UGT1A3 Protein


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Official Full Name UDP glucuronosyltransferase 1 family, polypeptide A3
Background This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5 exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. Substrates of this enzyme include estrone, 2-hydroxyestrone, and metabolites of benzo alpha-pyrene.
Synonyms UGT1A3; UDP glucuronosyltransferase 1 family, polypeptide A3; UDP glycosyltransferase 1 family, polypeptide A3; UDP-glucuronosyltransferase 1-3; UGT1C; EC; GNT 1; GNT1; UDP glucuronosyltransferase 1 3; UDP glucuronosyltransferase 1 family polypeptide A3; UDP glucuronosyltransferase 1A3; UDP glucuronosyltransferase; UDP glycosyltransferase 1 family polypeptide A3; UDPGT; UGT 1; UGT 1C; UGT1; UGT1 03; UGT1*3; UGT1.3; OTTHUMP00000065193; UDP-glucuronosyltransferase 1-C; UDP-glucuronosyltransferase 1A3; UGT-1C; UGT1-03; UDPGT 1-3;
    • Species :
    • Homo sapiens (Human)
    • Human
    • Rattus norvegicus (Rat)
    • Source :
    • E.coli expression system
    • HEK293
    • HEK293T
    • In Vitro Cell Free System
    • Insect cells
    • Wheat Germ
    • Tag :
    • His
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human UGT1A3-207H Recombinant Human UGT1A3 Wheat Germ N/A Inquiry
    Homo sapiens (Human) RFL8549HF Recombinant Full Length Human Udp-Glucuronosyltransferase 1-3(Ugt1A3) Protein, His-Tagged E.coli expression system His Inquiry
    Rattus norvegicus (Rat) RFL8576RF Recombinant Full Length Rat Udp-Glucuronosyltransferase 1-3(Ugt1) Protein, His-Tagged E.coli expression system His Inquiry
    Human UGT1A3-539HF Recombinant Full Length Human UGT1A3 Protein In Vitro Cell Free System Inquiry
    Human UGT1A3-3375H Recombinant Human UGT1A3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK Inquiry
    Human UGT1A3-512H Recombinant Human UGT1A3 Protein, MYC/DDK-tagged HEK293 Myc/DDK Inquiry
    Human UGT1A3-98H Recombinant Human UGT1A3 Protein Insect cells Inquiry

    UGT1A3 involved in several pathways and played different roles in them. We selected most pathways UGT1A3 participated on our site, such as Pentose and glucuronate interconversions, Ascorbate and aldarate metabolism, Steroid hormone biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with UGT1A3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Pentose and glucuronate interconversions AKR1A1A; UGP2A; ALDH2.2; UGT1A4; UGT2B15; UGT2A3; RPE; DHDH; Akr1b3; UGP2
    Ascorbate and aldarate metabolism UGT1A9; ALDH9A1; ALDH2; UGT2A2; UGT1A6A; UGT1A6; GULO; UGT5G1; UGT2B7; UGT1A7
    Steroid hormone biosynthesis UGT1A7C; CYP19A1B; UGT2A1; HSD3B5; UGT1A2; CYP2C37; CYP3A41A; UGT2A3; UGT5G1; UGT1A1
    Starch and sucrose metabolism UGT1A2; G6PCA.2; GPI; PGM1; PYGL; UGT2A2; G6PC3; G6PC; UGT1A9; AGLA
    Retinol metabolism DGAT1A; CYP2C37; ADH2-1; RDH8A; UGT2A2; AOX3; CYP2C50; CYP4A10; UGT1A2; ADH2-2
    Porphyrin and chlorophyll metabolism COX10; EARS2; ALAS1; HMOX1A; HMOX2; BLVRA; UGT1A6B; FECH; UGT1A3; UGT5G1
    Metabolism of xenobiotics by cytochrome P MGST2; UGT5G1; GSTP2; UGT1A6B; GSTA4; GSTT2; GSTO1; CYP1A; GSTM4; GSTM1
    Drug metabolism - cytochrome P GSTA2; GSTM7; GSTP1; FMO2; GSTA; MAOA; UGT1A9; UGT1A3; UGT1AB; MAOB
    Drug metabolism - other enzymes CES1D; NAT2; PNAT3; Nat3; TPMT; CDA; IMPDH2; UPP2; UGT1A6B; XDH
    Metabolic pathways ST3GAL1; C1GALT1C1; NANP; ST3GAL2; GUK1; ST6GALNAC3; NME1-NME2; HMBSB; PFKM; TYR
    Chemical carcinogenesis ADH7; GSTK1; MGST3; UGT1A6B; MGST2; ADH1A; CYP2E1; UGT1A1; CYP2C18; HSD11B1

    UGT1A3 has several biochemical functions, for example, enzyme binding, glucuronosyltransferase activity, NOT glucuronosyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by UGT1A3 itself. We selected most functions UGT1A3 had, and list some proteins which have the same functions with UGT1A3. You can find most of the proteins on our site.

    Function Related Protein
    enzyme binding PARK7; LYN; BACE1; LAMP2; APOA5; TOP2A; DAOA; NOS1; TSPAN14; LUC7L2
    glucuronosyltransferase activity UGT8; UGT5A3; UGT2A1; UGT1A7; UGT5C1; UGT8A; EXT1; UGT5C3; UGT1B7; UGT1A3
    NOT glucuronosyltransferase activity UGT1A6; UGT1A7; UGT1A9; UGT1A1; UGT1A3; UGT1A4
    protein heterodimerization activity NEUROD1; NEFH; WHRN; HIST1H2BD; HIST1H4K; ATP4A; H3F3C; BCL2A1; SMAD3; PANX2
    protein homodimerization activity TPD52L1; PDE2A; VPS25; SMAD2; RAB11FIP4B; UPK1A; VEGFB; FGFR1; TBX18; QPRT
    retinoic acid binding UGT1A9; CRABP2; RARA; CRABP2A; CRABP2B; CRABP1B; CRABP1; LRAT; SERPINA5; UGT1A2

    UGT1A3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UGT1A3 here. Most of them are supplied by our site. Hope this information will be useful for your research of UGT1A3.

    Lee, SJ; Park, JB; et al. In vitro selective inhibition of human UDP-glucuronosyltransferase (UGT) 1A4 by finasteride, and prediction of in vivo drug-drug interactions. TOXICOLOGY LETTERS 232:458-465(2015).
    Tian, XG; Liang, SC; et al. Regioselective Glucuronidation of Andrographolide and Its Major Derivatives: Metabolite Identification, Isozyme Contribution, and Species Differences. AAPS JOURNAL 17:156-166(2015).

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