ZIC3

  • Official Full Name

    Zic family member 3

  • Overview

    This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. This nuclear protein probably functions as a transcription factor in early stages of left-right body axis formation. Mutations in this gene cause X-linked visceral heterotaxy, which includes congenital heart disease and left-right axis defects in organs.
  • Synonyms

    ZIC3; Zic family member 3; heterotaxy 1 , HTX1, Zic family member 3 (odd paired homolog, Drosophila); zinc finger protein ZIC 3; HTX; ZNF203; heterotaxy 1; zinc finger protein 203; zinc finger protein of the cerebellum 3; Zic family member 3 (odd-paired;

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ZIC3-165HCL Recombinant Human ZIC3 293 Cell Lysate HEK293 N/A
Human ZIC3-438H Recombinant Human ZIC3 Protein, His-tagged E.coli His
Mouse ZIC3-19178M Recombinant Mouse ZIC3 Protein Mammalian Cell His
Mouse ZIC3-10380M-B Recombinant Mouse ZIC3 Protein Pre-coupled Magnetic Beads HEK293
Mouse ZIC3-10380M Recombinant Mouse ZIC3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish ZIC3-270Z Recombinant Zebrafish ZIC3 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

ZIC3 involved in several pathways and played different roles in them. We selected most pathways ZIC3 participated on our site, such as Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with ZIC3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Signaling pathways regulating pluripotency of stem cellsNEUROG1;SMAD5;HNF1A;PIK3CG;FGFR2;PIK3CB;NRAS;ID2;WNT11

ZIC3 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding, metal ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ZIC3 itself. We selected most functions ZIC3 had, and list some proteins which have the same functions with ZIC3. You can find most of the proteins on our site.

Function Related Protein
RNA polymerase II core promoter proximal region sequence-specific DNA bindingONECUT2;RFX2;OTX1;GMEB2;CLOCK;NFATC3;SRF;HSF1;TFAP2A
metal ion bindingDMRT2;DNAJC21;ZNF333;KLF12;ADI1;NR5A1A;Itgam&Itgb2;KSR1;STK32B
protein bindingHLA-A;HIST1H2BE;E2F7;PKM;KPNA1;RAI2;PRKAA1;TSEN2;HNRNPH1
sequence-specific DNA bindingRORAA;TAF2;PAX7A;PAX2A;SREBF1;HOXA11;WHSC1;ZKSCAN1;BHLHE22
transcription factor activity, sequence-specific DNA bindingSHOX;CSRNP2;FOXP3;ZNF577;NFAT5;GATA2A;TSC22D1;STAT1A;ZFY2
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingOTX2;TTC6;MYOCD;FOXA1;GMEB1;SPI1;NFATC3;FOXI1;MZF1

ZIC3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ZIC3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ZIC3.

TP53; CTNNB1; TWIST1

Research Area

Related articles

Aruga, J; Nozaki, Y; et al. Expression of ZIC family genes in meningiomas and other brain tumors. BMC CANCER 10:-(2010).
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