VPS25
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Official Full Name
vacuolar protein sorting 25 homolog
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Background
VPS25, VPS36 (MIM 610903), and SNF8 (MIM 610904) form ESCRT-II (endosomal sorting complex required for transport II), a;complex involved in endocytosis of ubiquitinated membrane proteins. VPS25, VPS36, and SNF8 are also associated in a;multiprotein complex with RNA polymerase II elongation factor (ELL; MIM 600284) (Slagsvold et al., 2005 (PubMed;15755741); Kamura et al., 2001 (PubMed 11278625)). -
Synonyms
VPS25; vacuolar protein sorting 25 homolog (S. cerevisiae); vacuolar protein sorting 25 (yeast); vacuolar protein-sorting-associated protein 25; DERP9; EAP20; MGC10540; ESCRT-II complex subunit VPS25; ELL-associated protein of 20 kDa; dermal papilla-deriv;
- Involved Pathway
- Protein Function
- Interacting Protein
VPS25 involved in several pathways and played different roles in them. We selected most pathways VPS25 participated on our site, such as Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with VPS25 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Endocytosis | PIP5K1B;CYTH4;PIP5K1AB;MVB12B;EHD1A;SPG21;GRK7A;DNM1B;LDLRAP1B |
VPS25 has several biochemical functions, for example, protein N-terminus binding, protein binding, protein homodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by VPS25 itself. We selected most functions VPS25 had, and list some proteins which have the same functions with VPS25. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein N-terminus binding | STX1A;HAX1;KCNB1;SMARCE1;YWHAQ;SNCA;TGFB1;DCTN4;RPS21 |
| protein binding | CD58;ATP6V0C;TSC22D1;SEMA4D;PDK3;TRAF3;FAM96A;Akap3;EXOSC5 |
| protein homodimerization activity | ID1;DMRT3A;DAPK3;FAM109A;ZBTB4;C16orf89;TPD52;CCBL1;VPS24 |
| structural molecule activity | NEFLB;ROCK2;CLDN3;CLDN23;FGG;CLDN7A;KRT6A;SNTG1;CLDNC |
VPS25 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with VPS25 here. Most of them are supplied by our site. Hope this information will be useful for your research of VPS25.
SNF8; TRIM27; REL; BEND5; CRLF3; uvrB
- Q&As
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