• Official Full Name

    UDP glucuronosyltransferase 1 family, polypeptide A5

  • Background

    This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5 exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter.
  • Synonyms

    UGT1A5; UDP glucuronosyltransferase 1 family, polypeptide A5; UDP glycosyltransferase 1 family, polypeptide A5; UDP-glucuronosyltransferase 1-5; UGT1E; Ugt1; B5; UD15_HUMAN; UDP glucuronosyltransferase 1 family polypeptide A5s; UDP glycosyltransferase 1 family polypeptide A5; UDP-glucuronosyltransferase 1-E; UDP-glucuronosyltransferase 1A5; UDPGT 1-5; UDPGT; UGT-1E; UGT1*5; UGT1-05; UGT1.5; Ugt1a6; UDP-glucuronosyltransferase 1 family polypeptide A5s;
    • Type:
    • Recombinant Proteins
    • Species :
    • Homo sapiens (Human)
    • Rattus norvegicus (Rat)
    • Zebrafish
    • Source :
    • E.coli expression system
    • Mammalian Cell
    • Tag :
    • His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Homo sapiens (Human) RFL20958HF Recombinant Full Length Human Udp-Glucuronosyltransferase 1-5(Ugt1A5) Protein, His-Tagged E.coli expression system His
    Rattus norvegicus (Rat) RFL2401RF Recombinant Full Length Rat Udp-Glucuronosyltransferase 1-5(Ugt1) Protein, His-Tagged E.coli expression system His
    Zebrafish UGT1A5-7720Z Recombinant Zebrafish UGT1A5 Mammalian Cell His
    • Involved Pathway
    • Protein Function
    • Interacting Protein
    • UGT1A5 Related Articles

    UGT1A5 involved in several pathways and played different roles in them. We selected most pathways UGT1A5 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with UGT1A5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    UGT1A5 has several biochemical functions, for example, glucuronosyltransferase activity, hydrolase activity, transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by UGT1A5 itself. We selected most functions UGT1A5 had, and list some proteins which have the same functions with UGT1A5. You can find most of the proteins on our site.

    Function Related Protein
    glucuronosyltransferase activityB3GNT1;UGT3A1;UGT5E1;UGT5A4;B3GAT3;UGT5C3;UGT1B4;UGT2B1;UGT1A6A
    hydrolase activityENPP2;HINT1;USPL1;CES1D;Reln;CTSSB.2;PPM1LA;MANEAL;ATP2A2B
    transferase activityFGFR1A;PIP5K1BA;ST6GALNAC1.2;TRMT10B;OAS1B;Acnat1;EXT1A;FTSJD2;UGT5A3
    transferase activity, transferring glycosyl groupsUGT5F1;PNP4B;HPRT1L;GYG1A;FUT9B;UGT5C3;C1GALT1B;MGAT3A;MGAT1B
    transferase activity, transferring hexosyl groupsUGT5A4;UGT1A5;UGT5B3;UGT5C3;UGT5B4;4931440L10Rik;UGT8A;UGT5G1;UGT1A6A

    UGT1A5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UGT1A5 here. Most of them are supplied by our site. Hope this information will be useful for your research of UGT1A5.

    Wang, M; Sun, DF; et al. Polymorphic Expression of UDP-Glucuronosyltransferase UGTlA Gene in Human Colorectal Cancer. PLOS ONE 8:-(2013).
    Heydel, JM; Garnier, P; et al. Ciprofibrate regulation of rat hepatic bilirubin glucuronidation and UDP-glucuronosyltransferases expression. EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS 37:233-240(2012).
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