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UCHL1

  • Official Full Name

    ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)

  • Overview

    The protein encoded by this gene belongs to the peptidase C12 family. This enzyme is a thiol protease that hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. This gene is specifically expressed in the neurons and in cells of the diffuse neuroendocrine system. Mutations in this gene may be associated with Parkinson disease.[provided by RefSeq, Sep 2009]
  • Synonyms

    UCHL1; ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase); NDGOA; PARK5; PGP95; PGP9.5; Uch-L1; HEL-117; PGP 9.5; ubiquitin carboxyl-terminal hydrolase isozyme L1; ubiquitin thioesterase L1; epididymis luminal protein 117; neuron cytoplasmic protein 9.5; ubiquitin C-terminal hydrolase;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Antibody
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Human
  • Mammalian Cell
  • Mammalian cells
  • Rabbit
  • C
  • His
  • Flag
  • GST
  • His (Fc)
  • Avi
  • His|S
  • Myc
  • DDK
  • N/A
  • N
  • No tag
  • T7|His
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human UCHL1-1520H Recombinant Human UCHL1 Human N/A
Human UCHL1-1637H Recombinant Human Ubiquitin Carboxyl-Terminal Esterase L1 (ubiquitin thiolesterase), His-tagged E.coli His
Human UCHL1-3091H Recombinant Human UCHL1 protein, His-tagged E.coli His Gln 2 - Ala 223
Human UCHL1-49H Recombinant Human UCHL1, GST-tagged E.coli GST
Human UCHL1-227H Recombinant Human UCHL1 protein, T7/His-tagged E.coli T7/His
Human UCHL1-392H Recombinant Human UCHL1 protein, His-tagged E.coli His
Human UCHL1-535HCL Recombinant Human UCHL1 293 Cell Lysate HEK293 N/A
Human CAB11621RH Rabbit Monoclonal Antibody to Human Ubiquitin Carboxyl-Terminal Esterase L1 Rabbit N/A
Human UCHL1-1340S Recombinant Human UCHL1 Protein (Q2-A223), Tag Free E.coli No tag Q2-A223
Human UCHL1-1339S Recombinant Human UCHL1 Protein (Q2-A223), His tagged E.coli His Q2-A223
Human UCHL1-35H Recombinant Human UCHL1 Protein, His-tagged E.coli His 2–224 aa
Human UCHL1-01HFL Recombinant Full Length Human UCHL1 Protein, C-Flag-tagged Mammalian cells Flag
Human UCHL18169H Recombinant Human UCHL1 (1-223) Protein
Human UCHL1-2302H Recombinant Human UCHL1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human UCHL1-8938H Active Recombinant Human UCHL1 protein, His-tagged E.coli His 2-223
Human UCHL1-2618H Recombinant Human UCHL1 protein(71-150 aa), C-His-tagged E.coli C-His 71-150 aa
Human UCHL1-2302H-B Recombinant Human UCHL1 Protein Pre-coupled Magnetic Beads HEK293
Human UCHL1-2619H Recombinant Human UCHL1 protein(61-150 aa), C-His-tagged E.coli C-His 61-150 aa
Human UCHL1-20H Recombinant Human UCHL1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Human UCHL1-2620H Recombinant Human UCHL1 protein(111-210 aa), C-His-tagged E.coli C-His 111-210 aa
Human UCHL1-2878H Recombinant Human UCHL1 protein(1-220 aa), C-His-tagged E.coli C-His 1-220 aa
Human UCHL1-6106H Recombinant Human UCHL1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Mouse Uchl1-69M Recombinant Mouse Uchl1, His-tagged E.coli His
Mouse Uchl1-20M Active Recombinant Mouse Uchl1 protein(Gln2-Ala223), His-tagged E.coli N-His Gln2-Ala223
Mouse UCHL1-17778M Recombinant Mouse UCHL1 Protein Mammalian Cell His
Mouse Uchl1-6819M Recombinant Mouse Uchl1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse UCHL1-9868M-B Recombinant Mouse UCHL1 Protein Pre-coupled Magnetic Beads HEK293
Mouse UCHL1-9868M Recombinant Mouse UCHL1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Uchl1-7361M Recombinant Mouse Uchl1 Protein, His-tagged E.coli His 1-223
Mouse Uchl1-611M Active Recombinant Mouse Uchl1 Protein, His-tagged E.coli His Gln 2-Ala 223
Rat Uchl1-1809R Active Recombinant Rat Uchl1 protein(Glu2-Ala223), His-tagged E.coli N-His Glu2-Ala223
Rat UCHL1-6418R Recombinant Rat UCHL1 Protein Mammalian Cell His
Rat Uchl1-17R Recombinant Rat Uchl1 protein, His/S-tagged E.coli His/S Val113~Glu211
Rat Uchl1-612R Active Recombinant Rat Uchl1 Protein, His-tagged E.coli His Gln2~Ala223
Rat UCHL1-6074R-B Recombinant Rat UCHL1 Protein Pre-coupled Magnetic Beads HEK293
Rat UCHL1-6074R Recombinant Rat UCHL1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish UCHL1-11523Z Recombinant Zebrafish UCHL1 Mammalian Cell His
Chicken UCHL1-3608C Recombinant Chicken UCHL1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

