UGT1A3

  • Official Full Name

    UDP glucuronosyltransferase 1 family, polypeptide A3

  • Overview

    This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5 exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. Substrates of this enzyme include estrone, 2-hydroxyestrone, and metabolites of benzo alpha-pyrene.
  • Synonyms

    UGT1A3; UDP glucuronosyltransferase 1 family, polypeptide A3; UDP glycosyltransferase 1 family, polypeptide A3; UDP-glucuronosyltransferase 1-3; UGT1C; EC 2.4.1.17; GNT 1; GNT1; UDP glucuronosyltransferase 1 3; UDP glucuronosyltransferase 1 family polypeptide A3; UDP glucuronosyltransferase 1A3; UDP glucuronosyltransferase; UDP glycosyltransferase 1 family polypeptide A3; UDPGT; UGT 1; UGT 1C; UGT1; UGT1 03; UGT1*3; UGT1.3; OTTHUMP00000065193; UDP-glucuronosyltransferase 1-C; UDP-glucuronosyltransferase 1A3; UGT-1C; UGT1-03; UDPGT 1-3;

  • Recombinant Proteins
  • Homo sapiens (Human)
  • Human
  • Rattus norvegicus (Rat)
  • E.coli expression system
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Insect cells
  • Wheat Germ
  • His
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human UGT1A3-207H Recombinant Human UGT1A3 Wheat Germ N/A
Human UGT1A3-512H Recombinant Human UGT1A3 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human UGT1A3-98H Active Recombinant Human UGT1A3 Protein Insect cells
Human UGT1A3-3375H Recombinant Human UGT1A3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human UGT1A3-539HF Recombinant Full Length Human UGT1A3 Protein In Vitro Cell Free System 534 amino acids
Homo sapiens (Human) RFL8549HF Recombinant Full Length Human Udp-Glucuronosyltransferase 1-3(Ugt1A3) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (29-534)
Rattus norvegicus (Rat) RFL8576RF Recombinant Full Length Rat Udp-Glucuronosyltransferase 1-3(Ugt1) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (26-531)
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

UGT1A3 involved in several pathways and played different roles in them. We selected most pathways UGT1A3 participated on our site, such as Pentose and glucuronate interconversions, Ascorbate and aldarate metabolism, Steroid hormone biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with UGT1A3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Pentose and glucuronate interconversionsAKR1B10;UGT1A6A;AKR1B1;GUSB;UGT1A1;KL;ALDH3A2;DCXR;ALDH1B1
Ascorbate and aldarate metabolismALDH9A1B;UGDH;ALDH9A1;UGT1A4;UGT1A2;ALDH2;UGT1A7;UGT5G1;GKUP
Steroid hormone biosynthesisSULT2ST3;HSD17B7;UGT1A9;CYP3A7-CYP3AP1;STS;CYP7A1A;UGT1AB;CYP19A1B;CYP2C39
Starch and sucrose metabolismAMY2A3;PYGMA;UGT1A6B;G6PC3;UGT2A3;AMY2A;UGT1A6A;UGT1A1;AMY2B
Retinol metabolismRDH5;UGT1A6B;UGT1AB;CYP2C45;CYP2C39;AOX3L1;UGT2A1;CYP3A41A;AOX1
Porphyrin and chlorophyll metabolismHMOX2A;UGT1A4;PPOX;UGT1A6A;EPRS;CP;HMOX2;UGT1A6B;HCCSB
Metabolism of xenobiotics by cytochrome PUGT2A1;ADH1;GSTA2;GSTT2;CBR1L;GSTT2B;GSTA3;UGT1A3;UGT1A6B
Drug metabolism - cytochrome PGSTM6;MGST2;MAOA;GSTA3;GSTM;GSTAL;MAOB;UGT1A1;AOX3
Drug metabolism - other enzymesUGT1A2;TPMT.1;IMPDH1B;UGT1A7;UGT1AB;UCKL1;UGT5G1;UGT1A6;IMPDH1
Metabolic pathwaysAKR1B10;PGK1;UCK1;CYP2B19;GALNTL6;NME3;NDUFS2;NDUFB11;NADKD1
Chemical carcinogenesisCYP2E1;CYP2C55;ALDH1A3;CBR1;ADH2-1;NAT2;UGT2A2;CYP2C70;GSTP1

UGT1A3 has several biochemical functions, for example, enzyme binding, glucuronosyltransferase activity, NOT glucuronosyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by UGT1A3 itself. We selected most functions UGT1A3 had, and list some proteins which have the same functions with UGT1A3. You can find most of the proteins on our site.

Function Related Protein
enzyme bindingHDAC10;SCN5A;PLSCR4;SIRT3;GBP1;APP;TOP2B;TSPAN33;ABCD1
glucuronosyltransferase activityUGT2B3;UGT5C2;UGT5A4;UGT2A6;UGT3A2;UGT1A4;GYLTL1B;UGT5G1;UGT1AB
NOT glucuronosyltransferase activityUGT1A6;UGT1A9;UGT1A3;UGT1A4;UGT1A1;UGT1A7
protein heterodimerization activityAHR;ITGB1;CHRNA3;CHRNA5;ABCG8;ZBTB1;HIST1H3D;CEBPB;KCNH1
protein homodimerization activityCREB3L3;ABCB9;GREM2;CAV2;TRIM8;Fzd4;PML;HSP90AA1;VEGFB
retinoic acid bindingLRAT;LCN12;PTGDSB;SERPINA5;CYP26A1;CRABP2;UGT1A2;CRABP1A;CRABP1B

UGT1A3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UGT1A3 here. Most of them are supplied by our site. Hope this information will be useful for your research of UGT1A3.

Research Area

Related articles

Lee, SJ; Park, JB; et al. In vitro selective inhibition of human UDP-glucuronosyltransferase (UGT) 1A4 by finasteride, and prediction of in vivo drug-drug interactions. TOXICOLOGY LETTERS 232:458-465(2015).
Tian, XG; Liang, SC; et al. Regioselective Glucuronidation of Andrographolide and Its Major Derivatives: Metabolite Identification, Isozyme Contribution, and Species Differences. AAPS JOURNAL 17:156-166(2015).
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