UGT1A9

  • Official Full Name

    UDP glucuronosyltransferase 1 family, polypeptide A9

  • Overview

    This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5 exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene is active on phenols.
  • Synonyms

    UGT1A9; UDP glucuronosyltransferase 1 family, polypeptide A9; UDP glycosyltransferase 1 family, polypeptide A9; UDP-glucuronosyltransferase 1-9; HLUGP4; LUGP4; UGT1AI; UDP-glucuronosyltransferase 1-I; UDP-glucuronosyltransferase 1A9; UDPGT; UGT1I; UGT-1I;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Cynomolgus Monkey
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • E.coli
  • E.coli expression system
  • HEK293
  • In Vitro Cell Free System
  • Insect cells
  • Mammalian Cell
  • Wheat Germ
  • C
  • 6×His
  • GST
  • GST|His
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human UGT1A9-3587H Recombinant Human UGT1A9, GST-tagged E.coli GST 33-377aa
Human UGT1A9-179H Recombinant Human UGT1A9 Protein, GST/His-tagged E.coli GST/His
Human UGT1A9-12H Recombinant Human UGT1A9, GST-tagged Wheat Germ GST
Human UGT1A9-510HCL Recombinant Human UGT1A9 293 Cell Lysate HEK293 N/A
Human UGT1A9-160H Recombinant Human UGT1A9 protein, His-tagged E.coli His 33-377 aa
Human UGT1A9-541HF Recombinant Full Length Human UGT1A9 Protein, GST-tagged In Vitro Cell Free System GST 530 amino acids
Human UGT1A9-100H Active Recombinant Human UGT1A9 Protein Insect cells
Human UGT1A9-01H Recombinant Human UGT1A9 Protein, 6×His tagged E.coli C-6×His
Mouse UGT1A9-17811M Recombinant Mouse UGT1A9 Protein Mammalian Cell His
Mouse UGT1A9-9890M Recombinant Mouse UGT1A9 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse UGT1A9-9890M-B Recombinant Mouse UGT1A9 Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey UGT1A9-1078C Recombinant Cynomolgus UGT1A9 Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey UGT1A9-821C Recombinant Cynomolgus Monkey UGT1A9 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey UGT1A9-821C-B Recombinant Cynomolgus Monkey UGT1A9 Protein Pre-coupled Magnetic Beads HEK293
Homo sapiens (Human) RFL3231HF Recombinant Full Length Human Udp-Glucuronosyltransferase 1-9(Ugt1A9) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (26-530)
Mus musculus (Mouse) RFL12645MF Recombinant Full Length Mouse Udp-Glucuronosyltransferase 1-9(Ugt1A9) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (24-528)
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

UGT1A9 involved in several pathways and played different roles in them. We selected most pathways UGT1A9 participated on our site, such as Pentose and glucuronate interconversions, Ascorbate and aldarate metabolism, Steroid hormone biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with UGT1A9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Pentose and glucuronate interconversionsCRYL1;ALDH2.1;DHDHL;UGT1A6;RPE;AKR1B1L;SORD;UGT1A4;KL
Ascorbate and aldarate metabolismRGN;UGT2A2;ALDH9A1;UGT1A6B;ALDH3A2;UGT1A1;UGT5G1;UGT1A7C;UGT1A9
Steroid hormone biosynthesisHSD17B2;HSD3B2;HSD3B4;CYP2D26;SRD5A2B;CYP2C39;CYP3A25;SRD5A2A;HSD17B1
Starch and sucrose metabolismG6PCA.1;GBA3;UXS1;HK1;AMY2A2;GUSB;PYGMA;GANC;UGT2A3
Retinol metabolismCYP26C1;RDH8;DGAT1A;CYP2A4;DGAT1;ALDH1A1;SDR16C5A;UGT1A1;RDH8A
Porphyrin and chlorophyll metabolismUGT1A6A;FECH;HCCS;EARS2;UGT1A9;CPOX;UROD;HMBSB;ALAS1
Metabolism of xenobiotics by cytochrome PUGT2B7;GSTT2B;GSTP1;UGT2B15;ALDH3A1;UGT2A1;SULT2A1;UGT1AB;MGST1.1
Drug metabolism - cytochrome PFMO1;UGT1A7;UGT1A7C;FMO3;FMO2;GSTM1;UGT1A1;UGT2A3;UGT1A4
Drug metabolism - other enzymesPNAT3;GMPS;UGT1A1;UGT1A4;UGT1A7;TYMP;UGT1AB;UCK2A;IMPDH1
Metabolic pathwaysHSD3B6;CHSY1;NDUFA10;TST;ASAH2;CDS2;MTMR6;GALNTL1;POLR2J3
Chemical carcinogenesisCYP3A4;GSTK1;CYP2C38;ADH4;UGT1A1;UGT1A6B;UGT2B7;CCBL2;SULT1A2

UGT1A9 has several biochemical functions, for example, enzyme binding, enzyme inhibitor activity, glucuronosyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by UGT1A9 itself. We selected most functions UGT1A9 had, and list some proteins which have the same functions with UGT1A9. You can find most of the proteins on our site.

Function Related Protein
enzyme bindingSCNM1;CYP3A4;CA;FOXO4;UGT1A4;HLCS;RPA2;POR;TGFB1
enzyme inhibitor activityWDTC1;KIAA1967;WFIKKN1;OAZ2A;TXNIP;DGKZ;TAE1;ANGPTL4;PPP1R12A
glucuronosyltransferase activityUGT1B4;UGT2B15;UGT2B1;UGT1B2;UGT1B3;UGT3A1;UGT1A6A;UGT1A3;UGT1A7
NOT glucuronosyltransferase activityUGT1A7;UGT1A9;UGT1A4;UGT1A3;UGT1A1;UGT1A6
protein heterodimerization activityCRLF1;TAS1R1;TCF12;BCL2L10;HIST1H3G;HIST1H4E;SYCP2;SOX14;HIST1H2AM
protein homodimerization activityACHE;TFAP2E;RPL7;PYGL;CALCOCO2;UGT1A1;CRYM;HSF2;CREB3
retinoic acid bindingCRABP1A;CRABP2A;CYP26B1;CRABP1B;UGT1A2;CRABP2B;RARA;CRABP2;NR2F2

UGT1A9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UGT1A9 here. Most of them are supplied by our site. Hope this information will be useful for your research of UGT1A9.

Research Area

Related articles

Zhang, HB; Patana, AS; et al. Human UDP-Glucuronosyltransferase Expression in Insect Cells: Ratio of Active to Inactive Recombinant Proteins and the Effects of a C-Terminal His-Tag on Glucuronidation Kinetics. DRUG METABOLISM AND DISPOSITION 40:1935-1944(2012).
Oda, S; Nakajima, M; et al. Preparation of a Specific Monoclonal Antibody against Human UDP-Glucuronosyltransferase (UGT) 1A9 and Evaluation of UGT1A9 Protein Levels in Human Tissues. DRUG METABOLISM AND DISPOSITION 40:1620-1627(2012).
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