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UBE2V1

  • Official Full Name

    ubiquitin-conjugating enzyme E2 variant 1

  • Overview

    Has no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through Lys-63. This type of poly-ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF-kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage.
  • Synonyms

    UBE2V1; ubiquitin-conjugating enzyme E2 variant 1; UBE2V; CROC 1; CROC1; UEV 1; UEV1A; DNA-binding protein; TRAF6-regulated IKK activator 1 beta Uev1A; CIR1; UEV1; UEV-1; CROC-1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Strep
  • Myc
  • DDK
  • N/A
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human UBE2V1-109H Recombinant Human UBE2V1 protein, His-tagged E.coli His 162aa(including fusion tag)
Human UBE2V1-3548H Recombinant Human UBE2V1, GST-tagged E.coli GST 17-109aa
Human UBE2V1-560HCL Recombinant Human UBE2V1 293 Cell Lysate HEK293 N/A
Human UBE2V1-2298H-B Recombinant Human UBE2V1 Protein Pre-coupled Magnetic Beads HEK293
Human UBE2V1-2298H Recombinant Human UBE2V1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human UBE2V1-0519H Recombinant Human UBE2V1 Protein (A2-N147), Tag Free Insect Cell No tag A2-N147
Human UBE2V1-819HFL Recombinant Full Length Human UBE2V1 Protein, C-Flag-tagged Mammalian cells Flag
Human UBE2V1-0520H Recombinant Human UBE2V1 Protein (A2-N147), His/Strep tagged Insect Cell His/Strep A2-N147
Mouse Ube2v1-6800M Recombinant Mouse Ube2v1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rhesus Macaque UBE2V1-5068R Recombinant Rhesus monkey UBE2V1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque UBE2V1-4881R-B Recombinant Rhesus Macaque UBE2V1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque UBE2V1-4881R Recombinant Rhesus Macaque UBE2V1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish UBE2V1-3527Z Recombinant Zebrafish UBE2V1 Mammalian Cell His
Chicken UBE2V1-4508C Recombinant Chicken UBE2V1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

UBE2V1 involved in several pathways and played different roles in them. We selected most pathways UBE2V1 participated on our site, such as Activated TLR4 signalling, Adaptive Immune System, Antigen processing: Ubiquitination &amp, which may be useful for your reference. Also, other proteins which involved in the same pathway with UBE2V1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Activated TLR4 signallingMAPKAPK2B;DUSP3;DUSP4;PELI3;MAP3K8;TANK;CHST13;S100B;TIRAP
Adaptive Immune SystemSIGLEC9;ASB17;GAN;TRIM69;HUWE1;CD300LG;WWP1;RNF25;SH3RF1
Antigen processing: Ubiquitination &ampASB7;ASB4;CMTM2A;ASB10;TRIM69;TRIM39;FBXO27;RNF6;UBE2F
Proteasome degradationRNF182;TRIM39;DZIP3;UBE2E3;ASB6;ASB2;MKRN1;SH3RF1;RNF4
C-type lectin receptors (CLRs)CREBBP;CLEC4A;CLEC4D;AHCYL1;ITPR2;IL1B2;CLEC6A;TAB1;CASP8L1
CLEC7A (Dectin-1) signalingCASP8L1;UBE2V1;IL1B2;TAB1;MALT1;AHCYL1
Class I MHC mediated antigen processing &ampERAP2;RNF34;ASB14;UBE2U;FBXO17;CYBA;ASB6;ARIH2;KLHL21
presentationHUWE1;FBXO27;NPEPPS;B2ML;ASB17;DTX3L;SEC23A;RNF220;BLMH
Cytokine Signaling in Immune systemDUSP7;DPF1;IFIT10;IFIT11;TRIM3;TRIM10;IFI35;IRF6;TRIM38
Downstream TCR signalingHLA-DQB2;UBE2V1;TRAT1

UBE2V1 has several biochemical functions, for example, protein binding, ubiquitin conjugating enzyme activity, ubiquitin conjugating enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UBE2V1 itself. We selected most functions UBE2V1 had, and list some proteins which have the same functions with UBE2V1. You can find most of the proteins on our site.

Function Related Protein
protein bindingSUGT1;BRK1;MYH9;CAMLG;MTTP;MECOM;RAB3IP;SOCS5;HSPA13
ubiquitin conjugating enzyme activityUBE2V1;UBE2D2A;UBE2S;UBE2D2;UBE2Q2;UBE2O;UBE2H;UBE2G2;UBE2D4
ubiquitin conjugating enzyme bindingRNF19A;FOXL2;RNF144B;RNF144A;DCUN1D2A;DCUN1D1;DCUN1D4;RASD2;GRIK2
ubiquitin protein ligase activityCOP1;RNF25;TRAF6;TRIM37;RLIM;FANCL;TMEM189;MYLIP;TRAIP
ubiquitin protein ligase bindingFAF1;MAGEA2B;KCNQ3;BAG6;ATXN3;SMC6;PTPN22;AKTIP;UBE2NB

UBE2V1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UBE2V1 here. Most of them are supplied by our site. Hope this information will be useful for your research of UBE2V1.

UBE2N; XIAP

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