NOG

  • Official Full Name

    noggin

  • Overview

    The secreted polypeptide, encoded by this gene, binds and inactivates members of the transforming growth factor-beta (TGF-beta) superfamily signaling proteins, such as bone morphogenetic protein-4 (BMP4). By diffusing through extracellular matrices more efficiently than members of the TGF-beta superfamily, this protein may have a principal role in creating morphogenic gradients. The protein appears to have pleiotropic effect, both early in development as well as in later stages. It was originally isolated from Xenopus based on its ability to restore normal dorsal-ventral body axis in embryos that had been artificially ventralized by UV treatment. The results of the mouse knockout of the ortholog suggest that it is involved in numerous developmental processes, such as neural tube fusion and joint formation. Recently, several dominant human NOG mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) were identified; both SYM1 and SYNS1 have multiple joint fusion as their principal feature, and map to the same region (17q22) as this gene. All of these mutations altered evolutionarily conserved amino acid residues. The amino acid sequence of this human gene is highly homologous to that of Xenopus, rat and mouse.
  • Synonyms

    NOG; noggin; SYM1; SYNS1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • GMP Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Dog
  • Human
  • Mouse
  • Mouse/Rat
  • Pig
  • Rat
  • Rhesus Macaque
  • CHO
  • CHO-K1
  • E. coli
  • E.coli
  • HEK293
  • Human Cell
  • Human cells
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Nicotiana Benthamiana
  • NS0
  • Wheat Germ
  • C
  • Fc
  • hFc
  • His
  • GST
  • His (Fc)
  • Avi
  • His|GST
  • His|MBP
  • Myc
  • human|IgG1|Fc
  • N/A
  • N
  • Strep II
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human NOG-2745H Active Recombinant Human Noggin Nicotiana Benthamiana N/A
Human NOG-204H Active Recombinant Human NOG protein HEK293 N/A
Human NOG-01HG Active GMP Recombinant Human NOG Protein CHO-K1
Human NOG-817H Recombinant Human NOG, Fc tagged Human Cell Fc
Human NOG-223H Recombinant Human NOG, StrepII-tagged Human Cell Strep II
Human NOG-046H Recombinant Human NOG protein, Fc-tagged HEK293 human/IgG1/Fc
Human NOG-3156H Active Recombinant Human NOG protein(Met1-Cys232), His-tagged HEK293 C-His
Human NOG-30336TH Recombinant Human NOG E.coli N/A
Human NOG-1323H Recombinant Human NOG, His-tagged E.coli His
Human NOG-30339TH Recombinant Human NOG N/A
Human NOG-21H Recombinant Human NOG protein E.coli N/A
Human NOG-454H Recombinant Human Noggin HEK293 N/A
Human NOG-2414HCL Recombinant Human NOG cell lysate Human Cell N/A
Human NOG-213N Active Recombinant Human NOG Protein CHO
Human NOG-117HG Active GMP Recombinant Human NOG Protein Mammalian cells Fc
Human NOG-27H Recombinant Human NOG Protein E.coli
Human NOG-5966H Recombinant Human NOG Protein, GST-tagged Wheat Germ GST
Human NOG-120HG Active GMP Recombinant Human NOG Protein Mammalian cells N/A
Human NOG-6681HF Recombinant Full Length Human NOG Protein, GST-tagged In Vitro Cell Free System GST
Human NOG-29H Active Recombinant Human NOG Protein, Pre-aliquoted NS0
Human NOG-42H Active Recombinant Human NOG Protein, Animal Free Human cells
Human NOG-293H Recombinant Human NOG protein Insect Cell N/A
Human NOG-066N Active Recombinant Human NOG Protein (206 aa) E.coli
Human NOG-1423H Recombinant Human NOG protein, His-GST & Myc-tagged E.coli His-GST & Myc
Human NOG-126H Recombinant Human NOG Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human NOG-001H Active Recombinant Human NOG Protein HEK293
Human NOG-03HG Active Recombinant Human NOG Protein (Gln28-Cys232), C-Fc-tagged, GMP Grade NS0 C-Fc
Human NOG-119HG Active GMP Recombinant Human NOG protein HEK293
Human NOG-401H Recombinant Human NOG Protein, Fc-tagged HEK293 Fc
Human NOG-126H-B Recombinant Human NOG Protein Pre-coupled Magnetic Beads HEK293
Human NOG-3367H Recombinant Human NOG Protein (Gln28-Cys232), His tagged E.coli His
Human NOG-315H Active Recombinant Human NOG Protein (Gln28-Cys232), C-Fc tagged, Animal-free, Carrier-free HEK293 C-Fc
Human NOG-321H Recombinant Human NOG Protein, His-tagged E.coli His
Mouse NOG-887M Active Recombinant Mouse NOG protein(Met1-Cys232), hFc-tagged HEK293 C-hFc
Mouse Nog-954M Recombinant Mouse Nog protein E.coli N/A
Mouse Nog-1770M Recombinant Mouse Noggin Mammalian cells N/A
Mouse Nog-10603M Recombinant Mouse Nog Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Nog-10603M-B Recombinant Mouse Nog Protein Pre-coupled Magnetic Beads HEK293
Mouse Nog-322M Recombinant Mouse Nog Protein, His/GST-tagged E.coli His/GST
Mouse Nog-4452M Active Recombinant Mouse Nog Protein E. coli
Mouse Nog-019N Active Recombinant Mouse Nog Protein (206 aa) E.coli
Mouse Nog-212N Active Recombinant Mouse Nog Protein CHO
Rat Nog-590R Recombinant Rat Nog protein, His & MBP-tagged E.coli His/MBP
Rat Nog-324R Recombinant Rat Nog Protein, His/GST-tagged E.coli His/GST
Rat Nog-1834R Recombinant Rat Nog Protein, His&GST-tagged E.coli N-His&GST
Rat Nog-325R Recombinant Rat Nog Protein, His/MBP-tagged E.coli His/MBP
Dog NOG-319D Recombinant Dog NOG Protein, His-tagged E.coli His
Mouse/Rat Nog-28M Recombinant Mouse/Rat Nog Protein E.coli
Rhesus Macaque NOG-3062R Recombinant Rhesus monkey NOG Protein, His-tagged Mammalian Cell His
Rhesus Macaque NOG-2881R Recombinant Rhesus Macaque NOG Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque NOG-2881R-B Recombinant Rhesus Macaque NOG Protein Pre-coupled Magnetic Beads HEK293
Pig NOG323P Recombinant Pig NOG Protein, His-tagged E.coli His
Chicken NOG-5699C Recombinant Chicken NOG Mammalian Cell His
Chicken NOG-320C Recombinant Chicken NOG Protein, His-tagged E.coli His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • NOG Related Articles
  • NOG Related Research Area

