UGT1A3
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Official Full Name
UDP glucuronosyltransferase 1 family, polypeptide A3 -
Overview
This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5 exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. Substrates of this enzyme include estrone, 2-hydroxyestrone, and metabolites of benzo alpha-pyrene. -
Synonyms
UGT1A3;UDP glucuronosyltransferase 1 family, polypeptide A3;UDP glycosyltransferase 1 family, polypeptide A3;UDP-glucuronosyltransferase 1-3;UGT1C;EC 2.4.1.17;GNT 1;GNT1;UDP glucuronosyltransferase 1 3;UDP glucuronosyltransferase 1 family polypeptide A3;UDP glucuronosyltransferase 1A3;UDP glucuronosyltransferase;UDP glycosyltransferase 1 family polypeptide A3;UDPGT;UGT 1;UGT 1C;UGT1;UGT1 03;UGT1*3;UGT1.3;OTTHUMP00000065193;UDP-glucuronosyltransferase 1-C;UDP-glucuronosyltransferase 1A3;UGT-1C;UGT1-03;UDPGT 1-3
Recombinant Proteins
- Human
- Rat
- Wheat Germ
- E.coli
- HEK293
- In Vitro Cell Free System
- Insect cells
- Non
- His
- DDK
- Myc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| UGT1A3-207H | Recombinant Human UGT1A3 | Wheat Germ | Human | Non |
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| RFL8549HF | Recombinant Full Length Human Udp-Glucuronosyltransferase 1-3(Ugt1A3) Protein, His-Tagged | E.coli | Human | His | Full L. Full Length of Mature Protein (29-534) |
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| RFL8576RF | Recombinant Full Length Rat Udp-Glucuronosyltransferase 1-3(Ugt1) Protein, His-Tagged | E.coli | Rat | His | Full L. Full Length of Mature Protein (26-531) |
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| UGT1A3-3375H | Recombinant Human UGT1A3 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | DDK&Myc |
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| UGT1A3-512H | Recombinant Human UGT1A3 Protein, MYC/DDK-tagged | HEK293 | Human | DDK&Myc |
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| UGT1A3-539HF | Recombinant Full Length Human UGT1A3 Protein | In Vitro Cell Free System | Human | Full L. 534 amino acids |
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| UGT1A3-98H | Active Recombinant Human UGT1A3 Protein | Insect cells | Human |
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Involved Pathway
UGT1A3 involved in several pathways and played different roles in them. We selected most pathways UGT1A3 participated on our site, such as Pentose and glucuronate interconversions,Ascorbate and aldarate metabolism,Steroid hormone biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with UGT1A3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Starch and sucrose metabolism | KL,PYGM,GPIB,AGLA,GBE1,G6PCA.1,AMY1B,HKDC1,G6PC3,AMY2A |
| Chemical carcinogenesis | MGST1,CYP2E1,GSTM2,UGT2A2,NAT2,FAM84B,CYP2C9,UGT1A4,CYP2C39,ADH1B |
| Metabolic pathways | NDUFB10,UQCRH,GRHPR,B3GALT5,HSD3B1,TYRP1,PIGP,PPAP2CB,PIGU,PLD1A |
| Metabolism of xenobiotics by cytochrome P | GSTM5,MGST1.1,GSTA2,AKR7A3,ADH1,CYP2F2,GSTM6,UGT2B7,UGT1A1,UGT2A1 |
| Ascorbate and aldarate metabolism | UGT1A4,UGT1A7,ALDH9A1,ALDH7A1,UGT1A7C,UGT1A2,ALDH3A2,ALDH2,RGN,UGT1AB |
| Retinol metabolism | UGT1A4,ALDH1A1,CYP2C18,SDR16C5,CYP3A25,CYP2B19,RDH8,UGT1A6,RETSAT,CYP3A41A |
| Drug metabolism - cytochrome P | UGT1A2,GSTM2,AOX1,GSTP1,UGT5G1,UGT2A1,UGT1A7,GSTT1,GSTM5,FMO3 |
| Steroid hormone biosynthesis | CYP3A7,CYP3A41B,HSD17B2,HSD17B12B,CYP2C70,CYP2D10,HSD17B6,AKR1C3,CYP2D26,SRD5A3 |
| Drug metabolism - other enzymes | UMPS,UPP2,CES1D,UGT2A2,CES1C,CES2,DPYDB,CYP2A6,UGT1A7C,UCK2 |
Protein Function
UGT1A3 has several biochemical functions, for example, enzyme binding,glucuronosyltransferase activity,NOT glucuronosyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by UGT1A3 itself. We selected most functions UGT1A3 had, and list some proteins which have the same functions with UGT1A3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein heterodimerization activity | YWHAH,ADD1,POLE3,KCNA3,BAX,FLOT1,CEBPE,ADIPOR2,H2-AB1,P2RY1 |
| protein homodimerization activity | MYPOP,CDH13,DGCR8,TENM1,RAB11FIP2,TCF3,CRYM,NETO2,TPR,FAM109A |
| retinoic acid binding | CRABP2,UGT1A9,CRABP1A,PTGDSB,UGT1A7,LRAT,CRABP2B,RARA,SERPINA5,CRABP1B |
| glucuronosyltransferase activity | UGT1A1,UGT1A6A,UGT2A6,UGT1B5,UGT2B6,EXT2,UGT5A2,UGT5G1,UGT8,UGT2B1 |
| NOT glucuronosyltransferase activity | UGT1A9,UGT1A7,UGT1A1,UGT1A4,UGT1A6 |
| enzyme binding | PDCD2,CBX1,JUND,SPDL1,SIRT1,HDAC1,KAT8,HNRNPUL1,TH,NFKBIA |
Interacting Protein
UGT1A3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UGT1A3 here. Most of them are supplied by our site. Hope this information will be useful for your research of UGT1A3.
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References
- Lee, SJ; Park, JB; et al. In vitro selective inhibition of human UDP-glucuronosyltransferase (UGT) 1A4 by finasteride, and prediction of in vivo drug-drug interactions. TOXICOLOGY LETTERS 232:458-465(2015).
- Tian, XG; Liang, SC; et al. Regioselective Glucuronidation of Andrographolide and Its Major Derivatives: Metabolite Identification, Isozyme Contribution, and Species Differences. AAPS JOURNAL 17:156-166(2015).
