VPS26A
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Official Full Name
vacuolar protein sorting 26 homolog A (S. pombe)
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Background
This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008] -
Synonyms
VPS26A; vacuolar protein sorting 26 homolog A (S. pombe); HB58; PEP8A; VPS26; Hbeta58; vacuolar protein sorting-associated protein 26A; vesicle protein sorting 26A;
- Involved Pathway
- Protein Function
- Interacting Protein
VPS26A involved in several pathways and played different roles in them. We selected most pathways VPS26A participated on our site, such as Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with VPS26A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Endocytosis | HSPA8;SH3GLB2B;CHMP2BB;ZFYVE16;WASH1;PSD4;EHD1A;DAB2;CLTCB |
VPS26A has several biochemical functions, for example, protein binding, protein transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by VPS26A itself. We selected most functions VPS26A had, and list some proteins which have the same functions with VPS26A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | NOXA1;ITPKB;PSMC6;TARSL2;E2F1;CDC25B;DHH;CDKN2D;Tnfrsf23 |
| protein transporter activity | KPNB1;AP1S3B;CCT6B;AP2A2;XPO6;XPO1;XPO5;COG3;KPNA5 |
VPS26A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with VPS26A here. Most of them are supplied by our site. Hope this information will be useful for your research of VPS26A.
VPS35; VPS29; SNX2; SNX1; ILK; SMYD2; IGF2R
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