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UGT1A9

Official Full Name

UDP glucuronosyltransferase 1 family, polypeptide A9
Background

This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5 exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene is active on phenols.
Synonyms

UGT1A9; UDP glucuronosyltransferase 1 family, polypeptide A9; UDP glycosyltransferase 1 family, polypeptide A9; UDP-glucuronosyltransferase 1-9; HLUGP4; LUGP4; UGT1AI; UDP-glucuronosyltransferase 1-I; UDP-glucuronosyltransferase 1A9; UDPGT; UGT1I; UGT-1I;

Type:
Recombinant Proteins
Protein Pre-coupled Magnetic Beads
Cell & Tissue Lysates

Species :
Cynomolgus Monkey
Human
Mouse

Source :
E.coli
HEK293
Insect cells
Mammalian Cell
Wheat Germ

Tag :
GST
GST|His
His
His (Fc)
Avi
N/A

Species	Cat.#	Product name	Source (Host)	Tag	Price
Cynomolgus Monkey	UGT1A9-821C	Recombinant Cynomolgus Monkey UGT1A9 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	$2,998.00 / 50ug
Cynomolgus Monkey	UGT1A9-1078C	Recombinant Cynomolgus UGT1A9 Protein, His-tagged	Mammalian Cell	His	Inquiry
Cynomolgus Monkey	UGT1A9-821C-B	Recombinant Cynomolgus Monkey UGT1A9 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Human	UGT1A9-3587H	Recombinant Human UGT1A9, GST-tagged	E.coli	GST	$319.00 / 25ug
Human	UGT1A9-179H	Recombinant Human UGT1A9 Protein, GST/His-tagged	E.coli	GST/His	Inquiry
Human	UGT1A9-510HCL	Recombinant Human UGT1A9 293 Cell Lysate	HEK293	N/A	Inquiry
Human	UGT1A9-160H	Recombinant Human UGT1A9 protein, His-tagged	E.coli	His	Inquiry
Human	UGT1A9-12H	Recombinant Human UGT1A9, GST-tagged	Wheat Germ	GST	Inquiry
Human	UGT1A9-100H	Recombinant Human UGT1A9 Protein	Insect cells		Inquiry
Mouse	UGT1A9-17811M	Recombinant Mouse UGT1A9 Protein	Mammalian Cell	His	Inquiry
Mouse	UGT1A9-9890M-B	Recombinant Mouse UGT1A9 Protein Pre-coupled Magnetic Beads	HEK293		Inquiry
Mouse	UGT1A9-9890M	Recombinant Mouse UGT1A9 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi	$2,998.00 / 50ug

Involved Pathway
Protein Function
Interacting Protein
UGT1A9 Related Articles

UGT1A9 involved in several pathways and played different roles in them. We selected most pathways UGT1A9 participated on our site, such as Pentose and glucuronate interconversions, Ascorbate and aldarate metabolism, Steroid hormone biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with UGT1A9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Pentose and glucuronate interconversions	UGT1A7C;KL;AKR1B1L;UGT1A1;UGP2B;ALDH3A2A;OXSR1;UGT1A3;UGT1A7
Ascorbate and aldarate metabolism	UGT1A2;ALDH9A1;UGT1A6B;UGT2B15;UGT1A6A;UGT2A1;UGT2A3;ALDH3A2;UGT1A9
Steroid hormone biosynthesis	HSD17B8;CYP11C1;CYP2C45;UGT2A1;UGT5G1;UGT2A2;CYP7A1A;CYP19A1B;COMTA
Starch and sucrose metabolism	SI;GPIB;GBA3;G6PC3;UGT2A2;UGP2B;AMY2A2;AGL;AMY2A4
Retinol metabolism	BCO1;ALDH1A2;HSD17B6;RDH8A;CYP4A12A;UGT2B7;CYP3A25;UGT1A6;CYP2C39
Porphyrin and chlorophyll metabolism	HMOX2;UGT1A4;UROS;CP;COX15;UGT1A7;UGT2B7;UGT1A6B;UGT5G1
Metabolism of xenobiotics by cytochrome P	UGT1A7;GSTP1;CBR3;GSTT1;GSTM2;ALDH3A1;UGT5G1;GSTM5;UGT1A2
Drug metabolism - cytochrome P	FMO4;UGT1A7C;GSTP1;GSTM3;UGT2A3;AOX3L1;GSTT2;GSTA4;GSTM4
Drug metabolism - other enzymes	UGT1AB;UCK2;UPP1;UGT1A6B;GMPS;UGT1A2;NAT1;DPYDB;UGT1A1
Metabolic pathways	UQCRB;ACOT1;UGT1A3;PIGM;MRI1;CTPS2;NDUFA4;NAMPTB;POLR2C
Chemical carcinogenesis	UGT1A6;UGT2B15;CYP1B1;ALDH3B1;Nat3;ADH2-1;CYP2C39;UGT2A1;PTGS2

UGT1A9 has several biochemical functions, for example, enzyme binding, enzyme inhibitor activity, glucuronosyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by UGT1A9 itself. We selected most functions UGT1A9 had, and list some proteins which have the same functions with UGT1A9. You can find most of the proteins on our site.

Function	Related Protein
enzyme binding	TSPAN5;SUPT5H;CYP2C19;TARBP2;CBX3;RARA;ATF7;YES1;RPA2
enzyme inhibitor activity	SCG5;UGT1A1;CALU;OAZ2B;PDE6G;OAZ1A;ANGPTL3;ATPIF1B;CD46
glucuronosyltransferase activity	UGT8A;UGT5B2;UGT1AB;UGT5C2;UGT1A6A;UGT5B4;UGT5A1;UGT1B5;UGT2B6
NOT glucuronosyltransferase activity	UGT1A4;UGT1A1;UGT1A3;UGT1A6;UGT1A7;UGT1A9
protein heterodimerization activity	HEXB;TYR;PIK3R1;H2AFVB;P2RY1;IKBKB;ADD2;PPP2R4;MLXIPL
protein homodimerization activity	Defa-rs7;Trl;GSTA4;SLC30A8;IKZF2;PDZD7;NACC2;RAB11FIP2;CSF1
retinoic acid binding	SERPINA5;CRABP1;LRAT;CRABP1A;CRABP2B;UGT1A9;PTGDSB;UGT1A1;LCN12

UGT1A9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UGT1A9 here. Most of them are supplied by our site. Hope this information will be useful for your research of UGT1A9.

Zhang, HB; Patana, AS; et al. Human UDP-Glucuronosyltransferase Expression in Insect Cells: Ratio of Active to Inactive Recombinant Proteins and the Effects of a C-Terminal His-Tag on Glucuronidation Kinetics. DRUG METABOLISM AND DISPOSITION 40:1935-1944(2012).

Oda, S; Nakajima, M; et al. Preparation of a Specific Monoclonal Antibody against Human UDP-Glucuronosyltransferase (UGT) 1A9 and Evaluation of UGT1A9 Protein Levels in Human Tissues. DRUG METABOLISM AND DISPOSITION 40:1620-1627(2012).