• Official Full Name

    UDP glucuronosyltransferase 1 family, polypeptide A9

  • Background

    This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5 exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene is active on phenols.
  • Synonyms

    UGT1A9; UDP glucuronosyltransferase 1 family, polypeptide A9; UDP glycosyltransferase 1 family, polypeptide A9; UDP-glucuronosyltransferase 1-9; HLUGP4; LUGP4; UGT1AI; UDP-glucuronosyltransferase 1-I; UDP-glucuronosyltransferase 1A9; UDPGT; UGT1I; UGT-1I;
    • Type:
    • Recombinant Proteins
    • Protein Pre-coupled Magnetic Beads
    • Cell & Tissue Lysates
    • Species :
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Source :
    • E.coli
    • HEK293
    • Insect cells
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • GST|His
    • His
    • His (Fc)
    • Avi
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Cynomolgus Monkey UGT1A9-821C Recombinant Cynomolgus Monkey UGT1A9 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Cynomolgus Monkey UGT1A9-1078C Recombinant Cynomolgus UGT1A9 Protein, His-tagged Mammalian Cell His
    Cynomolgus Monkey UGT1A9-821C-B Recombinant Cynomolgus Monkey UGT1A9 Protein Pre-coupled Magnetic Beads HEK293
    Human UGT1A9-3587H Recombinant Human UGT1A9, GST-tagged E.coli GST
    Human UGT1A9-179H Recombinant Human UGT1A9 Protein, GST/His-tagged E.coli GST/His
    Human UGT1A9-510HCL Recombinant Human UGT1A9 293 Cell Lysate HEK293 N/A
    Human UGT1A9-160H Recombinant Human UGT1A9 protein, His-tagged E.coli His
    Human UGT1A9-12H Recombinant Human UGT1A9, GST-tagged Wheat Germ GST
    Human UGT1A9-100H Recombinant Human UGT1A9 Protein Insect cells
    Mouse UGT1A9-17811M Recombinant Mouse UGT1A9 Protein Mammalian Cell His
    Mouse UGT1A9-9890M-B Recombinant Mouse UGT1A9 Protein Pre-coupled Magnetic Beads HEK293
    Mouse UGT1A9-9890M Recombinant Mouse UGT1A9 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    • Involved Pathway
    • Protein Function
    • Interacting Protein
    • UGT1A9 Related Articles

    UGT1A9 involved in several pathways and played different roles in them. We selected most pathways UGT1A9 participated on our site, such as Pentose and glucuronate interconversions, Ascorbate and aldarate metabolism, Steroid hormone biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with UGT1A9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Pentose and glucuronate interconversionsUGT1A7C;KL;AKR1B1L;UGT1A1;UGP2B;ALDH3A2A;OXSR1;UGT1A3;UGT1A7
    Ascorbate and aldarate metabolismUGT1A2;ALDH9A1;UGT1A6B;UGT2B15;UGT1A6A;UGT2A1;UGT2A3;ALDH3A2;UGT1A9
    Steroid hormone biosynthesisHSD17B8;CYP11C1;CYP2C45;UGT2A1;UGT5G1;UGT2A2;CYP7A1A;CYP19A1B;COMTA
    Starch and sucrose metabolismSI;GPIB;GBA3;G6PC3;UGT2A2;UGP2B;AMY2A2;AGL;AMY2A4
    Retinol metabolismBCO1;ALDH1A2;HSD17B6;RDH8A;CYP4A12A;UGT2B7;CYP3A25;UGT1A6;CYP2C39
    Porphyrin and chlorophyll metabolismHMOX2;UGT1A4;UROS;CP;COX15;UGT1A7;UGT2B7;UGT1A6B;UGT5G1
    Metabolism of xenobiotics by cytochrome PUGT1A7;GSTP1;CBR3;GSTT1;GSTM2;ALDH3A1;UGT5G1;GSTM5;UGT1A2
    Drug metabolism - cytochrome PFMO4;UGT1A7C;GSTP1;GSTM3;UGT2A3;AOX3L1;GSTT2;GSTA4;GSTM4
    Drug metabolism - other enzymesUGT1AB;UCK2;UPP1;UGT1A6B;GMPS;UGT1A2;NAT1;DPYDB;UGT1A1
    Chemical carcinogenesisUGT1A6;UGT2B15;CYP1B1;ALDH3B1;Nat3;ADH2-1;CYP2C39;UGT2A1;PTGS2

    UGT1A9 has several biochemical functions, for example, enzyme binding, enzyme inhibitor activity, glucuronosyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by UGT1A9 itself. We selected most functions UGT1A9 had, and list some proteins which have the same functions with UGT1A9. You can find most of the proteins on our site.

    Function Related Protein
    enzyme bindingTSPAN5;SUPT5H;CYP2C19;TARBP2;CBX3;RARA;ATF7;YES1;RPA2
    enzyme inhibitor activitySCG5;UGT1A1;CALU;OAZ2B;PDE6G;OAZ1A;ANGPTL3;ATPIF1B;CD46
    glucuronosyltransferase activityUGT8A;UGT5B2;UGT1AB;UGT5C2;UGT1A6A;UGT5B4;UGT5A1;UGT1B5;UGT2B6
    NOT glucuronosyltransferase activityUGT1A4;UGT1A1;UGT1A3;UGT1A6;UGT1A7;UGT1A9
    protein heterodimerization activityHEXB;TYR;PIK3R1;H2AFVB;P2RY1;IKBKB;ADD2;PPP2R4;MLXIPL
    protein homodimerization activityDefa-rs7;Trl;GSTA4;SLC30A8;IKZF2;PDZD7;NACC2;RAB11FIP2;CSF1

    UGT1A9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UGT1A9 here. Most of them are supplied by our site. Hope this information will be useful for your research of UGT1A9.

    Zhang, HB; Patana, AS; et al. Human UDP-Glucuronosyltransferase Expression in Insect Cells: Ratio of Active to Inactive Recombinant Proteins and the Effects of a C-Terminal His-Tag on Glucuronidation Kinetics. DRUG METABOLISM AND DISPOSITION 40:1935-1944(2012).
    Oda, S; Nakajima, M; et al. Preparation of a Specific Monoclonal Antibody against Human UDP-Glucuronosyltransferase (UGT) 1A9 and Evaluation of UGT1A9 Protein Levels in Human Tissues. DRUG METABOLISM AND DISPOSITION 40:1620-1627(2012).
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