USP11

Official Full Name

ubiquitin specific peptidase 11
Overview

Protein ubiquitination controls many intracellular processes, including cell cycle progression, transcriptional;activation, and signal transduction. This dynamic process, involving ubiquitin conjugating enzymes and;deubiquitinating enzymes, adds and removes ubiquitin. Deubiquitinating enzymes are cysteine proteases that;specifically cleave ubiquitin from ubiquitin-conjugated protein substrates. This gene encodes a deubiquitinating;enzyme which lies in a gene cluster on chromosome Xp11.23.
Synonyms

USP11; ubiquitin specific peptidase 11; ubiquitin specific protease 11; ubiquitin carboxyl-terminal hydrolase 11; UHX1; ubiquitin thioesterase 11; deubiquitinating enzyme 11; ubiquitin thiolesterase 11; ubiquitin-specific processing protease 11; ubiquitin;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	USP11-08H	Active Recombinant Human USP11 protein, His-tagged	Insect Cell	His		$298 / 10ug
Human	USP11-0886H	Recombinant Human USP11 Protein (A2-N963), Tag Free	Insect Cell	Non	A2-N963	Inquiry
Human	USP11-360H	Recombinant Human USP11 Protein, GST-tagged	Insect Cell	GST		Inquiry
Human	USP11-0885H	Recombinant Human USP11 Protein (A2-N963), GST tagged	Insect Cell	GST	A2-N963	Inquiry

Other Resource

USP11 involved in several pathways and played different roles in them. We selected most pathways USP11 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with USP11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

USP11 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by USP11 itself. We selected most functions USP11 had, and list some proteins which have the same functions with USP11. You can find most of the proteins on our site.

Function	Related Protein

USP11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with USP11 here. Most of them are supplied by our site. Hope this information will be useful for your research of USP11.

Research Area

Regulator of NFkB

Kaasinen, E; Rahikkala, E; et al. Clinical characterization, genetic mapping and whole- genome sequence analysis of a novel autosomal recessive intellectual disability syndrome. EUROPEAN JOURNAL OF MEDICAL GENETICS 57:543-551(2014).

Burkhart, RA; Peng, Y; et al. Mitoxantrone Targets Human Ubiquitin-Specific Peptidase 11 (USP11) and Is a Potent Inhibitor of Pancreatic Cancer Cell Survival. MOLECULAR CANCER RESEARCH 11:901-911(2013).