BMP Modulator
Available Resources for BMP Modulator Research
Creative BioMart provides a diverse range of products related to BMP modulators, such as recombinant proteins, protein pre-coupled magnetic beads, and cell and tissue lysates. We also offer customized services to meet your specific needs and ensure you receive the product you require.
Our resources go beyond just products and services. We offer a plethora of information on BMP modulators, covering pathways, protein function, interacting proteins, related articles, research areas, and other relevant topics. These resources are invaluable for researchers looking to enhance their understanding of BMP modulators and their role in physiological processes.
Our Featured Products
| Cat.# | Product name | Species | Source (Host) | Tag |
|---|---|---|---|---|
| CER1-11121H | Recombinant Human CER1, GST-tagged | Human | E.coli | GST |
| CER1-3331H | Recombinant Human CER1 protein, His-tagged | Human | E.coli | His |
| CHRDL1-11202H | Recombinant Human CHRDL1, GST-tagged | Human | E.coli | GST |
| Chrdl1-297M | Recombinant Mouse Chrdl1 Protein, His-tagged | Mouse | E.coli | His |
| NBL1-682HB | Active Recombinant Human NBL1, His tagged, Biotinylated | Human | HEK293 | His |
| NOG-817H | Recombinant Human NOG, Fc tagged | Human | Human Cell | Fc |
| NOG-1323H | Recombinant Human NOG, His-tagged | Human | E.coli | His |
| SOST-2880H | Recombinant Human SOST, His-tagged | Human | E.coli | His |
| Sost-3326R | Recombinant Rat Sost, His tagged | Rat | Human Cell | His |
| TSKU-3450H | Recombinant Human TSKU, GST-tagged | Human | E.coli | GST |
About BMP Modulator
BMP (Bone Morphogenetic Protein) modulators are proteins that regulate the activity and signaling of BMPs, which are a subgroup of the transforming growth factor-beta (TGF-β) superfamily. BMPs are involved in a wide range of biological processes, including embryonic development, tissue homeostasis, and the formation and regeneration of bone and other tissues.
BMP modulators play critical roles in controlling the activity and function of BMPs by either enhancing or inhibiting their signaling pathways. These modulators help fine-tune the BMP signaling cascade, ensuring proper development and maintaining tissue integrity.
There are several types of BMP modulators, each with distinct mechanisms of action. Here are some examples:
BMP Antagonists
These modulators, such as noggin, chordin, and gremlin, bind to BMPs and prevent their interaction with BMP receptors. By blocking BMP-receptor binding, antagonists inhibit BMP signaling, leading to suppression of downstream signaling pathways. This inhibition is crucial for maintaining the balance of BMP activity during embryonic development and tissue homeostasis.
BMP Agonists
Certain proteins, such as BMP-2 and BMP-7, act as BMP agonists. They bind to BMP receptors and promote BMP signaling, leading to the activation of downstream pathways. These agonists play important roles in processes like bone formation, regeneration, and tissue repair.
Co-receptors and Co-factors
BMP modulators also include co-receptors and co-factors that enhance or inhibit BMP signaling. For instance, the type III BMP receptor, also known as betaglycan, acts as a co-receptor and enhances the binding of BMPs to their type II receptors, thereby increasing BMP signaling. Other co-factors, such as twisted gastrulation (Tsg) and crossveinless (Cv) proteins, can either promote or inhibit BMP signaling depending on the context.
The balance between BMP agonists, antagonists, and co-factors is crucial for regulating BMP signaling and ensuring proper cellular responses. Dysregulation of BMP modulators can lead to developmental abnormalities, skeletal disorders, and other diseases.
In summary, BMP modulators are proteins that control the activity and signaling of BMPs, a subgroup of the TGF-β superfamily. These modulators, including antagonists, agonists, co-receptors, and co-factors, fine-tune the BMP signaling cascade, playing critical roles in embryonic development, tissue homeostasis, and various physiological processes. Understanding the functions and interactions of BMP modulators is essential for unraveling the complex regulatory mechanisms underlying BMP signaling and its implications in health and disease.
Research and Development of BMP Modulators
The research and development of BMP modulators involve various aspects, including understanding the mechanisms of BMP signaling, developing new modulators, optimizing their properties, and exploring their potential applications. Here are some key areas of research and development related to BMP modulators:
- Mechanisms of BMP Signaling: Researchers aim to elucidate the complex signaling pathways and mechanisms underlying BMP signaling. This involves studying the interactions of BMP ligands, receptors, and downstream signaling molecules. Understanding these mechanisms helps identify potential targets for modulating BMP signaling and designing effective modulators.
- Identification and Characterization of Modulators: Researchers strive to identify and characterize novel BMP modulators. This can involve screening natural compounds, synthetic molecules, or biologics to identify substances that can enhance or inhibit BMP signaling. Through in vitro and in vivo studies, researchers evaluate the effects of these modulators on BMP activity, cellular responses, and tissue regeneration.
- Structural Studies: Structural studies of BMP ligands, receptors, and modulators provide valuable insights into their interactions and binding mechanisms. Techniques such as X-ray crystallography, nuclear magnetic resonance (NMR), and cryo-electron microscopy (cryo-EM) help determine the three-dimensional structures of these molecules, facilitating the rational design of modulators with improved binding affinity and specificity.
- Optimization of Modulator Properties: Researchers work on optimizing the properties of BMP modulators to enhance their therapeutic potential. This includes improving their stability, pharmacokinetics, and bioavailability. Efforts are made to develop modulators with longer half-lives, increased selectivity, and reduced immunogenicity to enhance their clinical efficacy and safety.
- Delivery Systems: Developing effective delivery systems for BMP modulators is an active area of research. Researchers explore various approaches, including nanoparticles, hydrogels, gene delivery vectors, and sustained-release systems, to achieve controlled and localized delivery of BMP modulators. These delivery systems aim to improve the therapeutic outcomes, reduce off-target effects, and enhance the regenerative capacity of BMP modulators.
Continued research in this field holds promise for developing more effective and targeted therapies for various diseases and disorders.
If you have any questions, requirements, or cooperation intentions, please feel free to contact us. We very much look forward to working with you and helping you achieve research and commercial success.
References:
- Heinke J, Kerber M, Rahner S, et al. Bone morphogenetic protein modulator BMPER is highly expressed in malignant tumors and controls invasive cell behavior. Oncogene. 2012 Jun;31(24):2919-2930. DOI: 10.1038/onc.2011.473. PMID: 22020334; PMCID: PMC3376172.
- Esser J S, Steiner R E, Deckler M, et al. Extracellular bone morphogenetic protein modulator BMPER and twisted gastrulation homolog 1 preserve arterial‐venous specification in zebrafish blood vessel development and regulate Notch signaling in endothelial cells[J]. The FEBS Journal, 2018, 285(8): 1419-1436.