UCHL1 involved in several pathways and played different roles in them. We selected most pathways UCHL1 participated on our site, such as Parkinsons disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with UCHL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Parkinsons diseaseNDUFV2;ATP5A1;COX7A2L;UBB;SDHB;COX8C;PARK2;NDUFS7;HTRA2

UCHL1 has several biochemical functions, for example, alpha-2A adrenergic receptor binding, cysteine-type endopeptidase activity, ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by UCHL1 itself. We selected most functions UCHL1 had, and list some proteins which have the same functions with UCHL1. You can find most of the proteins on our site.

Function Related Protein
alpha-2A adrenergic receptor bindingUCHL1;APLP1;ADRA2C;ADRBK1;ADRB1
cysteine-type endopeptidase activityCTSM;CASP6L1;LGMN;USP22;USP18;USP34;USP17L5;CASP3B;USP19
ligase activityNAPRT;RNF20;HERC4;MUL1A;SMURF1;TNFAIP3;MIB1;SIAH2;TRIM5
omega peptidase activityUCHL1;USP13;USP5;UCHL5;ATXN3L;APEH;GGH;JOSD2;JOSD1
protein bindingTCEA2;ZBTB48;PFKFB2;CHID1;HMGA1;MAPK1;RIBC1;PIN4;RHO
ubiquitin bindingSMAD3;NSFL1C;BCL10;OTUB1;NUP62;DYRK2;IDE;KCNS1;SQSTM1
ubiquitin protein ligase bindingCDKN1A;MDM2;GPI1;IKBKE;SPG20;POLR2A;NFKBIA;RNF20;TMBIM6
ubiquitin-specific protease activityUCHL3;FAM105B;USP27X;USP17L5;OTUD3;ZRANB1B;BAP1;USP28;USP43

UCHL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UCHL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of UCHL1.

COPS5; EGFR; TERF2IP; CDKN1B; NCAM1; EIF1B; KRT4; MCC; VHL; EIF6; KRT17; IKBKE; CCDC14; ATG5; USP21

Research Area

Related articles

Zheng, S; Qiao, GL; et al. Heterogeneous expression and biological function of ubiquitin carboxy-terminal hydrolase-L1 in osteosarcoma. CANCER LETTERS 359:36-46(2015).
Brackeva, B; De Punt, V; et al. Potential of UCHL1 as biomarker for destruction of pancreatic beta cells. JOURNAL OF PROTEOMICS 117:156-167(2015).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
Can UCHL1 be used in the early diagnosis of neurodegenerative diseases? 10/19/2021

Early research suggests that changes in UCHL1 levels may be detected in the early stages of some neurodegenerative diseases, but more studies are needed for validation.

Is UCHL1 exclusively associated with neurological functions? 11/22/2019

While UCHL1 is primarily associated with neurological functions, it also has roles in non-neuronal tissues, including certain types of cancer cells.

What are the challenges in using UCHL1 as a diagnostic marker? 09/25/2019

Challenges include the need for standardized assays, variations in UCHL1 levels among individuals, and the influence of other factors on its expression.

Can UCHL1 levels serve as a biomarker for neurodegenerative diseases? 11/22/2017

Yes, elevated or decreased levels of UCHL1 in cerebrospinal fluid or blood may serve as potential biomarkers for certain neurological disorders.

What other conditions or diseases are associated with UCHL1 dysfunction? 07/05/2016

UCHL1 dysfunction has been implicated in conditions such as certain cancers and ischemic stroke.

Customer Reviews (3)

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Reviews
01/22/2021

    Whether it is regarding experimental design, optimization of protocols, or troubleshooting issues, their expertise and prompt customer service help researchers overcome challenges efficiently.

    11/10/2018

      They provide comprehensive technical assistance and guidance throughout the entire research process.

      01/24/2018

        Heir responsiveness to inquiries and willingness to address concerns contribute to a smooth and productive research experience.

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