| Description : |
The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. The encoded protein is normally bound at the cell membrane, where it binds low density lipoprotein/cholesterol and is taken into the cell. Lysosomes release the cholesterol, which is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants. |
| Source : |
HEK293 |
| Species : |
Cynomolgus monkey |
| Tag : |
His |
| Form : |
Lyophilized |
| Molecular Mass : |
86.8 kDa |
| Protein Length : |
860 |
| AA Sequence : |
MEPWGWKLRWTVAFLLAAAEAAVGD RCERNEFQCEDGKCISYKWVCDGTA ECQDGSDESQETCLSVTCKSGDFSC GGRVNRCIPQFWRCDGEVDCENGSD EQDCPPKTCSQDEFRCHDGKCIYRQ FVCDSDRDCLDGSDEASCPVLTCGP ASFQCNSSTCIPQLWACDNDPDCED GSDEWPQHCQGLEVPKRDSSPCSAF EFHCRSGECIHSGWRCDGGPDCKDK SDEENCPVATCRPDEFQCSDGTCIH GSRQCDREYDCKDMSDEVGCINVTL CEGPNKFKCHSGECISLDKVCNMAR DCRDWSDEPIKECGTNECLDNNGGC SHICNDLKIGYECLCPDGFQLVAQR RCEDIDECQDPDTCSQLCVNLEGSY KCQCEEGFQLDPHTKACKAVGSIAY LIFTNRHEVRKMTLDRSEYTSLIPN LRNVVALDTEVASNRIYWSDLSQRM IYSTQLDRAHSVSSYDTVISRDLQA PDGLAVDWIHSNIYWTDSVLGTVSV ADTKGVKRKTLFRENGSKPRAIVVD PVHGFMYWTDWGTPAKIKKGGLNGV DIYSLVTENIEWPNGITLDFPSGRL YWVDSKLHSISSIDVNGGNRKTVLE DKERLAHPFSLAIFEDKVFWTDIIN EAIFSANRLTGSDINLLAENLLSPE DMVLFHNLTQPRGVNWCERTTLSNG GCQYLCLPAPQINPQSPKFTCTCPD GMLLAKDMRSCLTEAEAAVATQETS TVRLMVSSKAVATQHTTTRPVPNTS QLPGATPGLTTAETVTMSHQALGDV AGRGNEKKPKSVGALSIVLPTVLLV FLCLGAFLLWKNWRLKSINSINFDN PVYQKTTEDEVHICRNQDGYSYPSR QMVSLEDDVA |
| Purity : |
> 98% |
| Applications : |
WB; ELISA; FACS; FC |
| Stability : |
This bioreagent is stable at 4 centigrade (short-term) and -70 centigrade(long-term). After reconstitution, sample may be stored at 4 centigrade for 2-7 days and below -18 centigrade for future use. |
| Storage : |
At -20 centigrade. |
| Concentration : |
1 mg/mL |
| Storage Buffer : |
PBS (pH 7.4-7.5). Sterile-filtered colorless solution. |
| Reconstitution : |
Reconstitute in sterile distilled H2O to no less than 100 μg/mL; dilute reconstituted stock further in other aqueous solutions if needed. Please review COA for lot-specific instructions. Final measurements should be determined by the end-user for optimal performance. |