NOG involved in several pathways and played different roles in them. We selected most pathways NOG participated on our site, such as BMP receptor signaling, BMP signalling and regulation, Cardiac Progenitor Differentiation, which may be useful for your reference. Also, other proteins which involved in the same pathway with NOG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
BMP receptor signalingHFE2;CALML4;RGMA;SKI;CTDSP1;NOG;CTDSPL;AHSG;CTDSP2
BMP signalling and regulationTOB1;NOG
Cardiac Progenitor DifferentiationBMP1;NIPAL1;LIN28B;IRX4;SIRPA;TBX5;ZFP42;T;NKX2
Signal TransductionRGS20;ARHGEF1A;ARHGAP29B;DISP2;MKS1;ARHGAP17B;OPN4B;AXL;ARHGEF3
Signaling by BMPSKIA;FSTL1A;CALML4;CHRDL1;FSTL1B;NOG1;FSTL1;GREM2;NOG
TGF Beta Signaling PathwayTGFBR3;ZFP423;FST;FOXH1;LEFTY1;ZNF423;RUNX3;ENG;NOG
TGF-beta signaling pathwayLFT2;GDF5;ID1;ACVR1B;LEFTY2;IFNG1-2;INHBC;BMP7;ACVR1

NOG has several biochemical functions, for example, cytokine binding, protein binding, protein complex binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NOG itself. We selected most functions NOG had, and list some proteins which have the same functions with NOG. You can find most of the proteins on our site.

Function Related Protein
cytokine bindingNRP2;KIT;CRLF1;CXCR4;CNTFR;IL17F;GBP1;IFNGR1;TNFRSF11A
protein bindingCSPG5;GDNF;FAM58A;TCAP;DRD3;VIL1;SOX9;ADRA2B;GALNT3
protein complex bindingSH2B3;RANBP2;CDK5RAP1;ADRB2;TWF1;VPS28;SHANK1;CALY;NFYB
protein homodimerization activityANXA1;TFAP4;LDB1;ZFP365;PVRL2;AMBP;CLN6;MVD;SNX2

NOG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NOG here. Most of them are supplied by our site. Hope this information will be useful for your research of NOG.

BMP2; BMP7; GDF5

Ohshima, S; Mori, S; et al. Differentiation ability of multipotent hematopoietic stem/progenitor cells detected by a porcine specific anti-CD117 monoclonal antibody. BIOSCIENCE TRENDS 8:308-315(2014).
Ishikawa, Y; Usui, T; et al. Functional engraftment of human peripheral T and B cells and sustained production of autoantibodies in NOD/LtSzscid/IL-2R gamma(-/-) mice. EUROPEAN JOURNAL OF IMMUNOLOGY 44:3453-3463(2014).
  • Q&As
  • Reviews

Q&As (7)

Ask a question
How does NOG (Noggin) modulate bone morphogenetic protein (BMP) signaling in development and tissue repair? 10/25/2022

NOG inhibits BMP signaling, critical for tissue development and repair processes.

What are the mechanisms by which NOG modulates embryonic patterning and organogenesis? 09/05/2021

NOG modulates embryonic patterning and organogenesis, guiding proper organ development.

How do alterations in NOG expression or function affect the development of congenital anomalies? 02/08/2020

Changes in NOG expression or function can lead to congenital anomalies due to disrupted developmental processes.

How does NOG contribute to the regulation of stem cell differentiation? 07/11/2019

NOG regulates stem cell differentiation, influencing their development into various tissue types.

What role does NOG play in skeletal development and the regulation of bone growth? 02/11/2019

NOG plays a key role in skeletal development by regulating bone growth and differentiation.

How does NOG influence neural development and neurogenesis? 02/03/2019

NOG influences neural development, impacting the formation and specialization of neural cells.

What is the impact of NOG in joint and cartilage health, particularly in arthritis? 01/07/2018

NOG is important for joint and cartilage health, potentially impacting arthritis progression.

Customer Reviews (3)

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Reviews
07/15/2022

    Efficient peptide synthesis, accelerates our peptide research projects.

    04/30/2018

      Fast and reliable protein expression, aids our experiments significantly.

      01/25/2018

        Dependable antibody validation, crucial for our immunoprecipitation studies.

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