairCOPS2;TDP2;COPS4;TP53BP1;COPS3;KDM4B;NFRKB;DDB1;ASCC3
ISG15 antiviral mechanismKPNA3;IFIT11;EIF4G2A;UBE2L6;IFIT14;EIF4G2;HERC5;KPNA4;MX2

UBE2L6 has several biochemical functions, for example, ISG15 transferase activity, protein binding, ubiquitin-protein transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by UBE2L6 itself. We selected most functions UBE2L6 had, and list some proteins which have the same functions with UBE2L6. You can find most of the proteins on our site.

Function Related Protein
ISG15 transferase activityUBE2E1;UBE2L6;HERC5;UBE2E2
protein bindingHPCAL4;CTSG;CLEC7A;FBXO34;FER;ADAMTS5;ELANE;FDX1L;TMEM64
ubiquitin-protein transferase activityHERC2;FBXO3;TRAF2;TRAF3;NEDD4L;FBXW11;RNF10;TRIP12;RNF6

UBE2L6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UBE2L6 here. Most of them are supplied by our site. Hope this information will be useful for your research of UBE2L6.

ARIH2; RNF144B; LONRF1; RBCK1; RNF19B

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