sost
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  • Official Full Name
  • sclerostin
  • Background
  • Canonical Wnt-signalling plays an important role in the regulation of bone homeostasis by promoting the development of osteoblasts. Negative regulators of the Wnt pathway are important new therapeutic targets for the treatment of diseases with enhanced bone resorption. One of these molecules is Sclerostin, a 22.5 kD secreted glycoprotein, which acts by binding to the Wnt-coreceptor LRP5 thus preventing the binding of Wnt molecules. Sclerostin is nearly exclusively produced in osteocytes. Therefore it is considered a clinical marker which provides highest bone specificity.
  • Synonyms
  • SOST; sclerostin; CDD; VBCH; sclerosteosis; Blosozumab; 1132758-87-2; Romosozumab; 909395-70-6
Cat.#:SOST-403HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human SOST Protein (Gln24-Tyr213), His-tagged, Biotinylated
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Cat.#:SOST-270HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human SOST, His-tagged, Biotinylated
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Cat.#:SOST-2880HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SOST, His-tagged
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Cat.#:SOST-8121HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SOST protein, His & GST-tagged
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Cat.#:SOST-870HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human SOST, His tagged
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Cat.#:SOST-925HTag:His
Source (Host):NS0Species:Human
Product nameRecombinant Human SOST, His-tagged
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Cat.#:Sost-753MTag:His
Source (Host):NSO CellsSpecies:Mouse
Product nameRecombinant Mouse Sost Protein, His-tagged
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Cat.#:Sost-8122MTag:His/GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Sost protein, His & GST-tagged
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Cat.#:Sost-3326RTag:His
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat Sost, His tagged
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Cat.#:SOST-5673RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat SOST Protein
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Cat.#:SOST-4410RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey SOST Protein, His-tagged
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Cat.#:SOST-2846HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human SOST cell lysate
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Cat.#:SOST-2251RCLTag:
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat SOST cell lysate
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Involved Pathway

SOST involved in several pathways and played different roles in them. We selected most pathways SOST participated on our site, such as Wnt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SOST were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Wnt signaling pathway
NFATC3; RHOAB; GSK3B; DAAM2; DKK4; PLCB1; WNT1; TRP53; FZD6; BAMBI

Protein Function

SOST has several biochemical functions, for example, heparin binding, protein binding, transcription factor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SOST itself. We selected most functions SOST had, and list some proteins which have the same functions with SOST. You can find most of the proteins on our site.
Function
Related Protein
Function heparin binding
Related Protein POSTN; LXN; VEGFA; VEGFAA; BMP7; GPNMB; SMOC2; ANG; NDNF; FBLN7
Function protein binding
Related Protein HGD; RBCK1; TAF7; KCND2; SSR1; CWC15; GATA5; NIPA2; ZNF567; SPERT
Function transcription factor binding
Related Protein NR0B2A; IFI203; TRIB2; NKX2-1; NAAA; NLRP3; H2-AB1; CRY1; TRIB1; KCTD1

Interacting Protein

SOST has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SOST here. Most of them are supplied by our site. Hope this information will be useful for your research of SOST.
LRP4; LRP5; LRP6; Ca1; Jph1; Tnik; bt3l4_rat_protein

SOST Related Articles

Recker, RR; Benson, CT; et al. A Randomized, Double-Blind Phase 2 Clinical Trial of Blosozumab, a Sclerostin Antibody, in Postmenopausal Women with Low Bone Mineral Density. JOURNAL OF BONE AND MINERAL RESEARCH 30:216-224(2015).
Gerbaix, M; Vico, L; et al. Periostin expression contributes to cortical bone loss during unloading. BONE 71:94-100(2015).