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AATK

Official Full Name

apoptosis-associated tyrosine kinase
Overview

The protein encoded by this gene contains a tyrosine kinase domain at the N-terminus and a proline-rich domain at the C-terminus. This gene is induced during apoptosis, and expression of this gene may be a necessary pre-requisite for the induction of growth arrest and/or apoptosis of myeloid precursor cells. This gene has been shown to produce neuronal differentiation in a neuroblastoma cell line. Two transcript variants encoding different isoforms have been found for this gene.
Synonyms

AATK; apoptosis-associated tyrosine kinase; serine/threonine-protein kinase LMTK1; AATYK; AATYK1; KIAA0641; lemur tyrosine kinase 1; LMR1; LMTK1; p35-binding protein; CDK5-binding protein; brain apoptosis-associated tyrosine kinase; p35BP;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	AATK-029H	Recombinant Human AATK Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	AATK-645H	Recombinant Human AATK Protein, His-tagged	E.coli	His	Leu1216~Ala1374	Inquiry
Mouse	Aatk-646M	Recombinant Mouse Aatk Protein, His-tagged	E.coli	His	Tyr137~Gln386	Inquiry
Mouse	AATK-6993M	Recombinant Mouse AATK, GST-tagged	Sf9 Insect Cell	GST	8-411 aa	Inquiry
Mouse	AATK-3037H	Recombinant house mouse AATK, GST-tagged	Sf9 Insect Cell	GST	5706	Inquiry

Involved Pathway
Protein Function
Interacting Protein
AATK Related Articles

AATK involved in several pathways and played different roles in them. We selected most pathways AATK participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with AATK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

AATK has several biochemical functions, for example, ATP binding, kinase activity, nucleotide binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AATK itself. We selected most functions AATK had, and list some proteins which have the same functions with AATK. You can find most of the proteins on our site.

Function	Related Protein
ATP binding	KCNJ11;TRIB3;TNNI3K;GSK3AB;KIF19;GARS;MAP3K6;BMX;FLAD1
kinase activity	MTOR;NTRK3A;PDXK;SMOK2B;EPHB3A;FYNB;TSSK5;PKZ;MAP2K4A
nucleotide binding	PCXB;PTBP1;RBM19;EPHB4A;GNAO1A;CCC2;RND1L;RBPMS;TRNAU1AP
protein binding	MAGI1;CKS1B;TANK;MPHOSPH8;NDUFS2;C21orf7;TMPRSS7;S100A13;DNMT3A
protein kinase activity	CAMKK1B;OXSR1A;RPS6KB1;MINK1;RPS6KB2;CAMK2B1;DCLK1A;STK25B;CHUK
protein serine/threonine kinase activity	ROCK2B;CIT;SYK;CLK3;VPRBP;STK33;TP53RK;ILK;MAP3K14
protein tyrosine kinase activity	KITA;ALK;DYRK1B;TYK2;TNK1;SRMS;MAP2K5;BCR;Fert2
transferase activity	MAPK8A;UGT2B1;FYNB;MAPK12B;MGAT4C;PRKCBP1L;UGT5C3;MCAT;SULT1ST1

AATK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AATK here. Most of them are supplied by our site. Hope this information will be useful for your research of AATK.

Ling, YH; Lin, RP; et al. Erlotinib induces mitochondrial-mediated apoptosis in human H3255 non-small-cell lung cancer cells with epidermal growth factor receptor(L858R) mutation through mitochondrial oxidative phosphorylation-dependent activation of BAX and BAK. MOLECULAR PHARMACOLOGY 74:793-806(2008).

Nishioka, C; Ikezoe, T; et al. Ki11502, a novel multitargeted receptor tyrosine kinase inhibitor, induces growth arrest and apoptosis of human leukemia cells in vitro and in vivo. BLOOD 111:5086-5092(2008).