Recombinant Human LDLR Protein, Strep-tagged

Cat.No. : LDLR-346H
Product Overview : Recombinant human LDLR protein with Strep tag was expressed in HEK293.
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Description : The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. The encoded protein is normally bound at the cell membrane, where it binds low density lipoprotein/cholesterol and is taken into the cell. Lysosomes release the cholesterol, which is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.
Source : HEK293
Species : Human
Tag : Strep
Form : Lyophilized
Molecular Mass : 87.8 kDa
Protein length : 860
AA Sequence : MGPWGWKLRWTVALLLAAAGTAVGD RCERNEFQCQDGKCISYKWVCDGSA ECQDGSDESQETCLSVTCKSGDFSC GGRVNRCIPQFWRCDGQVDCDNGSD EQGCPPKTCSQDEFRCHDGKCISRQ FVCDSDRDCLDGSDEASCPVLTCGP ASFQCNSSTCIPQLWACDNDPDCED GSDEWPQRCRGLYVFQGDSSPCSAF EFHCLSGECIHSSWRCDGGPDCKDK SDEENCAVATCRPDEFQCSDGNCIH GSRQCDREYDCKDMSDEVGCVNVTL CEGPNKFKCHSGECITLDKVCNMAR DCRDWSDEPIKECGTNECLDNNGGC SHVCNDLKIGYECLCPDGFQLVAQR RCEDIDECQDPDTCSQLCVNLEGGY KCQCEEGFQLDPHTKACKAVGSIAY LFFTNRHEVRKMTLDRSEYTSLIPN LRNVVALDTEVASNRIYWSDLSQRM ICSTQLDRAHGVSSYDTVISRDIQA PDGLAVDWIHSNIYWTDSVLGTVSV ADTKGVKRKTLFRENGSKPRAIVVD PVHGFMYWTDWGTPAKIKKGGLNGV DIYSLVTENIQWPNGITLDLLSGRL YWVDSKLHSISSIDVNGGNRKTILE DEKRLAHPFSLAVFEDKVFWTDIIN EAIFSANRLTGSDVNLLAENLLSPE DMVLFHNLTQPRGVNWCERTTLSNG GCQYLCLPAPQINPHSPKFTCACPD GMLLARDMRSCLTEAEAAVATQETS TVRLKVSSTAVRTQHTTTRPVPDTS RLPGATPGLTTVEIVTMSHQALGDV AGRGNEKKPSSVRALSIVLPIVLLV FLCLGVFLLWKNWRLKNINSINFDN PVYQKTTEDEVHICHNQDGYSYPSR QMVSLEDDVA
Purity : > 98%
Applications : WB; ELISA; FACS; FC
Stability : This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use.
Storage : At -20 centigrade.
Concentration : 1 mg/mL
Storage Buffer : PBS (pH 7.4-7.5). Sterile-filtered colorless solution.
Reconstitution : Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance.
Gene Name : LDLR low density lipoprotein receptor [ Homo sapiens (human) ]
Official Symbol : LDLR
Synonyms : LDLR; low density lipoprotein receptor; low-density lipoprotein receptor; familial hypercholesterolemia; LDL receptor; low-density lipoprotein receptor class A domain-containing protein 3; FH; FHC; LDLCQ2;
Gene ID : 3949
mRNA Refseq : NM_000527
Protein Refseq : NP_000518
MIM : 606945
UniProt ID : P01130

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Customer Reviews (3)

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Reviews
08/11/2020

    The LDLR protein stands out for its exceptional quality, making it an excellent choice to meet my experimental requirements.

    10/07/2018

      Its purity and consistency guarantee reliable and reproducible results, ensuring the reliability of my research outcomes.

      03/04/2017

        the LDLR protein offers superior quality and reliability, making it a perfect fit for my experimental needs.

        Q&As (5)

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        Are there conditions where upregulation of LDLR might be beneficial? 03/17/2022

        Yes, conditions where increasing the expression or function of LDLR could potentially aid in reducing circulating LDL cholesterol and minimizing cardiovascular risk.

        Are there ongoing research efforts regarding LDLR and its clinical applications? 09/02/2021

        Yes, research is continually conducted to better understand LDLR-related conditions and to develop more effective treatments, including gene-editing technologies and novel therapies.

        What are the clinical implications of LDLR dysfunction? 09/01/2020

        Dysfunction in LDLR can lead to high levels of LDL cholesterol in the blood, contributing to conditions like familial hypercholesterolemia and an increased risk of heart disease.

        How does LDLR impact atherosclerosis? 05/27/2020

        A dysfunctional LDLR can lead to an accumulation of LDL cholesterol in the arteries, promoting atherosclerosis, the hardening and narrowing of arteries.

        What treatment options exist for LDLR-related conditions? 02/23/2018

        Treatments involve lifestyle changes, cholesterol-lowering medications, and in some cases, gene therapies or specialized medications targeting the LDL receptor.

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