xrcc4 Protein, X-ray repair complementing defective repair in Chinese hamster cells 4

xrcc4

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xrcc4

Official Full Name X-ray repair complementing defective repair in Chinese hamster cells 4
Background The protein encoded by this gene functions together with DNA ligase IV and the DNA-dependent protein kinase in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. The non-homologous end-joining pathway is required both for normal development and for suppression of tumors. This gene functionally complements XR-1 Chinese hamster ovary cell mutant, which is impaired in DNA double-strand breaks produced by ionizing radiation and restriction enzymes. Alternative transcription initiation and alternative splicing generates several transcript variants.
Synonyms XRCC4; X-ray repair complementing defective repair in Chinese hamster cells 4; DNA repair protein XRCC4; X ray repair; complementing defective; repair in Chinese hamster; X-ray repair cross-complementing protein 4; X-ray repair, complementing defective, r
    • Species :
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Tag :
    • C-Myc/DDK
    • GST
    • His
    • MYC/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human XRCC4-078H Recombinant Human XRCC4 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
    Mouse Xrcc4-364M Recombinant Mouse Xrcc4 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Human XRCC4-1003H Recombinant Human XRCC4 protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human XRCC4-1004H Recombinant Human XRCC4 protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human XRCC4-255HCL Recombinant Human XRCC4 293 Cell Lysate HEK293 N/A
    Human XRCC4-30134TH Recombinant Human XRCC4, His-tagged E.coli His
    Human XRCC4-3757H Recombinant Human XRCC4, GST-tagged E.coli GST
    Mouse XRCC4-18638M Recombinant Mouse XRCC4 Protein Mammalian Cell His
    Cynomolgus Monkey XRCC4-1090C Recombinant Cynomolgus XRCC4 Protein, His-tagged Mammalian Cell His
    Zebrafish XRCC4-11047Z Recombinant Zebrafish XRCC4 Mammalian Cell His

    xrcc4 involved in several pathways and played different roles in them. We selected most pathways xrcc4 participated on our site, such as Non-homologous end-joining, which may be useful for your reference. Also, other proteins which involved in the same pathway with xrcc4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Non-homologous end-joining XRCC5; NHEJ1; POLL; LIG4; DNTT; FEN1; DCLRE1C; MRE11A; POLM; PRKDC

    xrcc4 has several biochemical functions, for example, NOT DNA binding, NOT ligase activity, protein C-terminus binding. Some of the functions are cooperated with other proteins, some of the functions could acted by xrcc4 itself. We selected most functions xrcc4 had, and list some proteins which have the same functions with xrcc4. You can find most of the proteins on our site.

    Function Related Protein
    NOT DNA binding SKIL; MBD5; XRCC4; NFIB; HIPK2; TINF2
    NOT ligase activity XRCC4
    protein C-terminus binding JAK2; XRCC6; ERCC3; CITED1; FBLN1; AXIN1; TOP2B; ABL1; DLG1; TFCP2
    protein binding MAPK8IP2; ANXA5; WBSCR27; HTN1; NIPA2; PCGF1; GRID2IP; CHMP6; LOH12CR1; CASP7

    xrcc4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with xrcc4 here. Most of them are supplied by our site. Hope this information will be useful for your research of xrcc4.

    PNKP; NHEJ1; APLF

    Palomino, GM; Bassi, CL; et al. Patients with Systemic Sclerosis Present Increased DNA Damage Differentially Associated with DNA Repair Gene Polymorphisms. JOURNAL OF RHEUMATOLOGY 41:458-465(2014).
    Vignard, J; Mirey, G; et al. Ionizing-radiation induced DNA double-strand breaks: A direct and indirect lighting up. RADIOTHERAPY AND ONCOLOGY 108:362-369(2013).

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