ABCA1 Protein, ATP-binding cassette, sub-family A (ABC1), member 1


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Official Full Name ATP-binding cassette, sub-family A (ABC1), member 1
Background The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. In humans, this protein functions as a cholesterol efflux pump in the cellular lipid removal pathway. Mutations in the human gene have been associated with Tangiers disease and familial high-density lipoprotein deficiency.
Synonyms ABCA1; ATP-binding cassette, sub-family A (ABC1), member 1; ABC1, HDLDT1; ATP-binding cassette sub-family A member 1; Tangier disease; TGD; membrane-bound; ATP-binding cassette transporter 1; ATP-binding cassette transporter A1; cholesterol efflux regulat
    • Species :
    • Chicken
    • Human
    • Mouse
    • Source :
    • E.coli
    • E.Coli or Yeast
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ABCA1-178H Recombinant Human ABCA1 protein, GST-tagged Wheat Germ GST
    Human ABCA1-459H Recombinant Human ABCA1 Mammalian Cell His
    Human ABCA1-5857H Recombinant Human ABCA1 protein, His-tagged E.coli His
    Mouse ABCA1-3696M Recombinant Mouse ABCA1, His-tagged E.coli His
    Mouse Abca1-3728M Recombinant Mouse Abca1, His-tagged E.Coli or Yeast His
    Chicken ABCA1-5721C Recombinant Chicken ABCA1 Mammalian Cell His

    ABCA1 involved in several pathways and played different roles in them. We selected most pathways ABCA1 participated on our site, such as ABC transporters, Fat digestion and absorption, Fatty acid, triacylglycerol, and ketone body metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ABCA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    ABC transporters ABCD2; ABCA9; ABCB1A; ABCG2; ABCC11; ABCC3; ABCB7; ABCC6; TAP2; CFTR
    Fat digestion and absorption FABP2; PLA2G10; PPAP2C; PLA2G3; ACAT2; PNLIPRP2; PLA2G2A; LIPF; ABCG8; MOGAT2
    Fatty acid, triacylglycerol, and ketone body metabolism PLIN2; ESRRA; APOA5; CYP4A11; ACOT10; ECI1; ACOT8; ACOT13; ACOT2; MED16
    Folate Metabolism SAA4; SAA1; AHCY; ABCA1; SAA2; SAA2-SAA4
    HDL-mediated lipid transport Alb; AMN; BMP1A; APOC2; APOA1B; ABCA1; CETP
    Lipid digestion, mobilization, and transport APOA1B; FABP9; APOF; CLPS; APOEB; LMF1; FABP11B; MTP; APOEA; Alb
    Lipoprotein metabolism ABCA1; APOEA; APOBB.1; APOA5; APOEB; APOA4B.1; MTP; APOA1B; APOA4B.2; APOC2
    Metabolism MED31; CYP4T8; AK8; ARSD; CKMT2; ABHD10; ATP5S; MED20; DECR1; PDK3

    ABCA1 has several biochemical functions, for example, ATP binding, ATPase activity, coupled to transmembrane movement of substances, ATPase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ABCA1 itself. We selected most functions ABCA1 had, and list some proteins which have the same functions with ABCA1. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding MCM9; PDK3; PIK3CA; EP400; EPHB3A; RAF1; NLRP9C; DYRK2; ACSL1; cka1
    ATPase activity, coupled to transmembrane movement of substances ABCA1B; IPO8; ABCA7; ABCB8; ABCD3; ABCC5; ABCA1; ABCA9; ABCD4; DPY19L2
    anion transmembrane transporter activity SLC4A1A; SLC26A11; SLC4A4A; ABCA1; SLC4A2A; SLC4A2B; SLC4A8; SLC4A11; Slc4a2; SLC4A1
    apolipoprotein A-I binding ABCA1; SCARB1; LCAT; ABCA1B
    apolipoprotein A-I receptor activity ABCA1; ABCA7
    apolipoprotein binding LPA; PCSK9; MAPT; LRP6; PLG; VLDLR; LIPC; ABCA1; SCARB1; LRP1
    cholesterol binding CETP; ABCG1; APOC3; APOEA; OSBPL7; APOA2; SCP2; CYP11A1; ABCA1; SYP
    cholesterol transporter activity ABCA4A; ABCA7; ABCA1; STAR; APOA4A; ABCG1; APOA1A; APOA1; ABCA1B; APOA4B.1
    phospholipid binding SYT14; DAPP1; NBEA; APOEB; APOC3; NBEAL2; NBEAA; SPTB; PACSIN1; SNCA
    phospholipid transporter activity ABCG1; ABCA13; ABCA4A; MFSD2AB; MFSD2AA; ATP8B5; MFSD2A; OSBPL5; ABCA1; OSBPL8
    protein binding MFAP1; TRIM10; SSX2IP; CTBP2; NVL; MAPK11; NBR1; SRA1; DYNLL1; MX1
    receptor binding WNT2BA; CD58; HFE2; EDA; IFNL3; CRTAM; TNFSF10; VTCN1; APP; PDGFRB
    small GTPase binding FGD4; FLNA; FGD1; TSC2; FGD2; PEX5L; RNF152; ABCA1; FGD5; FGD6
    syntaxin binding SYTL3; SYT1A; SYT11B; TMED10; SYT12; CXorf15; CPLX2L; STX10; CPLX4A; SYT9B

    ABCA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ABCA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ABCA1.


    Nicod, N; Parker, RS; et al. Isomer-specific effects of conjugated linoleic acid on HDL functionality associated with reverse cholesterol transport. JOURNAL OF NUTRITIONAL BIOCHEMISTRY 26:165-172(2015).
    Tomkin, GH; Owens, D; et al. Investigational therapies for the treatment of atherosclerosis. EXPERT OPINION ON INVESTIGATIONAL DRUGS 23:1411-1421(2014).

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