uchl1
Share
  • Official Full Name
  • ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
  • Background
  • The protein encoded by this gene belongs to the peptidase C12 family. This enzyme is a thiol protease that hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. This gene is specifically expressed in the neurons and in cells of the diffuse neuroendocrine system. Mutations in this gene may be associated with Parkinson disease.[provided by RefSeq, Sep 2009]
  • Synonyms
  • UCHL1; ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase); NDGOA; PARK5; PGP95; PGP9.5; Uch-L1; HEL-117; PGP 9.5; ubiquitin carboxyl-terminal hydrolase isozyme L1; ubiquitin thioesterase L1; epididymis luminal protein 117; neuron cytoplasmic protein 9.5; ubiquitin C-terminal hydrolase;
Cat.#:Uchl1-611MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Uchl1 Protein, His-tagged
+Inquiry
Cat.#:Uchl1-612RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Uchl1 Protein, His-tagged
+Inquiry
Cat.#:UCHL1-1520HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human UCHL1
+Inquiry
Cat.#:UCHL1-1637HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Ubiquitin Carboxyl-Terminal Esterase L1 (ubiquitin thiolesterase), His-tagged
+Inquiry
Cat.#:UCHL1-227HTag:T7/His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human UCHL1 protein, T7/His-tagged
+Inquiry
Cat.#:UCHL1-3091HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human UCHL1, His tagged
+Inquiry
Cat.#:UCHL1-392HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human UCHL1 protein, His-tagged
+Inquiry
Cat.#:UCHL1-49HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human UCHL1, GST-tagged
+Inquiry
Cat.#:UCHL1-7026HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human UCHL1, His-tagged
+Inquiry
Cat.#:UCHL1-17778MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse UCHL1 Protein
+Inquiry
Cat.#:Uchl1-20MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Uchl1, His tagged
+Inquiry
Cat.#:Uchl1-69MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Uchl1, His-tagged
+Inquiry
Cat.#:Uchl1-17RTag:His/S
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Uchl1 protein, His/S-tagged
+Inquiry
Cat.#:Uchl1-1809RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Uchl1, His tagged
+Inquiry
Cat.#:UCHL1-6418RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat UCHL1 Protein
+Inquiry
Cat.#:UCHL1-3608CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken UCHL1
+Inquiry
Cat.#:UCHL1-11523ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish UCHL1
+Inquiry
Cat.#:UCHL1-181HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Ubiquitin Carboxyl-terminal Esterase L1 (Ubiquitin Thiolesterase)
+Inquiry
Cat.#:UCHL1-535HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human UCHL1 293 Cell Lysate
+Inquiry

Involved Pathway

UCHL1 involved in several pathways and played different roles in them. We selected most pathways UCHL1 participated on our site, such as Parkinsons disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with UCHL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Parkinsons disease
PRKACB; NDUFB9; SLC25A4; NDUFA4L2; ATP5D; ATP5E; PARK7; NDUFB3; NDUFS7; UQCRQ

Protein Function

UCHL1 has several biochemical functions, for example, alpha-2A adrenergic receptor binding, cysteine-type endopeptidase activity, ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by UCHL1 itself. We selected most functions UCHL1 had, and list some proteins which have the same functions with UCHL1. You can find most of the proteins on our site.
Function
Related Protein
Function alpha-2A adrenergic receptor binding
Related Protein ADRB1; ADRA2C; ADRBK1; APLP1; UCHL1
Function cysteine-type endopeptidase activity
Related Protein SFRP1; USP47; ATG4C; USP6; ATG4A; CTSC; USP45; USP34; FAM49BA; MALT1A
Function ligase activity
Related Protein AMFR; GLULA; NEURL1B; RNF213; MUL1; NAPRT1; PIAS4; NSMCE2; RFWD3; MARCH5
Function omega peptidase activity
Related Protein APEH; JOSD2; GGH; USP13; ATXN3; USP5; ATXN3L; UCHL5; JOSD1; UCHL1
Function protein binding
Related Protein JAKMIP2; STAG2; CDK9; NUP85; HBB; MAPK6; POLH; IMPA1; KLC1; IGHM
Function ubiquitin binding
Related Protein OTUB1B; FAN1; OTUB1A; SQSTM1; PER2; TOM1L1; IDE; TRIM32; AUP1; UBXN2A
Function ubiquitin protein ligase binding
Related Protein LC3; FZD6; CUL3; UQCRC1; TRAF5; CDC34B; TANK; UBE2NA; PER1; UBE2H
Function ubiquitin-specific protease activity
Related Protein USP7; ATXN3L; COPS5; USP47; USP17L2; MYSM1; VCPIP1; USP22; USP51; USP33

Interacting Protein

UCHL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UCHL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of UCHL1.
COPS5; EGFR; TERF2IP; CDKN1B; NCAM1; EIF1B; KRT4; MCC; VHL; EIF6; KRT17; IKBKE; CCDC14; ATG5; USP21

UCHL1 Related Articles

Zheng, S; Qiao, GL; et al. Heterogeneous expression and biological function of ubiquitin carboxy-terminal hydrolase-L1 in osteosarcoma. CANCER LETTERS 359:36-46(2015).
Brackeva, B; De Punt, V; et al. Potential of UCHL1 as biomarker for destruction of pancreatic beta cells. JOURNAL OF PROTEOMICS 117:156-167(2015).