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ACCN2

  • Official Full Name

    amiloride-sensitive cation channel 2, neuronal

  • Overview

    This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene is expressed in most if not all brain neurons, and it may be an ion channel subunit; however, its function as an ion channel remains unknown. Alternative splicing of this gene generates 2 transcript products.
  • Synonyms

    ACCN2; amiloride-sensitive cation channel 2, neuronal; ASIC1; BNaC2; hBNaC2; neuronal; ACCN2_HUMAN; Acid sensing ion channel 1; Acid sensing ion channel 1a protein; Acid sensing ion channel; Acid-sensing ion channel 1; AI843610; Amiloride sensitive cation channel 2 neuronal; Amiloride-sensitive cation channel 2; ASIC; ASIC1A; B530003N02Rik; Brain sodium channel 2; Cation channel amiloride sensitive neuronal 2; ACCN2 variant 3; acid-sensing ion channel 1a protein; Cation channel, amiloride-sensitive, neuronal, 2;

  • Recombinant Proteins
  • Antibody
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Rhesus Macaque
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ACCN2-04HF Recombinant Full Length Human ACCN2 Protein In Vitro Cell Free System 528 amino acids
Human ACCN2-26289TH Recombinant Human ACCN2 Wheat Germ N/A 528 amino acids
Rhesus Macaque ACCN2-204R Recombinant Rhesus monkey ACCN2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque ACCN2-33R Recombinant Rhesus Macaque ACCN2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque ACCN2-33R-B Recombinant Rhesus Macaque ACCN2 Protein Pre-coupled Magnetic Beads HEK293
Chicken ACCN2-3416C Recombinant Chicken ACCN2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ACCN2 Related Articles

ACCN2 involved in several pathways and played different roles in them. We selected most pathways ACCN2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ACCN2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

ACCN2 has several biochemical functions, for example, acid-sensing ion channel activity, ion gated channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ACCN2 itself. We selected most functions ACCN2 had, and list some proteins which have the same functions with ACCN2. You can find most of the proteins on our site.

Function Related Protein
acid-sensing ion channel activityASIC1B;ASIC1C;ACCN2;ASIC1A;ASIC1
ion gated channel activityACCN2;ASIC1

ACCN2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACCN2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACCN2.

Sun, X; Zhao, D; et al. Regulation of ASIC1 by Ca2+/calmodulin-dependent protein kinase II in human glioblastoma multiforme. ONCOLOGY REPORTS 30:2852-2858(2013).
Mata, X; Ducasse, A; et al. Genomic structure, polymorphism and expression of ACCN1 and ACCN3 genes in the horse. ANIMAL GENETICS 41:138-144(2010).
  • Q&As
  • Reviews

Q&As (10)

Ask a question
What is the recommended concentration of the recombinant ACCN2 protein for my experimental application? 10/10/2022

It varies depending on the specific experimental application. You can seek technical support from our experts for guidance on the appropriate protein concentration for your desired assay or study.

What applications have been validated for the recombinant ACCN2 protein? 09/15/2022

Common applications may include biochemical assays, protein-protein interaction studies, functional studies, or as an antigen for antibody development.

Do you offer technical support or assistance for experimental design or troubleshooting? 08/12/2022

Yes, we have a team of technical experts who can help.

Do you have primary antibodies for ACCN2? 09/03/2021

No, but please feel free to submit any specific requirements, and our team of experts will reach out to you accordingly.

Is it possible to request customized recombinant ACCN2 proteins incorporating potential hotspot mutations? 08/02/2021

Certainly, you have the option to provide detailed information about the mutation site in the online form, and our team of scientists will customize the appropriate protein products exclusively for your needs.

Could you please provide information on the endotoxin level testing method used for recombinant ACCN2 protein? 06/18/2021

The endotoxin level of our recombinant protein is assessed through the widely employed Limulus amebocyte lysate (LAL) assay. When filling out the inquiry form, you have the option to specify the desired endotoxin levels for the recombinant ACCN2 protein.

Our high-purity recombinant proteins are ideal for various biophysics-related research purposes, including structural elucidation, molecular dynamics simulations, and interaction studies. 09/18/2020

Our high-purity recombinant proteins is ideal for various biophysics-related research purposes, including structural elucidation, molecular dynamics simulations, and interaction studies.

What is the tissue distribution pattern of ACCN2? 08/12/2020

ACCN2 is widely expressed in the central nervous system, particularly in regions associated with sensory perception and pain processing, such as the dorsal root ganglia, trigeminal ganglia, and spinal cord. It is also found in other tissues like the heart, lungs, gastrointestinal tract, and kidney.

What is the functional role of ACCN2 in the nervous system? 09/11/2019

ACCN2 has been implicated in neuronal processes, including synaptic transmission, pain perception, and modulation of neuronal excitability. It is involved in acid-induced currents in sensory neurons, contributing to the detection and transmission of acidic stimuli.

How do you ensure the activity and quality of Recombinant ACCN2 Protein? 07/31/2016

We employ rigorous quality control measures to ensure the activity and quality of recombinant protein products. These measures may include functional assays to assess the protein's ability to perform its intended biological function. Additionally, analytical techniques such as SDS-PAGE and mass spectrometry are used to verify the protein's identity and confirm its integrity.

Customer Reviews (3)

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Reviews
05/13/2023

    The high purity of Creative BioMart's recombinant ACCN2 protein made it ideal for my downstream applications.

    11/30/2022

      I am glad I chose the recombinant ACCN2 protein from Creative BioMart. It met all my research needs and was of excellent quality.

      12/01/2018

        The recombinant protein product was well-packaged and delivered promptly. I had a great experience purchasing from Creative BioMart.

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