UBE2N
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Official Full Name
ubiquitin-conjugating enzyme E2N
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Overview
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived;proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or;E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the;E2 ubiquitin-conjugating enzyme family. Studies in mouse suggest that this protein plays a role in DNA postreplication;repair. -
Synonyms
UBE2N; ubiquitin-conjugating enzyme E2N; ubiquitin conjugating enzyme E2N (homologous to yeast UBC13) , ubiquitin conjugating enzyme E2N (UBC13 homolog, yeast); ubiquitin-conjugating enzyme E2 N; MGC8489; UBC13; UbcH ben; yeast UBC13 homolog; ubiquitin-p;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Cynomolgus Monkey
- Human
- Mouse
- Rat
- Rhesus Macaque
- E.coli
- HEK293
- HEK293T
- Insect Cell
- Mammalian Cell
- GST
- His
- His (Fc)
- Avi
- Strep
- Myc
- DDK
- N/A
- No tag
- Involved Pathway
- Protein Function
- Interacting Protein
- UBE2N Related Research Area
UBE2N involved in several pathways and played different roles in them. We selected most pathways UBE2N participated on our site, such as Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with UBE2N were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ubiquitin mediated proteolysis | UBE4A;UBA6;FANCL;UBE2D1;PRPF19;ANAPC4;UBE2H;CUL1;COP1 |
UBE2N has several biochemical functions, for example, ATP binding, poly(A) RNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UBE2N itself. We selected most functions UBE2N had, and list some proteins which have the same functions with UBE2N. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | ABCA7;PGK2;DHX58;RNASEL;KDR;CDC42BPA;HSPA1L;ACTC1B;GATB |
| poly(A) RNA binding | RPSA;RBMS1;APEX1;NSUN2;ZNF207;EXOSC10;LRPPRC;SPATS2L;PRKDC |
| protein binding | C9orf86;TAB2;LONRF3;ZFYVE1;ASCC1;COPS7A;PIK3R4;SKA3;EIF2B3 |
| ubiquitin binding | FAN1;UBXN11;C6orf106;FAF2;RNF168;UBXN2B;UBXN2A;CRY2;UCHL3 |
| ubiquitin conjugating enzyme activity | UBE2QL1;UBE2E2;UBE2V1;UBE2R2;UBE2Q2;UBE2D2A;UBE2D1;UBE2T;UBE2D4 |
| ubiquitin protein ligase activity | UBE2N;RNF149;TRIM72;CBL;NEURL3;HERC5;UBE2R2;TRAIP;RAD18 |
| ubiquitin protein ligase binding | CUL4A;PRR5L;NPLOC4;TCEB2;USP25;MYOD1;GPI1;TNFRSF1B;TRAF6 |
| ubiquitin-protein transferase activity | SIAH1;RNF125;UBE2K;TRIM9;BIRC5A;FBXL14A;UBR4;HACE1;UHRF2 |
UBE2N has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UBE2N here. Most of them are supplied by our site. Hope this information will be useful for your research of UBE2N.
UBE2V1; STUB1
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