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Official Full Name ubiquitin-conjugating enzyme E2 variant 1
Background Has no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through Lys-63. This type of poly-ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF-kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage.
Synonyms UBE2V1; ubiquitin-conjugating enzyme E2 variant 1; UBE2V; CROC 1; CROC1; UEV 1; UEV1A; DNA-binding protein; TRAF6-regulated IKK activator 1 beta Uev1A; CIR1; UEV1; UEV-1; CROC-1;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Tag :
    • GST
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human UBE2V1-109H Recombinant Human UBE2V1 protein, His-tagged E.coli His
    Human UBE2V1-3548H Recombinant Human UBE2V1, GST-tagged E.coli GST
    Human UBE2V1-560HCL Recombinant Human UBE2V1 293 Cell Lysate HEK293 N/A
    Mouse Ube2v1-6800M Recombinant Mouse Ube2v1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Rhesus Macaque UBE2V1-5068R Recombinant Rhesus monkey UBE2V1 Protein, His-tagged Mammalian Cell His
    Chicken UBE2V1-4508C Recombinant Chicken UBE2V1 Mammalian Cell His
    Zebrafish UBE2V1-3527Z Recombinant Zebrafish UBE2V1 Mammalian Cell His

    ube2v1 involved in several pathways and played different roles in them. We selected most pathways ube2v1 participated on our site, such as Activated TLR4 signalling, Adaptive Immune System, Antigen processing: Ubiquitination &amp, which may be useful for your reference. Also, other proteins which involved in the same pathway with ube2v1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Activated TLR4 signalling NOD1; PELI2; JUN; ATF2; TAB1; APPB; SAA1; MAP3K8; CHUK; TICAM1
    Adaptive Immune System CTSH; FAM49BA; UBE2F; RNF220; EGF; CD300LD; TREML1; CLEC2B; CTSK; RNF19B
    Antigen processing: Ubiquitination &amp SPSB1; RNF25; NPEPPS; ASB17; RNF220; TRIM50; RNF14; KLHL20; SH3RF1; TRAF7
    Proteasome degradation CMTM2A; RNF6; FBXO3; RNF4; RNF220; LTN1; RNF182; LRRC41; SPSB4; UBE2V1
    C-type lectin receptors (CLRs) CLEC6A; TAB1; AHCYL1; ITPR2; CLEC4A; UBE2V1; CLEC4D; MALT1; CASP8L1; IL1B2
    CLEC7A (Dectin-1) signaling MALT1; UBE2V1; AHCYL1; TAB1; CASP8L1; IL1B2
    Class I MHC mediated antigen processing &amp UBE2F; SPSB4; SEC61B; ASB9; LRRC41; TRIM11; PJA1; WSB1; RNF6; RNF182
    presentation ERAP2; TRIM9; ASB11; SEC24A; RNF34; TRIM11; SEC61B; ASB7; ASB18; TRIM63
    Cytokine Signaling in Immune system LGALS9; DUSP2; MAP3K8; CSK; GBP4; PRLRB; GBP5; UBE2V1; CISH; JAK3
    Downstream TCR signaling TRAT1; HLA-DQB2; UBE2V1

    ube2v1 has several biochemical functions, for example, protein binding, ubiquitin conjugating enzyme activity, ubiquitin conjugating enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ube2v1 itself. We selected most functions ube2v1 had, and list some proteins which have the same functions with ube2v1. You can find most of the proteins on our site.

    Function Related Protein
    protein binding CCDC6; TREML1; DDRGK1; PPAP2B; PARD6A; ERCC3; CCL20; CENPP; TTC1; GLUD1
    ubiquitin conjugating enzyme activity UBE2V1; UBE2D2; UBE2J2; UBE2C; UBE2Z; CDC34; UBE2E3; UBE2S; UBE2E2; UBE2Q1
    ubiquitin conjugating enzyme binding RASD2; MARCH6; DCUN1D4; ANKIB1A; RNF144A; RNF19B; DCUN1D2B; RNF40; PPARA; TOLLIP
    ubiquitin protein ligase activity HECTD1; UBE2G1B; RBX1; ITCHA; RNF144AA; PDZD4; NEURL3; ARIH1L; RFFL; MED17
    ubiquitin protein ligase binding RALB; CUL5; MC1R; H2-AB1; TMEM173; CDC34; HSPD1; ARRB2; FZD6; KCNQ3

    ube2v1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ube2v1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ube2v1.


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