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Official Full Name ubiquitin-conjugating enzyme E2L 6
Background The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is highly similar in primary structure to the enzyme encoded by the UBE2L3 gene. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Synonyms UBE2L6; ubiquitin-conjugating enzyme E2L 6; ubiquitin/ISG15-conjugating enzyme E2 L6; UBCH8; ubiquitin-protein ligase L6; ubiquitin carrier protein L6; retinoic acid induced gene B protein; retinoic acid-induced gene B protein; RIG-B; MGC40331
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Tag :
    • C-Myc/DDK
    • GST
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human UBE2L6-134H Recombinant Human UBE2L6 E.coli N/A
    Human UBE2L6-145H Recombinant Human UBE2L6 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
    Human UBE2L6-30H Recombinant Human Ubiquitin-Conjugating Enzyme E2L6, His-tagged E.coli His
    Human UBE2L6-31251TH Recombinant Human UBE2L6, His-tagged E.coli His
    Human UBE2L6-3539H Recombinant Human UBE2L6, GST-tagged E.coli GST
    Human UBE2L6-568HCL Recombinant Human UBE2L6 293 Cell Lysate HEK293 N/A
    Human UBE2L6-569HCL Recombinant Human UBE2L6 293 Cell Lysate HEK293 N/A
    Human UBE2L6-649H Recombinant Human UBE2L6 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human UBE2L6-7340H Recombinant Human UBE2L6, His tagged E.coli His
    Human UBE2L6-928H Recombinant Human UBE2L6 Protein, GST-tagged E.coli GST
    Human UBE2L6-929H Recombinant Human UBE2L6 E.coli N/A
    Mouse UBE2L6-17724M Recombinant Mouse UBE2L6 Protein Mammalian Cell His
    Mouse Ube2l6-6793M Recombinant Mouse Ube2l6 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Rat UBE2L6-6402R Recombinant Rat UBE2L6 Protein Mammalian Cell His

    ube2l6 involved in several pathways and played different roles in them. We selected most pathways ube2l6 participated on our site, such as Adaptive Immune System, Antigen processing: Ubiquitination &amp, Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with ube2l6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Adaptive Immune System SIGLEC7; FRS2B; TRAT1; AP1M2; SIGLEC8; OSBPL1A; SIGLEC10; RNF182; UBE2E3; PJA1
    Antigen processing: Ubiquitination &amp RNF144B; FBXO27; SPSB2; RNF14; RNF25; ASB4; LRSAM1; VPRBP; UFL1; CMTM2A
    Proteasome degradation HECTD3; UFL1; UBE2J2; UBR1; ASB18; RBCK1; BLMH; LRRC41; ARIH2; WSB1
    Antiviral mechanism by IFN-stimulated genes DPF1; HERC5; KPNA3; MX2; NUP35; ARIH1L; KPNA5; EIF4A1; IFIT12; IFIT10
    Class I MHC mediated antigen processing &amp CMTM2A; WSB1; ERAP1; RNF19B; UBE2L6; KLHL21; ASB18; RNF6; NPEPPS; ASB10
    presentation RNF144B; UBE2U; FBXO17; ASB14; RNF6; ASB17; RNF19B; TRIM50; SPSB4; RBCK1
    Cytokine Signaling in Immune system CSK; IL1RN; FRS2B; OSTN; GBP6; CRK; EIF4E; KLB; NRG2A; ARIH1L
    DNA Damage Bypass UBE2L6; USP43A; USP43; ZBTB32; RAD18; SPRTN; POLD3; KIAA0101; DTL; USP10
    ISG15 antiviral mechanism KPNA3; ARIH1L; MX2; EIF4G2; IFIT11; USP18; IFIT14; ARIH1; IFIT10; IFIT12

    ube2l6 has several biochemical functions, for example, ISG15 transferase activity, protein binding, ubiquitin-protein transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ube2l6 itself. We selected most functions ube2l6 had, and list some proteins which have the same functions with ube2l6. You can find most of the proteins on our site.

    Function Related Protein
    ISG15 transferase activity UBE2E2; UBE2L6; UBE2E1; HERC5
    protein binding HEBP2; CTSZ; ARPC5; CEBPG; NAPG; ACY3; MTOR; SENP1; CHMP2B; PCGF2
    ubiquitin-protein transferase activity RNF43; HECTD1; TRAF4B; FBXL3; UBE3C; UBE2L3; ARIH2; TRAF4A; PJA2; ARIH1

    ube2l6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ube2l6 here. Most of them are supplied by our site. Hope this information will be useful for your research of ube2l6.


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