UGT1A3

  • Official Full Name

    UDP glucuronosyltransferase 1 family, polypeptide A3
  • Overview

    This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5 exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. Substrates of this enzyme include estrone, 2-hydroxyestrone, and metabolites of benzo alpha-pyrene.
  • Synonyms

    UGT1A3;UDP glucuronosyltransferase 1 family, polypeptide A3;UDP glycosyltransferase 1 family, polypeptide A3;UDP-glucuronosyltransferase 1-3;UGT1C;EC 2.4.1.17;GNT 1;GNT1;UDP glucuronosyltransferase 1 3;UDP glucuronosyltransferase 1 family polypeptide A3;UDP glucuronosyltransferase 1A3;UDP glucuronosyltransferase;UDP glycosyltransferase 1 family polypeptide A3;UDPGT;UGT 1;UGT 1C;UGT1;UGT1 03;UGT1*3;UGT1.3;OTTHUMP00000065193;UDP-glucuronosyltransferase 1-C;UDP-glucuronosyltransferase 1A3;UGT-1C;UGT1-03;UDPGT 1-3

Recombinant Proteins

  • Human
  • Rat
  • Wheat Germ
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Insect cells
  • Non
  • His
  • DDK
  • Myc
Cat.# Product name Source (Host) Species Tag Protein Length Price
UGT1A3-207H Recombinant Human UGT1A3 Wheat Germ Human Non
RFL8549HF Recombinant Full Length Human Udp-Glucuronosyltransferase 1-3(Ugt1A3) Protein, His-Tagged E.coli Human His Full L. Full Length of Mature Protein (29-534)
RFL8576RF Recombinant Full Length Rat Udp-Glucuronosyltransferase 1-3(Ugt1) Protein, His-Tagged E.coli Rat His Full L. Full Length of Mature Protein (26-531)
UGT1A3-3375H Recombinant Human UGT1A3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human DDK&Myc
UGT1A3-512H Recombinant Human UGT1A3 Protein, MYC/DDK-tagged HEK293 Human DDK&Myc
UGT1A3-539HF Recombinant Full Length Human UGT1A3 Protein In Vitro Cell Free System Human Full L. 534 amino acids
UGT1A3-98H Active Recombinant Human UGT1A3 Protein Insect cells Human

    Involved Pathway

    UGT1A3 involved in several pathways and played different roles in them. We selected most pathways UGT1A3 participated on our site, such as Pentose and glucuronate interconversions,Ascorbate and aldarate metabolism,Steroid hormone biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with UGT1A3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Steroid hormone biosynthesis SRD5A3,CYP2C55,AKR1C2,CYP21A1,CYP3A41B,H2-KE6,HSD17B12,STS,CYP7A1A,UGT1AB
    Ascorbate and aldarate metabolism MIOX,ALDH2.1,UGT2A1,UGT1A2,ALDH2,UGT1A6B,ALDH3A2A,GKUP,UGT5G1,ALDH9A1
    Drug metabolism - cytochrome P GSTT1B,GSTO1,UGT2A1,GSTM7,FMO6P,UGT2A2,GSTM6,GSTA4,GSTM3,UGT5G1
    Metabolic pathways GNSA,HYAL1,PGD,COX6B1,CKMT1B,MTAP,COX7B,PNP6,DHRS13L1,CKMT1A
    Porphyrin and chlorophyll metabolism UGT2A1,UGT1A6B,HCCS,UROS,MMAB,UGT1A4,HMOX1,EPRS,UGT2B15,UGT2A2
    Chemical carcinogenesis CYP3A7,UGT1A9,ALDH1A3,CYP2E1,CYP1B1,CYP2A13,ADH2-1,CYP2C38,SULT1A2,GSTP2
    Pentose and glucuronate interconversions UGT1A6A,UGP2B,UGT1A7C,UGT2B7,AKR1B8,UGT2B15,AKR1B1L,UGT1A2,DHDH,UGT5G1
    Drug metabolism - other enzymes UPP2,UPP1,UGT1A2,DPYDB,Nat3,UCK2A,UGT1A7C,UGT1A1,XDH,PNAT3
    Metabolism of xenobiotics by cytochrome P UGT5G1,DHDH,AKR7A3,UGT1A4,ADH1,UGT1A6,GSTT2B,ALDH3B1,CBR3,UGT2A1

    Protein Function

    UGT1A3 has several biochemical functions, for example, enzyme binding,glucuronosyltransferase activity,NOT glucuronosyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by UGT1A3 itself. We selected most functions UGT1A3 had, and list some proteins which have the same functions with UGT1A3. You can find most of the proteins on our site.

    Function Related Protein
    enzyme binding CAV1,EGFR,GSTM4,NLRP1,Alb,ZNHIT6,TRAF2,CYP1A1,HIST1H2AM,PARP1
    retinoic acid binding PTGDSB,UGT1A1,LRAT,RARA,CYP26A1,CRABP2,CRABP1A,CRABP1,CRABP1B,LCN12
    NOT glucuronosyltransferase activity UGT1A7,UGT1A4,UGT1A1,UGT1A9,UGT1A6
    glucuronosyltransferase activity UGT1B2,UGT1A6A,UGT5D1,UGT1B1,UGT2A1,UGT1A4,UGT5A5,UGT5G2,UGT2B15,B3GNT1
    protein homodimerization activity RAB11FIP4A,ALX1,FGFR1OP,PDK2,PRPS2,Il6ra,CADM3,SUMF1,ERN1,SYNE1
    protein heterodimerization activity TYR,PRPH,TENM2,H2AFB1,MAFG,DRD2,SPTA1,UGT1A7,INHBA,SOX32

    Interacting Protein

    UGT1A3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UGT1A3 here. Most of them are supplied by our site. Hope this information will be useful for your research of UGT1A3.

    Resources

    References

    • Lee, SJ; Park, JB; et al. In vitro selective inhibition of human UDP-glucuronosyltransferase (UGT) 1A4 by finasteride, and prediction of in vivo drug-drug interactions. TOXICOLOGY LETTERS 232:458-465(2015).
    • Tian, XG; Liang, SC; et al. Regioselective Glucuronidation of Andrographolide and Its Major Derivatives: Metabolite Identification, Isozyme Contribution, and Species Differences. AAPS JOURNAL 17:156-166(2015).

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