LDLR
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Official Full Name
low density lipoprotein receptor
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Overview
The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants. -
Synonyms
LDLR; FH; FHC; LDLCQ2; low density lipoprotein receptor; low-density lipoprotein receptor; LDL receptor; low-density lipoprotein receptor class A domain-containing protein 3; sLOX-1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Native Proteins
- Protein Pre-coupled Magnetic Beads
- Antibody
- Ala22-Arg788
- Bos taurus (Bovine)
- Chicken
- Cynomolgus
- Cynomolgus monkey
- Human
- Mouse
- Rabbit
- Rat
- Rhesus Macaque
- C-His-Avi
- E.coli
- E.coli expression system
- HEK293
- HEK293T
- Human Cell
- Human plasma
- Mammalian Cell
- Mammalian cells
- Rabbit
- Wheat Germ
- Fc
- Flag
- GST
- His
- Avi
- T7
- mFc
- Myc
- DDK
- Non
- Strep
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
LDLR involved in several pathways and played different roles in them. We selected most pathways LDLR participated on our site, such as Endocytosis, Ovarian steroidogenesis, Aldosterone synthesis and secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with LDLR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Endocytosis | VPS26BL;IQSEC3;ARAP1;CAPZA1B;MET;CLINT1A;ITCHA;VPS28;GRK7B |
| Ovarian steroidogenesis | INS;AKR1C3;ALOX5;FSHR;IGF1;INSR;ACOT2;LDLR;HSD3B4 |
| Aldosterone synthesis and secretion | NETO2;PRKACG;ATF1;AKR1C1;PLCB4;CAMK1D;CREB3;ATF2;CREB3L2 |
| Bile secretion | BAAT;SLC22A7;PRKACG;ABCC3;SLC4A4;AQP9;KCNN2;ABCG2;SLCO1B3 |
| Toxoplasmosis | ALOX5;CD40LG;MAPK13;Toxoplasma Gondii Microneme Protein MIC3;TGFB1;MYD88;MAPK12;BCL2L1;MAP3K7 |
| Hepatitis C | PIK3R1;NFKB1;IFNA7;PIK3CG;OAS1B;IKBKG;CLDN11;EIF2AK3;STAT3 |
LDLR has several biochemical functions, for example, calcium ion binding, clathrin heavy chain binding, glycoprotein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LDLR itself. We selected most functions LDLR had, and list some proteins which have the same functions with LDLR. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium ion binding | FSTL1;CD248;FBLN7;SWAP70;SYT11;F9A;PCDH15A;ANXA5B;PSPH |
| clathrin heavy chain binding | CLTA;PICALM;KIAA1199;LDLR;GPR107;CLTB |
| glycoprotein binding | SELP;BMPR1B;FBXO6;RGMA;STX1A;FBXO17;CD4;APOH;LRRK2 |
| low-density lipoprotein particle binding | CDH13;THBS1;COLEC12;SORL1;SCARF1;LIPC;LDLR;ANKRA2;MSR1 |
| low-density lipoprotein receptor activity | VLDLR;CXCL16;LRP12;LDLR;LRP6;OLR1 |
| protease binding | CFLAR;ALPI;ITGAV;CCDC71L;ANXA2;OS9;ADAM8A;CST3;FAP |
| protein binding | HSPG2;GBF1;ALDOC;PRKD2;ALK;THOC5;ATRX;SH3GLB1;STX7 |
| receptor activity | ADIPOR1B;KIR2DL3;PAQR9;PVRL1A;CADM4;SLC20A1;PROCR;MCC;LILRA3 |
| very-low-density lipoprotein particle receptor activity | APOBR;LDLR;VLDLR |
| virus receptor activity | CD209A;TYRO3;HLA-DRB1;TNFRSF4;AXL;ITGB1;SELPLG;CXCR4;RPSA |
LDLR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LDLR here. Most of them are supplied by our site. Hope this information will be useful for your research of LDLR.
PCSK9; APOE; APOB; env; FLT1
Research Area
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Customer Reviews (3)
Write a reviewThe LDLR protein stands out for its exceptional quality, making it an excellent choice to meet my experimental requirements.
Its purity and consistency guarantee reliable and reproducible results, ensuring the reliability of my research outcomes.
the LDLR protein offers superior quality and reliability, making it a perfect fit for my experimental needs.
Q&As (5)
Ask a questionYes, conditions where increasing the expression or function of LDLR could potentially aid in reducing circulating LDL cholesterol and minimizing cardiovascular risk.
Yes, research is continually conducted to better understand LDLR-related conditions and to develop more effective treatments, including gene-editing technologies and novel therapies.
Dysfunction in LDLR can lead to high levels of LDL cholesterol in the blood, contributing to conditions like familial hypercholesterolemia and an increased risk of heart disease.
A dysfunctional LDLR can lead to an accumulation of LDL cholesterol in the arteries, promoting atherosclerosis, the hardening and narrowing of arteries.
Treatments involve lifestyle changes, cholesterol-lowering medications, and in some cases, gene therapies or specialized medications targeting the LDL receptor.
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