Recombinant Human LDLR Protein, Strep-tagged

• Cat.No.: LDLR-346H
• Product Overview: Recombinant human LDLR protein with Strep tag was expressed in HEK293.

Specification

• Description: The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. The encoded protein is normally bound at the cell membrane, where it binds low density lipoprotein/cholesterol and is taken into the cell. Lysosomes release the cholesterol, which is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.
• Source: HEK293
• Species: Human
• Tag: Strep
• Form: Lyophilized
• Molecular Mass: 87.8 kDa
• Protein length: 860
• AA Sequence: MGPWGWKLRWTVALLLAAAGTAVGD RCERNEFQCQDGKCISYKWVCDGSA ECQDGSDESQETCLSVTCKSGDFSC GGRVNRCIPQFWRCDGQVDCDNGSD EQGCPPKTCSQDEFRCHDGKCISRQ FVCDSDRDCLDGSDEASCPVLTCGP ASFQCNSSTCIPQLWACDNDPDCED GSDEWPQRCRGLYVFQGDSSPCSAF EFHCLSGECIHSSWRCDGGPDCKDK SDEENCAVATCRPDEFQCSDGNCIH GSRQCDREYDCKDMSDEVGCVNVTL CEGPNKFKCHSGECITLDKVCNMAR DCRDWSDEPIKECGTNECLDNNGGC SHVCNDLKIGYECLCPDGFQLVAQR RCEDIDECQDPDTCSQLCVNLEGGY KCQCEEGFQLDPHTKACKAVGSIAY LFFTNRHEVRKMTLDRSEYTSLIPN LRNVVALDTEVASNRIYWSDLSQRM ICSTQLDRAHGVSSYDTVISRDIQA PDGLAVDWIHSNIYWTDSVLGTVSV ADTKGVKRKTLFRENGSKPRAIVVD PVHGFMYWTDWGTPAKIKKGGLNGV DIYSLVTENIQWPNGITLDLLSGRL YWVDSKLHSISSIDVNGGNRKTILE DEKRLAHPFSLAVFEDKVFWTDIIN EAIFSANRLTGSDVNLLAENLLSPE DMVLFHNLTQPRGVNWCERTTLSNG GCQYLCLPAPQINPHSPKFTCACPD GMLLARDMRSCLTEAEAAVATQETS TVRLKVSSTAVRTQHTTTRPVPDTS RLPGATPGLTTVEIVTMSHQALGDV AGRGNEKKPSSVRALSIVLPIVLLV FLCLGVFLLWKNWRLKNINSINFDN PVYQKTTEDEVHICHNQDGYSYPSR QMVSLEDDVA
• Purity: > 98%
• Applications: WB; ELISA; FACS; FC
• Stability: This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use.
• Storage: At -20 centigrade.
• Concentration: 1 mg/mL
• Storage Buffer: PBS (pH 7.4-7.5). Sterile-filtered colorless solution.
• Reconstitution: Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance.

Gene Information

• Gene Name: LDLR low density lipoprotein receptor [ Homo sapiens (human) ]
• Official Symbol: LDLR
• Synonyms: LDLR; low density lipoprotein receptor; low-density lipoprotein receptor; familial hypercholesterolemia; LDL receptor; low-density lipoprotein receptor class A domain-containing protein 3; FH; FHC; LDLCQ2
• Gene ID: 3949
• mRNA Refseq: NM_000527
• Protein Refseq: NP_000518
• MIM: 606945
• UniProt ID: P01130

Reviews

08/11/2020

The LDLR protein stands out for its exceptional quality, making it an excellent choice to meet my experimental requirements.

10/07/2018

Its purity and consistency guarantee reliable and reproducible results, ensuring the reliability of my research outcomes.

03/04/2017

the LDLR protein offers superior quality and reliability, making it a perfect fit for my experimental needs.

Q&As

Are there conditions where upregulation of LDLR might be beneficial?

Yes, conditions where increasing the expression or function of LDLR could potentially aid in reducing circulating LDL cholesterol and minimizing cardiovascular risk.

Are there ongoing research efforts regarding LDLR and its clinical applications?

Yes, research is continually conducted to better understand LDLR-related conditions and to develop more effective treatments, including gene-editing technologies and novel therapies.

What are the clinical implications of LDLR dysfunction?

Dysfunction in LDLR can lead to high levels of LDL cholesterol in the blood, contributing to conditions like familial hypercholesterolemia and an increased risk of heart disease.

How does LDLR impact atherosclerosis?

A dysfunctional LDLR can lead to an accumulation of LDL cholesterol in the arteries, promoting atherosclerosis, the hardening and narrowing of arteries.

What treatment options exist for LDLR-related conditions?

Treatments involve lifestyle changes, cholesterol-lowering medications, and in some cases, gene therapies or specialized medications targeting the LDL receptor.