Stat5 Protein is an Important Target for the Research of Prostate Cancer
Among many factors that affect prostate cancer, Stat5 is one of the important.
As early as in 2003, scientists have discovered that Stat5 protein is critical for viability of prostate cancer cells and growth of prostate tumors in mice. In 2005, researchers demonstrated that Stat5 activity was associated with recurrence of prostate cancer in patients who had already been treated. Then, in 2008 the researcher showed that nuclear Stat5 was especially prevalent in recurrent prostate cancers that are resistant to hormone therapy. Moreover, researchers found that that blocking Stat5 in laboratory and in animal models effectively destroyed prostate cancer.
Stat5 is a kind of transcription factor, a protein that can regulate expression of other genes. This time, researchers found that the number and level of gene Stat5 is linked to castrate-resistant metastatic prostate cancer cells. In the study, they found that the gene that the protein is amplified.
Based on this, researchers are trying to block or inhibit the Stat5 pathway to treat affected patients. Their assumptions have been entering clinical trials. Stat5 can also be a biomarker that identifies which parts of patients are most likely to respond to Stat5 inhibition.
The finding expands our understanding on Stat5 Protein. But we believe there are still many “unquarried” aspects.
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Article Link: Stat5 Protein is an Important Target for the Research of Prostate CancerTags: Stat5, Prostate Cancer, Hormone