Recombinant Human UCHL1 (1-223) Protein

• Cat.No.: UCHL18169H

Specification

• Description: UCHL1 (human) was expressed and purified from E.coli. The protein was expressed as a N-terminal GST-fusion protein and a C-terminal Ubiquitin-fusion and purified by a three-step chromatographic procedure comprising affinity and size exclusion chromatography steps including tag cleavage.
• Species: Human
• Molecular Mass: 33.84 kDa
• Purity: > 95%
• Storage: frozen; -80
• Storage Buffer: 50 mM TRIS, pH 7.4;150 mM NaCl;0.5 mM TCEP

Gene Information

• Gene Name: UCHL1 (1-223)
• Official Symbol: UCHL1
• Synonyms: Ubiquitin Specific Peptidase 14; Ubiquitin Specific Peptidase 14 (TRNA-Guanine Transglycosylase); Ubiquitin Specific Protease 14 (TRNA-Guanine Transglycosylase); Deubiquitinating Enzyme 14; Ubiquitin Thioesterase 14; TGT; TRNA-Guanine Transglycosylase; 60-KD Subunit
• Gene ID: 7345
• UniProt ID: P09936

Reviews

01/22/2021

Whether it is regarding experimental design, optimization of protocols, or troubleshooting issues, their expertise and prompt customer service help researchers overcome challenges efficiently.

11/10/2018

They provide comprehensive technical assistance and guidance throughout the entire research process.

01/24/2018

Heir responsiveness to inquiries and willingness to address concerns contribute to a smooth and productive research experience.

Q&As

Can UCHL1 be used in the early diagnosis of neurodegenerative diseases?

Early research suggests that changes in UCHL1 levels may be detected in the early stages of some neurodegenerative diseases, but more studies are needed for validation.

Is UCHL1 exclusively associated with neurological functions?

While UCHL1 is primarily associated with neurological functions, it also has roles in non-neuronal tissues, including certain types of cancer cells.

What are the challenges in using UCHL1 as a diagnostic marker?

Challenges include the need for standardized assays, variations in UCHL1 levels among individuals, and the influence of other factors on its expression.

Can UCHL1 levels serve as a biomarker for neurodegenerative diseases?

Yes, elevated or decreased levels of UCHL1 in cerebrospinal fluid or blood may serve as potential biomarkers for certain neurological disorders.

What other conditions or diseases are associated with UCHL1 dysfunction?

UCHL1 dysfunction has been implicated in conditions such as certain cancers and ischemic stroke.