aatk
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  • Official Full Name
  • apoptosis-associated tyrosine kinase
  • Background
  • The protein encoded by this gene contains a tyrosine kinase domain at the N-terminus and a proline-rich domain at the C-terminus. This gene is induced during apoptosis, and expression of this gene may be a necessary pre-requisite for the induction of growth arrest and/or apoptosis of myeloid precursor cells. This gene has been shown to produce neuronal differentiation in a neuroblastoma cell line. Two transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • AATK; apoptosis-associated tyrosine kinase; serine/threonine-protein kinase LMTK1; AATYK; AATYK1; KIAA0641; lemur tyrosine kinase 1; LMR1; LMTK1; p35-binding protein; CDK5-binding protein; brain apoptosis-associated tyrosine kinase; p35BP
Cat.#:AATK-029HTag:GST
Source (Host):Wheat Germ (in vitro)Species:Human
Product nameRecombinant Human AATK Protein, GST-tagged
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Cat.#:AATK-645HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human AATK Protein, His-tagged
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Cat.#:AATK-3037HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Mouse
Product nameRecombinant house mouse AATK, GST-tagged
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Cat.#:Aatk-646MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Aatk Protein, His-tagged
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Cat.#:AATK-6993MTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Mouse
Product nameRecombinant Mouse AATK, GST-tagged
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Protein Function

AATK has several biochemical functions, for example, ATP binding, kinase activity, nucleotide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AATK itself. We selected most functions AATK had, and list some proteins which have the same functions with AATK. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein UBE2J2; ADRBK1; STK32A; EIF4A3; ATP2B1B; TTLL11; DDX47; FGFR1; NEK11; SCYL1
Function kinase activity
Related Protein GM7168; GRK7A; NEK1; MAP2K4A; GSK3B; KDRL; BSK146; JAK2B; ROCK2A; SPS2
Function nucleotide binding
Related Protein SMG1; DHX32A; NSFA; RBM44; SNRNP200; SEPT5B; MTHFSD; HNRNPM; TLK1A; HNRNPA2B1
Function protein binding
Related Protein MAB21L2; TNNI1; BLOC1S2; PAN2; C1QA; AKAP7; GPAA1; PLXNC1; PRKG1; Icosl
Function protein kinase activity
Related Protein TEX14; MAPK14A; EGFRA; NRBP2; BMPR2B; PIK3CG; ARAF; CAMK2D1; EPHB4B; RPS6KA6
Function protein serine/threonine kinase activity
Related Protein MAP4K4; MLKL; PLK4; MAST4; SMG1; BMPR1BA; PRKCD; OXSR1B; MAPK4; ROCK2A
Function protein tyrosine kinase activity
Related Protein JAK2B; LYN; HCK; SRMS; MATK; MET; TNK1; BTK; MAP2K2; FGR
Function transferase activity
Related Protein PKM; TSSK5; STK30; CAMK1DA; MAP3K4; CKMT2A; ZDHHC5A; ELOVL7; SMYD1B; GM7168

AATK Related Articles

Ling, YH; Lin, RP; et al. Erlotinib induces mitochondrial-mediated apoptosis in human H3255 non-small-cell lung cancer cells with epidermal growth factor receptor(L858R) mutation through mitochondrial oxidative phosphorylation-dependent activation of BAX and BAK. MOLECULAR PHARMACOLOGY 74:793-806(2008).
Nishioka, C; Ikezoe, T; et al. Ki11502, a novel multitargeted receptor tyrosine kinase inhibitor, induces growth arrest and apoptosis of human leukemia cells in vitro and in vivo. BLOOD 111:5086-5092(2008).