UGT1A9 Protein


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Official Full Name UDP glucuronosyltransferase 1 family, polypeptide A9
Background This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5 exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene is active on phenols.
Synonyms UGT1A9; UDP glucuronosyltransferase 1 family, polypeptide A9; UDP glycosyltransferase 1 family, polypeptide A9; UDP-glucuronosyltransferase 1-9; HLUGP4; LUGP4; UGT1AI; UDP-glucuronosyltransferase 1-I; UDP-glucuronosyltransferase 1A9; UDPGT; UGT1I; UGT-1I
    • Species :
    • Cynomolgus Monkey
    • Homo sapiens (Human)
    • Human
    • Mouse
    • Source :
    • E.coli
    • E.coli expression system
    • HEK293
    • In Vitro Cell Free System
    • Insect cells
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human UGT1A9-12H Recombinant Human UGT1A9, GST-tagged Wheat Germ GST
    Human UGT1A9-179H Recombinant Human UGT1A9 Protein, GST/His-tagged E.coli GST/His
    Human UGT1A9-3587H Recombinant Human UGT1A9, GST-tagged E.coli GST
    Mouse UGT1A9-17811M Recombinant Mouse UGT1A9 Protein Mammalian Cell His
    Cynomolgus Monkey UGT1A9-1078C Recombinant Cynomolgus UGT1A9 Protein, His-tagged Mammalian Cell His
    Human UGT1A9-510HCL Recombinant Human UGT1A9 293 Cell Lysate HEK293 N/A
    Homo sapiens (Human) RFL3231HF Recombinant Full Length Human Udp-Glucuronosyltransferase 1-9(Ugt1A9) Protein, His-Tagged E.coli expression system His
    Human UGT1A9-541HF Recombinant Full Length Human UGT1A9 Protein, GST-tagged In Vitro Cell Free System GST
    Human UGT1A9-100H Recombinant Human UGT1A9 Protein Insect cells

    UGT1A9 involved in several pathways and played different roles in them. We selected most pathways UGT1A9 participated on our site, such as Pentose and glucuronate interconversions, Ascorbate and aldarate metabolism, Steroid hormone biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with UGT1A9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Pentose and glucuronate interconversions DCXR; ALDH2; RPE; UGT2A2; UGT1A3; UGT1A9; DHDH; UGT1A6A; GUSB; UGT1A7
    Ascorbate and aldarate metabolism UGT1A2; UGT2B7; ALDH2.2; UGT2A1; UGT2A3; ALDH3A2A; GULO; UGT2A2; GKUP; UGT1A6B
    Steroid hormone biosynthesis UGT1A2; CYP3A7; CYP2B19; UGT5G1; CYP2D10; CYP2C45; HSD11B1; SULT2B1; CYP2D9; UGT2B7
    Starch and sucrose metabolism GANC; GAA; GPIB; UGT1A9; GUSB; UGT1A7; SI; HK3; HK2; AMY2A3
    Retinol metabolism CYP4A14; LRATA; UGT2A3; BCO1L; CYP3A25; RPE65; DGAT1; UGT1A6; AOX2P; CYP26B1
    Porphyrin and chlorophyll metabolism ALAS1; HMOX2; UGT1A6; GUSB; UGT1AB; HMBSB; UGT1A3; UGT2B15; HCCSA.1; HEPH
    Metabolism of xenobiotics by cytochrome P MGST2; UGT2A3; GSTAL; AKR7A5; AKR7A3; UGT2A1; GSTT2B; GSTM2; CBR3; GSTM3
    Drug metabolism - cytochrome P MAOB; UGT5G1; AOX2P; AOX3L1; GSTP2; FMO6P; GSTO1; MGST1.1; UGT1AB; GSTAL
    Drug metabolism - other enzymes ITPA; UGT2A2; CDA; TYMP; NAT2; UGT2B15; IMPDH2; UGT1A6B; UGT1A1; UGT2B7
    Metabolic pathways GNSA; PGP; GLUD2; GCNT3; SPHK2; MIBP; MTMR4; CHSY3; cysH; CYP2C50
    Chemical carcinogenesis CYP2C55; UGT2A3; ADH2-1; MGST1; CCBL2; GSTM2; UGT1A1; CYP3A43; UGT1A7; CYP2A6

    UGT1A9 has several biochemical functions, for example, enzyme binding, enzyme inhibitor activity, glucuronosyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by UGT1A9 itself. We selected most functions UGT1A9 had, and list some proteins which have the same functions with UGT1A9. You can find most of the proteins on our site.

    Function Related Protein
    enzyme binding NFKBIA; UGT1A6B; KDM1A; SLPI; HMOX1; UGT1A4; CD40; SUPT5H; TOP2A; ZNF346
    enzyme inhibitor activity NOTCH1; UGT1A9; CSN2; APOV1; SLN; PDE6H; OAZ2A; DGKZ; ATPIF1; OAZ2B
    glucuronosyltransferase activity GYLTL1B; UGT2A6; LARGE; UGT5A3; EXT1; CSGALNACT1; UGT1A3; UGT1A7; UGT2A3; UGT1A6A
    NOT glucuronosyltransferase activity UGT1A3; UGT1A4; UGT1A6; UGT1A7; UGT1A9; UGT1A1
    protein heterodimerization activity H2AFZ; HER11; UGT1A4; BOKB; PKNOX1; TAF13; HEXB; EXT1; H2AFVA; HIST1H2AC
    protein homodimerization activity NR0B2; CACYBP; ABCD3; ASCL1; C9orf142; MCL1B; NOS2; HARS2; GM5506; CD4
    retinoic acid binding CRABP1A; CRABP1B; UGT1A7; UGT1A9; UGT1A1; UGT1A2; NR2F2; CYP26B1; CRABP2B; LRAT

    UGT1A9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UGT1A9 here. Most of them are supplied by our site. Hope this information will be useful for your research of UGT1A9.

    Zhang, HB; Patana, AS; et al. Human UDP-Glucuronosyltransferase Expression in Insect Cells: Ratio of Active to Inactive Recombinant Proteins and the Effects of a C-Terminal His-Tag on Glucuronidation Kinetics. DRUG METABOLISM AND DISPOSITION 40:1935-1944(2012).
    Oda, S; Nakajima, M; et al. Preparation of a Specific Monoclonal Antibody against Human UDP-Glucuronosyltransferase (UGT) 1A9 and Evaluation of UGT1A9 Protein Levels in Human Tissues. DRUG METABOLISM AND DISPOSITION 40:1620-1627(2012).

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