ABCA1
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Official Full Name
ATP-binding cassette, sub-family A (ABC1), member 1 -
Overview
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. In humans, this protein functions as a cholesterol efflux pump in the cellular lipid removal pathway. Mutations in the human gene have been associated with Tangiers disease and familial high-density lipoprotein deficiency. -
Synonyms
ABCA1;ATP-binding cassette, sub-family A (ABC1), member 1;ABC1, HDLDT1;ATP-binding cassette sub-family A member 1;Tangier disease;TGD;membrane-bound;ATP-binding cassette transporter 1;ATP-binding cassette transporter A1;cholesterol efflux regulat
Recombinant Proteins
- Human
- Mouse
- Chicken
- Wheat Germ
- E.coli
- E.Coli/Yeast
- Mammalian Cells
- HEK293
- GST
- His
- Avi
- Fc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| ABCA1-178H | Recombinant Human ABCA1 protein, GST-tagged | Wheat Germ | Human | GST | 86-185 a.a. |
|
| ABCA1-3696M | Recombinant Mouse ABCA1, His-tagged | E.coli | Mouse | His | 2261 |
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| Abca1-3728M | Recombinant Mouse Abca1, His-tagged | E.Coli/Yeast | Mouse | His | 2261 |
|
| ABCA1-459H | Recombinant Human ABCA1 | Mammalian Cells | Human | His |
|
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| ABCA1-5721C | Recombinant Chicken ABCA1 | Mammalian Cells | Chicken | His |
|
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| ABCA1-5857H | Recombinant Human ABCA1 protein, His-tagged | E.coli | Human | His | Asn1385~Phe1663 |
|
| ABCA1-0185H | Recombinant Human ABCA1 Protein (Ser45-Glu271), N-His-tagged | E.coli | Human | His | Ser45-Glu271 |
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| ABCA1-10H | Recombinant Human ABCA1 Protein, His-tagged | E.coli | Human | His | Arg43-Glu450 |
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| ABCA1-2398H | Recombinant Human ABCA1 Protein, His (Fc)-Avi-tagged | HEK293 | Human | Avi&Fc&His |
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| ABCA1-2398H-B | Recombinant Human ABCA1 Protein Pre-coupled Magnetic Beads | HEK293 | Human |
|
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| ABCA1-2493H | Recombinant Human ABCA1 protein(1171-1280 aa), C-His-tagged | E.coli | Human | His | 1171-1280 aa |
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| ABCA1-3141H | Recombinant Human ABCA1 protein, His-tagged | E.coli | Human | His | 92-272 aa |
|
Involved Pathway
ABCA1 involved in several pathways and played different roles in them. We selected most pathways ABCA1 participated on our site, such as ABC transporters,Fat digestion and absorption,Fatty acid, triacylglycerol, and ketone body metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with ABCA1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| ABC transporters | ABCD3,ABCG1,ABCD1,ABCB3L1,ABCA7,ABCB5,ABCC11,Abcb1b,ABCB6,ABCB1 |
| Metabolism | SYT5,CYP2R1,SLC25A12,DAO1,MOCOS,SLC25A21,AWAT1,APOC2,SLC25A27,PPM1L |
| Fat digestion and absorption | FABP2,PLA2G2F,PNLIP,AGPAT1,PLA2G2D,APOA4,ABCG8,CD36,MTTP,CLPS |
| Lipoprotein metabolism | APOA4A,APOC2,CETP,APOF,APOBB.1,APOA4B.2,APOA5,APOA4B.1,LPA,APOA1B |
| HDL-mediated lipid transport | APOA1B,BMP1A,CETP,AMN,Alb,APOC2 |
| Lipid digestion, mobilization, and transport | APOBB.1,FABP11A,APOF,APOA4A,APOA4B.1,APOC2,CLPS,APOEB,FABP11B,MTP |
| Fatty acid, triacylglycerol, and ketone body metabolism | ACAD11,HELZ2,G0S2,MED20,MED18,TIAM2,CPT2,ACSF3,DGAT1B,ACSF2 |
| Folate Metabolism | AHCY,SAA4,SAA2,SAA1,SAA2-SAA4 |
Protein Function
ABCA1 has several biochemical functions, for example, ATP binding,ATPase activity, coupled to transmembrane movement of substances,ATPase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ABCA1 itself. We selected most functions ABCA1 had, and list some proteins which have the same functions with ABCA1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| apolipoprotein A-I binding | SCARB1,ABCA1B,LCAT |
| protein binding | DNAJB4,SF3B3,IL5RA,TMEM67,OIT3,FOS,cgr2b,NME2,GNAI2,PPAP2B |
| apolipoprotein A-I receptor activity | ABCA7 |
| receptor binding | TNFSF13,ICOSLG,CSK,IDH1,NTF7,PLAT,TNFSF14,CRH,FGF18A,PEX14 |
| ATPase activity, coupled to transmembrane movement of substances | ABCB4,ABCB3L1,ABCC1,ABCG5,ABCC3,ABCG2,ABCC10,ABCA8,ABCA7,ABCC8 |
| phospholipid binding | ANXA5,GRK5,AMPH,ANXA1,BAIAP2L2,OTC,ARHGAP26,PON1,DGKA,SGIP1 |
| cholesterol binding | OSBPL3,SOAT1,APOA1A,CYP11A1,NR1H3,ANXA6,APOA1,APOC3,ABCG1,PROM2 |
| small GTPase binding | RCC2,PEX5L,PEX5,FGD4,FLNA,ERRFI1,FGD6,FGD2,GDI2,TSC2 |
| phospholipid transporter activity | ABCA4A,ABCA13,MFSD2AB,ABCA4,GLTPD1,MTTP,APOA1,OSBPL5,ABCA7,ABCA1B |
Interacting Protein
ABCA1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ABCA1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ABCA1.
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References
- Tomkin, GH; Owens, D; et al. Investigational therapies for the treatment of atherosclerosis. EXPERT OPINION ON INVESTIGATIONAL DRUGS 23:1411-1421(2014).
- Nicod, N; Parker, RS; et al. Isomer-specific effects of conjugated linoleic acid on HDL functionality associated with reverse cholesterol transport. JOURNAL OF NUTRITIONAL BIOCHEMISTRY 26:165-172(2015).
