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UHMK1

  • Official Full Name

    U2AF homology motif (UHM) kinase 1

  • Overview

    The gene encodes a serine/threonine protein kinase that promotes cell cycle progression through G1 by phosphorylation of the cyclin-dependent kinase inhibitor 1B (p27Kip1), which causes nuclear export and degradation. The encoded protein is also thought to function in the adult nervous system and the gene has been associated with schizophrenia. Alternative splicing results in multiple transcript variants.
  • Synonyms

    UHMK1; U2AF homology motif (UHM) kinase 1; serine/threonine-protein kinase Kist; KIS; Kist; KIS protein kinase; kinase interacting with leukemia-associated gene (stathmin); FLJ23015; DKFZp434C1613;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Sf9 Insect Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human UHMK1-7027H Recombinant Human UHMK1 , GST-tagged Sf9 Insect Cell GST Full length
Human UHMK1-509HCL Recombinant Human UHMK1 293 Cell Lysate HEK293 N/A
Human UHMK1-5049H Recombinant Human UHMK1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Mouse UHMK1-17825M Recombinant Mouse UHMK1 Protein Mammalian Cell His
Mouse UHMK1-9897M Recombinant Mouse UHMK1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse UHMK1-9897M-B Recombinant Mouse UHMK1 Protein Pre-coupled Magnetic Beads HEK293
Rat UHMK1-6438R Recombinant Rat UHMK1 Protein Mammalian Cell His
Rat UHMK1-6094R Recombinant Rat UHMK1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat UHMK1-6094R-B Recombinant Rat UHMK1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque UHMK1-5103R Recombinant Rhesus monkey UHMK1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque UHMK1-4916R Recombinant Rhesus Macaque UHMK1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque UHMK1-4916R-B Recombinant Rhesus Macaque UHMK1 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish UHMK1-4539Z Recombinant Zebrafish UHMK1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • UHMK1 Related Articles

UHMK1 involved in several pathways and played different roles in them. We selected most pathways UHMK1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with UHMK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

UHMK1 has several biochemical functions, for example, ATP binding, mRNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by UHMK1 itself. We selected most functions UHMK1 had, and list some proteins which have the same functions with UHMK1. You can find most of the proteins on our site.

Function Related Protein
ATP bindingPRKAG1;MOV10B.2;DDX3X;FGFR1B;NTPCR;DHX16;RUNX2;ADCY9;ACTA1A
mRNA bindingEDC3;RPS2;D19BWG1357E;FXR1;KIAA0020;PURB;SNRNP35;CSTF3;KHSRP
protein bindingMYLK2;ROPN1B;MAP4K5;C1QTNF9B-AS1;EIF3C;SLC52A2;CRBN;LAGE3;MYOT
protein serine/threonine kinase activityCAMK1GA;ILK;MARK3;SMOK2B;SGK1;RPS6KA3B;CDC42BPB;RPS6KC1;CDK5
ribonucleoprotein complex bindingPQBP1;PIGC;ITCH;PRMT7;PRMT5;IFIH1;CKAP5;PRPF6;CD2BP2
transferase activityST3GAL2L;B3GNT9-PS;PRMT8B;TRMT10B;SULT3ST3;MAPKAPK2A;AKT3A;PCMT;PRKG1A

UHMK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with UHMK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of UHMK1.

ABL1; SF1

Loerch, S; Maucuer, A; et al. Cancer-relevant Splicing Factor CAPER alpha Engages the Essential Splicing Factor SF3b155 in a Specific Ternary Complex. JOURNAL OF BIOLOGICAL CHEMISTRY 289:17325-17337(2014).
Puri, V; McQuillin, A; et al. Confirmation of the genetic association between the U2AF homology motif (UHM) kinase 1 (UHMK1) gene and schizophrenia on chromosome 1q23.3. EUROPEAN JOURNAL OF HUMAN GENETICS 16:1275-1282(2008).
Manceau, V; Swenson, M; et al. Major phosphorylation of SF1 on adjacent Ser-Pro motifs enhances interaction with U2AF(65). FEBS JOURNAL 273:577-587(2006).
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