UGT1A9 Protein


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Official Full Name UDP glucuronosyltransferase 1 family, polypeptide A9
Background This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5 exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene is active on phenols.
Synonyms UGT1A9; UDP glucuronosyltransferase 1 family, polypeptide A9; UDP glycosyltransferase 1 family, polypeptide A9; UDP-glucuronosyltransferase 1-9; HLUGP4; LUGP4; UGT1AI; UDP-glucuronosyltransferase 1-I; UDP-glucuronosyltransferase 1A9; UDPGT; UGT1I; UGT-1I
    • Species :
    • Cynomolgus Monkey
    • Homo sapiens (Human)
    • Human
    • Mouse
    • Mus musculus (Mouse)
    • Source :
    • E.coli
    • E.coli expression system
    • HEK293
    • In Vitro Cell Free System
    • Insect cells
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human UGT1A9-12H Recombinant Human UGT1A9, GST-tagged Wheat Germ GST Inquiry
    Human UGT1A9-179H Recombinant Human UGT1A9 Protein, GST/His-tagged E.coli GST/His Inquiry
    Human UGT1A9-3587H Recombinant Human UGT1A9, GST-tagged E.coli GST Inquiry
    Mouse UGT1A9-17811M Recombinant Mouse UGT1A9 Protein Mammalian Cell His Inquiry
    Cynomolgus Monkey UGT1A9-1078C Recombinant Cynomolgus UGT1A9 Protein, His-tagged Mammalian Cell His Inquiry
    Human UGT1A9-510HCL Recombinant Human UGT1A9 293 Cell Lysate HEK293 N/A Inquiry
    Mus musculus (Mouse) RFL12645MF Recombinant Full Length Mouse Udp-Glucuronosyltransferase 1-9(Ugt1A9) Protein, His-Tagged E.coli expression system His Inquiry
    Homo sapiens (Human) RFL3231HF Recombinant Full Length Human Udp-Glucuronosyltransferase 1-9(Ugt1A9) Protein, His-Tagged E.coli expression system His Inquiry
    Human UGT1A9-160H Recombinant Human UGT1A9 protein, His-tagged E.coli His Inquiry
    Human UGT1A9-541HF Recombinant Full Length Human UGT1A9 Protein, GST-tagged In Vitro Cell Free System GST Inquiry
    Human UGT1A9-100H Recombinant Human UGT1A9 Protein Insect cells Inquiry

    UGT1A9 involved in several pathways and played different roles in them. We selected most pathways UGT1A9 participated on our site, such as Pentose and glucuronate interconversions, Ascorbate and aldarate metabolism, Steroid hormone biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with UGT1A9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Pentose and glucuronate interconversions KL; ALDH3A2A; UGT2B7; AKR1A1B; Akr1b3; AKR1B8; UGT2A3; UGT1A6A; CRYL1; UGT2A2
    Ascorbate and aldarate metabolism ALDH3A2A; ALDH9A1B; MIOX; UGT1AB; UGDH; UGT2A3; UGT1A6; UGT2A1; ALDH2.2; GKUP
    Steroid hormone biosynthesis CYP2C45; HSD17B12B; HSD17B3; AKR1D1; UGT2A1; CYP3A7-CYP3AP1; CYP11C1; UGT5G1; CYP3A41B; UGT1A2
    Starch and sucrose metabolism UGT1A7C; AMY2A2; G6PC; UGT1A7; UGT1A2; GPIA; UGT1A9; GANC; GYS2; GYS1
    Retinol metabolism UGT1A6B; SDR16C5; CYP3A41B; CYP2C18; ALDH1A2; DHRS4L2; ADH1; UGT2A1; UGT2A3; AOX3L1
    Porphyrin and chlorophyll metabolism UGT1A1; COX15; HMOX2A; P22; UGT1A6; FECH; HMBSA; MMAB; UGT1A7C; UGT1A9
    Metabolism of xenobiotics by cytochrome P GSTO1; UGT2B7; GSTAL; CBR3; UGT1A6; UGT1A2; UGT2B15; UGT2A1; GSTM6; GSTA
    Drug metabolism - cytochrome P AOX1; ALDH3B1; GSTT1; FMO3; UGT1A9; UGT2A2; UGT1AB; ALDH1A3; UGT2B7; MGST2
    Drug metabolism - other enzymes UCK2B; IMPDH1B; CES1C; UMPS; HPRT1; IMPDH2; UGT1A3; GUSB; ITPA; UGT1A7
    Metabolic pathways GBA2; UROD; CYP2P9; GAL3ST1A; POLD2; CDS2; COX15; ALDH2; CEL.1; PNPLA2
    Chemical carcinogenesis SULT1A4; MGST1; GSTA4; CYP2C70; CYP1B1; UGT1A6; CYP2C38; PTGS2; UGT1A7C; CYP2E1

    UGT1A9 has several biochemical functions, for example, enzyme binding, enzyme inhibitor activity, glucuronosyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by UGT1A9 itself. We selected most functions UGT1A9 had, and list some proteins which have the same functions with UGT1A9. You can find most of the proteins on our site.

    Function Related Protein
    enzyme binding SNRPD3; ECM1; HIST1H2AL; ESR1; HAND2; NPM2; EHHADH; KDM1A; NOTCH3; NOXO1
    enzyme inhibitor activity ANGPTL4; CSN2; SCG5; TXNIP; UGT1A9; ANGPTL3; OAZ2A; APBA3; NOTCH1; APOV1
    glucuronosyltransferase activity UGT3A2; UGT2B7; UGT5F1; UGT2A5; UGT2B15; UGT1A7C; UGT1A2; UGT5C3; UGT5A1; GYLTL1B
    NOT glucuronosyltransferase activity UGT1A6; UGT1A3; UGT1A4; UGT1A9; UGT1A1; UGT1A7
    protein heterodimerization activity LIMK2; SOX5; HIST1H3D; ADIPOR1; CHRNB2; KCNK3; UGT1A4; TAL1; RAB3GAP2; GUCY1A3
    protein homodimerization activity ADD1; LMLN; GSTM2; TPR; CADM2; IRF3; FZD1; RRAGA; MIXL1; ANO6
    retinoic acid binding UGT1A3; CYP26A1; PTGDSB; LRAT; RARA; UGT1A1; CRABP2A; CRABP1B; UGT1A7; CRABP1A

    UGT1A9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UGT1A9 here. Most of them are supplied by our site. Hope this information will be useful for your research of UGT1A9.

    Zhang, HB; Patana, AS; et al. Human UDP-Glucuronosyltransferase Expression in Insect Cells: Ratio of Active to Inactive Recombinant Proteins and the Effects of a C-Terminal His-Tag on Glucuronidation Kinetics. DRUG METABOLISM AND DISPOSITION 40:1935-1944(2012).
    Oda, S; Nakajima, M; et al. Preparation of a Specific Monoclonal Antibody against Human UDP-Glucuronosyltransferase (UGT) 1A9 and Evaluation of UGT1A9 Protein Levels in Human Tissues. DRUG METABOLISM AND DISPOSITION 40:1620-1627(2012).

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