stat5b
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  • Official Full Name
  • Signal Transducer And Activator Of Transcription 5B
  • Background
  • The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL).
  • Synonyms
  • STAT5B; signal transducer and activator of transcription 5B; STAT5; OTTHUMP00000198374; transcription factor STAT5B
Cat.#:STAT5B-2902HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human STAT5B Protein, MYC/DDK-tagged
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Cat.#:STAT5B-1851HTag:His|T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human STAT5B protein, His & T7-tagged
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Cat.#:STAT5B-197HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human STAT5B, His-tagged
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Cat.#:STAT5B-2998HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human STAT5B, GST-tagged
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Cat.#:STAT5B-343HTag:His|MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human STAT5B protein, His/MBP-tagged
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Cat.#:STAT5B-74HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human STAT5B, GST-tagged
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Cat.#:STAT5B-16112MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse STAT5B Protein
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Cat.#:STAT5B-5780RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat STAT5B Protein
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Cat.#:STAT5B-982CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus STAT5B Protein, His-tagged
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Cat.#:STAT5B-6343CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken STAT5B
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Cat.#:STAT5B-1183ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish STAT5B
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Cat.#:STAT5B-1709HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human STAT5B cell lysate
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Involved Pathway

STAT5B involved in several pathways and played different roles in them. We selected most pathways STAT5B participated on our site, such as ErbB signaling pathway, Chemokine signaling pathway, Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with STAT5B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ErbB signaling pathway
CAMK2B1; AKT2L; NRG2; AKT3A; SHC4; PIK3R3; PIK3CB; CAMK2D2; SHC2; EGFRA
Chemokine signaling pathway
CRKL; CCL21; RAC1; SHC4; GNAI3; RHOA; KRAS; CCL3; GM13304; ARRB1
Jak-STAT signaling pathway
GM13305; Il6ra; IL2RB; GRB2; M17; CSF3R; SOCS3B; STAT5A; STAT1A; BCL2
Prolactin signaling pathway
SOCS7; SHC4; CCND1; RAF1; PPIB; CSH; MAP2K2; MAPK10; LHB; SOCS5
Hepatitis B
STAT1; IFNAR1; NFATC2; TGFB3; EGR3; MAPK8; IFNA17; STAT5B; IRF7; CREB5
Measles
IFNGR1; AKT1; RELA; MSN; PIK3CD; IFNB1; TLR9; IRF3; TNFAIP3; STAT5B
HTLV-I infection
FZD3; HLA-DPA1; IL1R2; NFATC1; VCAM1; RAN; NRAS; HLA-DQA1; POLD4; HLA-DMB
Pathways in cancer
WNT10B; AXIN1; AGTR1B; MAP2K2; RUNX1T1; HIF1A; FGF1; WNT3A; FGF22; GNG3
Viral carcinogenesis
ATF4; GTF2H3; GTF2B; TRAF1; GSN; TBPL2; HIST1H2BF; HIST1H4N; ACTN1; REL
Chronic myeloid leukemia
HDAC1; MDM2; RUNX1; ABL1; MAPK3; TGFBR1; PTPN11; PIK3CD; IKBKG; CBLB
Acute myeloid leukemia
TCF7L2; MAPK1; CEBPA; IKBKG; RUNX1T1; PIM2; KRAS; PIK3CD; PML; STAT5A

Protein Function

STAT5B has several biochemical functions, for example, DNA binding, chromatin binding, glucocorticoid receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by STAT5B itself. We selected most functions STAT5B had, and list some proteins which have the same functions with STAT5B. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein RBL2; STRA13; SIM1B; KDM5A; ZFP28; POLE3; TRIM26; MXD4; HMX4; ZBTB9
Function chromatin binding
Related Protein TRP53; FOXN4; KDM5A; SKIL; CHD8; C19orf40; ORC1L; RBMX; ZGLP1; MECP2
Function glucocorticoid receptor binding
Related Protein FKBP4; STAT3; STAT5B; ETS2; EP300; NR4A2; GRIP1; YWHAH; CEBPB; NRIP1
Function protein binding
Related Protein THOC4; KIAA0141; PSMD3; ITGA4; ZFP259; CHERP; ACACA; TTC30B; S1PR3; FCN2
Function protein dimerization activity
Related Protein MEF2B; MYCL1; ASCL5; MYCS; MESP1; MXD4; HER11; DNM1; GARS; TFAP2C
Function signal transducer activity
Related Protein VMN1R46; F2RL2; PLK2; GRM6A; TAAR7F; OLFR476; MAPKAPK2B; STMN1; TMED4; GNG8
Function transcription factor activity, sequence-specific DNA binding
Related Protein ZNF792; RXRGA; MYRFL; TFAM; ATF4B1; SMAD6A; NR2F1B; FOXP1B; BTBD8; FOXD5

Interacting Protein

STAT5B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with STAT5B here. Most of them are supplied by our site. Hope this information will be useful for your research of STAT5B.
NMI; VCAM1; STAP2

STAT5B Related Articles

Zhang, Q; Wang, HY; et al. Cutaneous T Cell Lymphoma Expresses Immunosuppressive CD80 (B7-1) Cell Surface Protein in a STAT5-Dependent Manner. JOURNAL OF IMMUNOLOGY 192:2913-2919(2014).
Atkinson, TP; et al. Immune deficiency and autoimmunity. CURRENT OPINION IN RHEUMATOLOGY 24:515-521(2012).

STAT5B Related Gene Family

Cytokines