ube4a

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ube4a

Official Full Name ubiquitination factor E4A
Background This gene encodes a member of the U-box ubiquitin ligase family. The encoded protein is involved in multiubiquitin chain assembly and plays a critical role in chromosome condensation and separation through the polyubiquitination of securin. Autoantibodies against the encoded protein may be markers for scleroderma and Crohns disease. A pseudogene of this gene is located on the long arm of chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Synonyms UBE4A; ubiquitination factor E4A; ubiquitination factor E4A (homologous to yeast UFD2) , ubiquitination factor E4A (UFD2 homolog, yeast); ubiquitin conjugation factor E4 A; E4; KIAA0126; UBOX2; UFD2; ubiquitination factor E4A (UFD2 homolog, yeast); MGC13
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Tag :
    • His
    • MYC/DDK
    • Myc
    • DDK
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human UBE4A-3551H Recombinant Human UBE4A, His-tagged E.coli His
    Human UBE4A-480H Recombinant Human UBE4A Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human UBE4A-6028H Recombinant Human UBE4A Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse UBE4A-17741M Recombinant Mouse UBE4A Protein Mammalian Cell His
    Mouse Ube4a-997M Recombinant Mouse Ube4a Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Rat UBE4A-6406R Recombinant Rat UBE4A Protein Mammalian Cell His
    Chicken UBE4A-2599C Recombinant Chicken UBE4A Mammalian Cell His

    ube4a involved in several pathways and played different roles in them. We selected most pathways ube4a participated on our site, such as Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with ube4a were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Ubiquitin mediated proteolysis ANAPC7; UBE2U; UBE2G2; HUWE1; TCEB1B; FBXO4; SMURF1; UBE2D4; PIAS1; UBE2Q1

    ube4a has several biochemical functions, for example, GTPase inhibitor activity, Roundabout binding, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ube4a itself. We selected most functions ube4a had, and list some proteins which have the same functions with ube4a. You can find most of the proteins on our site.

    Function Related Protein
    GTPase inhibitor activity RTKN; UBE4A; TNK2; CDC42SE1; RHOH; PDE6D; IPO5; GPS2; ARL2; GPS1
    Roundabout binding TGFB1I1; SLIT1A; SLIT1; SLIT3; SLIT2; UBE4A; GM4980; SLIT1B
    calcium ion binding EMR4; SGCA; PCDHA9; PCDH21; CD248A; DNASE1L2; PRRG1; CAPN13; CALUA; NECAB1
    chemorepellent activity SEMA5A; SEMA4C; UBE4A; SEMA3H; EPHA7; SEMA3BL; SEMA3G; NRG1; SEMA4E; SEMA5B
    heparan sulfate proteoglycan binding GPC5; AGRN; GPC3; ITGAM; SEMA5A; AZU1; GPC6; GPC1B; GPC1; UBE4A
    heparin binding IMPG2; NRP1A; HSD17B12; PCOLCE; RSPO1; LIPH; ZFP207; NOV; LIPI; CRISPLD2
    identical protein binding MDM2; DESI1; MICALL1; BNIPL; NUFIP1; PRPS2; C1QTNF6; SMG9; ATXN10; ASS1
    laminin-1 binding Shh; NID1; DAG1; LACRT; UBE4A; NTN4; SLIT2
    protein binding NIPSNAP3A; NUP107; LINGO1; CHRAC1; DIP2A; UBE4A; SNRNP25; S100A7; CRELD2; MAGOHB
    protein homodimerization activity CBLN1; SDCBP2; CADM1A; BCL2; BARD1; RAB11FIP4A; DPY30; BCL11A; FGFR1OP; TIGIT
    proteoglycan binding CECR1A; CTSS; UBE4A; CTSK; COL5A1; CTSB; CECR1; THBS1; NID1; SLIT2

    ube4a has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ube4a here. Most of them are supplied by our site. Hope this information will be useful for your research of ube4a.

    MAVS; PTP4A3; UBE2D1; UBE2D3; UBE2D2; UBE2D4; CBX7

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