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UGT1A5

Official Full Name

UDP glucuronosyltransferase 1 family, polypeptide A5
Overview

This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5 exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter.
Synonyms

UGT1A5; UDP glucuronosyltransferase 1 family, polypeptide A5; UDP glycosyltransferase 1 family, polypeptide A5; UDP-glucuronosyltransferase 1-5; UGT1E; Ugt1; B5; UD15_HUMAN; UDP glucuronosyltransferase 1 family polypeptide A5s; UDP glycosyltransferase 1 family polypeptide A5; UDP-glucuronosyltransferase 1-E; UDP-glucuronosyltransferase 1A5; UDPGT 1-5; UDPGT; UGT-1E; UGT1*5; UGT1-05; UGT1.5; Ugt1a6; UDP-glucuronosyltransferase 1 family polypeptide A5s;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Homo sapiens (Human)	RFL20958HF	Recombinant Full Length Human Udp-Glucuronosyltransferase 1-5(Ugt1A5) Protein, His-Tagged	E.coli expression system	His	Full Length of Mature Protein (29-534)	Inquiry
Rattus norvegicus (Rat)	RFL2401RF	Recombinant Full Length Rat Udp-Glucuronosyltransferase 1-5(Ugt1) Protein, His-Tagged	E.coli expression system	His	Full Length of Mature Protein (26-531)	Inquiry
Zebrafish	UGT1A5-7720Z	Recombinant Zebrafish UGT1A5	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

UGT1A5 involved in several pathways and played different roles in them. We selected most pathways UGT1A5 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with UGT1A5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

UGT1A5 has several biochemical functions, for example, glucuronosyltransferase activity, hydrolase activity, transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by UGT1A5 itself. We selected most functions UGT1A5 had, and list some proteins which have the same functions with UGT1A5. You can find most of the proteins on our site.

Function	Related Protein
glucuronosyltransferase activity	CSGALNACT1;UGT1A6A;UGT5C1;UGT5F1;UGT2A6;B3GAT3;UGT2A1;UGT5A1;UGT5A5
hydrolase activity	FAAH2A;INPP5L;HE1B;DHX57;MBLAC2;PEO1;CTSL.1;UGT1A5;FAM105B
transferase activity	PRKCDA;ADKA;CAMK1DA;EK1;CSNK1DA;CKMT2B;PKM;STK25B;ZDHHC23B
transferase activity, transferring glycosyl groups	UGT1B1;EXT1C;EXT1A;DPY19L1;GTDC1;B3GNT9-PS;UGT2A6;B3GALTL;UGT5A4
transferase activity, transferring hexosyl groups	ALG3;GBGT1L3;UGT5A4;UGT1B5;UGT1B2;GBGT1L2;UGT2B3;UGT1B7;UGT1B1

UGT1A5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UGT1A5 here. Most of them are supplied by our site. Hope this information will be useful for your research of UGT1A5.

Research Area

Wang, M; Sun, DF; et al. Polymorphic Expression of UDP-Glucuronosyltransferase UGTlA Gene in Human Colorectal Cancer. PLOS ONE 8:-(2013).

Heydel, JM; Garnier, P; et al. Ciprofibrate regulation of rat hepatic bilirubin glucuronidation and UDP-glucuronosyltransferases expression. EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS 37:233-240(2012).