UGT1A3

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UGT1A3

Official Full Name UDP glucuronosyltransferase 1 family, polypeptide A3
Background This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5 exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. Substrates of this enzyme include estrone, 2-hydroxyestrone, and metabolites of benzo alpha-pyrene.
Synonyms UGT1A3; UDP glucuronosyltransferase 1 family, polypeptide A3; UDP glycosyltransferase 1 family, polypeptide A3; UDP-glucuronosyltransferase 1-3; UGT1C; EC 2.4.1.17; GNT 1; GNT1; UDP glucuronosyltransferase 1 3; UDP glucuronosyltransferase 1 family polypeptide A3; UDP glucuronosyltransferase 1A3; UDP glucuronosyltransferase; UDP glycosyltransferase 1 family polypeptide A3; UDPGT; UGT 1; UGT 1C; UGT1; UGT1 03; UGT1*3; UGT1.3; OTTHUMP00000065193; UDP-glucuronosyltransferase 1-C; UDP-glucuronosyltransferase 1A3; UGT-1C; UGT1-03; UDPGT 1-3
    • Species :
    • Human
    • Source :
    • HEK293
    • HEK293T
    • Insect cells
    • Wheat Germ
    • Tag :
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human UGT1A3-207H Recombinant Human UGT1A3 Wheat Germ N/A
    Human UGT1A3-3375H Recombinant Human UGT1A3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human UGT1A3-512H Recombinant Human UGT1A3 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human UGT1A3-98H Recombinant Human UGT1A3 Protein Insect cells

    UGT1A3 involved in several pathways and played different roles in them. We selected most pathways UGT1A3 participated on our site, such as Pentose and glucuronate interconversions, Ascorbate and aldarate metabolism, Steroid hormone biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with UGT1A3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Pentose and glucuronate interconversions UGT2B7; UGT1A4; ALDH3A2; KL; DHDHL; UGT1A2; XYLB; UGDH; SORD; UGT2A1
    Ascorbate and aldarate metabolism ALDH3A2; UGT1A6A; ALDH2; UGT2B15; UGT2B7; UGT5G1; UGT1A4; ALDH2.2; UGT2A1; ALDH1B1
    Steroid hormone biosynthesis CYP3A41A; CYP2C38; HSD3B1; UGT1AB; CYP2C50; HSD17B2; CYP2D10; HSD17B6; H2-KE6; HSD3B2
    Starch and sucrose metabolism GBA3; AGL; PYGM; UGT1A7C; AMY2A5; UGDH; UGT1A9; GUSB; UXS1; UGT5G1
    Retinol metabolism RDH8A; RPE65; CYP2A4; AOX4; UGT1A2; CYP2C37; RDH8B; BCMO1; CYP2C70; UGT1AB
    Porphyrin and chlorophyll metabolism HCCS; P22; HEPH; HCCSB; UGT1A6B; ALAD; HMOX2; UGT1A2; UGT1A4; UGT2A2
    Metabolism of xenobiotics by cytochrome P UGT1A1; ALDH3A1; UGT2A1; EPHX1; GSTM6; AKR7A5; GSTA1; GSTP1; GSTT2B; ALDH3B1
    Drug metabolism - cytochrome P GSTM4; UGT1A1; GSTP2; GSTAL; UGT2B7; AOX2P; GSTA; UGT1A6; UGT1A6B; GSTM6
    Drug metabolism - other enzymes UGT2A3; NAT1; NAT2; UGT2B7; NAT; IMPDH1B; UGT1A1; UGT1A4; CES1; TYMP
    Metabolic pathways PTDSS2; OAT; NDST4; ALOX12E; PTGDS; BCAT1; PLCB2; TREH; PLCD3A; CYP4F18
    Chemical carcinogenesis ADH1; GSTK1; CYP2C39; CYP2C9; GSTP1; ADH1A; CBR1; CYP2C70; CYP2C54; CYP3A4

    UGT1A3 has several biochemical functions, for example, enzyme binding, glucuronosyltransferase activity, NOT glucuronosyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by UGT1A3 itself. We selected most functions UGT1A3 had, and list some proteins which have the same functions with UGT1A3. You can find most of the proteins on our site.

    Function Related Protein
    enzyme binding ZFHX3; CCDC99; HIST1H2AL; UGT1A2; RFC5; EHHADH; NCOA1; CD4; MAT2B; GSTM2
    glucuronosyltransferase activity UGT2A1; UGT1A4; UGT8; UGT2B6; UGT5B2; UGT1A6B; UGT1A9; UGT1A6; UGT1B3; UGT2B15
    NOT glucuronosyltransferase activity UGT1A3; UGT1A7; UGT1A4; UGT1A1; UGT1A9; UGT1A6
    protein heterodimerization activity SNX2; CABYR; ARNT2; SUPT5H; CD3E; NEUROD1; SNX6; H2AFJ; JDP2; TAF9
    protein homodimerization activity PRKG2; ENPP1; FLNA; ERBB3; PDK2; PAH; KLHL7; BMP2B; HSP90AA1; GOLGA5
    retinoic acid binding SERPINA5; CYP26B1; RARA; CRABP1; UGT1A1; UGT1A3; NR2F2; UGT1A7; CRABP2; UGT1A2

    UGT1A3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UGT1A3 here. Most of them are supplied by our site. Hope this information will be useful for your research of UGT1A3.

    Lee, SJ; Park, JB; et al. In vitro selective inhibition of human UDP-glucuronosyltransferase (UGT) 1A4 by finasteride, and prediction of in vivo drug-drug interactions. TOXICOLOGY LETTERS 232:458-465(2015).
    Tian, XG; Liang, SC; et al. Regioselective Glucuronidation of Andrographolide and Its Major Derivatives: Metabolite Identification, Isozyme Contribution, and Species Differences. AAPS JOURNAL 17:156-166(2015).

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