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ZNF473

Official Full Name

zinc finger protein 473
Overview

Involved in histone 3'-end pre-mRNA processing by associating with U7 snRNP and interacting with SLBP/pre-mRNA complex. Increases histone 3'-end pre-mRNA processing but has no effect on U7 snRNP levels, when overexpressed. Required for cell cycle progression from G1 to S phases.
Synonyms

ZNF473; zinc finger protein 473; ZN473; HZFP100; zfp-100; zinc finger protein ZFP100; zinc finger protein 100 homolog; Zfp 100; ZNF 473; 4932441F21; D030014N22Rik;

Type

Cell & Tissue Lysates
Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rhesus Macaque

Source

E.coli
HEK293
Mammalian Cell

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	ZNF473-2033HCL	Recombinant Human ZNF473 cell lysate		Non		Inquiry
Human	ZNF473-301199H	Recombinant Human ZNF473 protein, GST-tagged	E.coli	GST	Met1-Glu204	Inquiry
Human	ZNF473-582H	Recombinant Human ZNF473 Protein, His-tagged	E.coli	His		Inquiry
Mouse	ZFP473-18953M	Recombinant Mouse ZFP473 Protein	Mammalian Cell	His		Inquiry
Mouse	ZNF473-10429M-B	Recombinant Mouse ZNF473 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	ZNF473-10429M	Recombinant Mouse ZNF473 Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry
Rhesus Macaque	ZNF473-5333R	Recombinant Rhesus monkey ZNF473 Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	ZNF473-5146R	Recombinant Rhesus Macaque ZNF473 Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry
Rhesus Macaque	ZNF473-5146R-B	Recombinant Rhesus Macaque ZNF473 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

ZNF473 involved in several pathways and played different roles in them. We selected most pathways ZNF473 participated on our site, such as Cleavage of Growing Transcript in the Termination Region, Gene Expression, Generic Transcription Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ZNF473 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Cleavage of Growing Transcript in the Termination Region	ZNF473;LSM11;SRSF11;CSTF2;LSM10;THOC4;RNPS1;CLP1;U2AF2
Gene Expression	ZFP90;GTF3AB;ZNF707;ZNF212;POLR3H;ZNF426;ZNF205;ZNF43;JUNB
Generic Transcription Pathway	ZNF461;COX14;RARGA;ZNF23;ZNF613;NR2C2;ZNF114;ZNF189;PSTPIP2
Processing of Capped Intronless Pre-mRNA	LSM11;ZFP473;LSM10;CSTF2;ZNF473;NUDT21;PAPOLA;CSTF3;SLBP
RNA Polymerase II Transcription	THOC4;CSTF3;RNPS1;CCNT2B;ZFP473;SUPT16H;CCNT2A;CLP1;CSTF2
RNA Polymerase II Transcription Termination	RNPS1;LSM10;U2AF2;CSTF3;SLBP;CSTF1;NUDT21;ZFP473;LSM11
SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	ZNF473;LSM10;SLBP;ZFP473;LSM11
SLBP independent Processing of Histone Pre-mRNAs	LSM10;ZNF473;LSM11;ZFP473

ZNF473 has several biochemical functions, for example, DNA binding, metal ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ZNF473 itself. We selected most functions ZNF473 had, and list some proteins which have the same functions with ZNF473. You can find most of the proteins on our site.

Function	Related Protein
DNA binding	MBD3;ARID3C;ZNF670;HES3;ZNF239;NR0B2A;PMS1;BBX;MECP2
metal ion binding	ARSH;ANKMY2A;CYBA;BCL6A;RPS27L;SAP30;COX4I2;SGSH;CYP26C1
protein binding	ERAL1;GYPC;ITGB1BP2;POLL;SCRN2;IPO11;PSMA2;TNFAIP8L2;ING1

ZNF473 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ZNF473 here. Most of them are supplied by our site. Hope this information will be useful for your research of ZNF473.

RNPS1; ZSCAN12; ZNF250; CLK2; KRTAP10-8; KRTAP10-9; ZNF792

Research Area

Hu, C; Zhang, SP; et al. Roles of Kruppel-associated Box (KRAB)-associated Co-repressor KAP1 Ser-473 Phosphorylation in DNA Damage Response. JOURNAL OF BIOLOGICAL CHEMISTRY 287:18937-18952(2012).

White, D; Rafalska-Metcalf, IU; et al. The ATM Substrate KAP1 Controls DNA Repair in Heterochromatin: Regulation by HP1 Proteins and Serine 473/824 Phosphorylation. MOLECULAR CANCER RESEARCH 10:401-414(2012).