ACCN4
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Official Full Name
amiloride-sensitive cation channel 4, pituitary
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Overview
This gene belongs to the superfamily of acid-sensing ion channels, which are proton-gated, amiloride-sensitive sodium channels. These channels have been implicated in synaptic transmission, pain perception as well as mechanoperception. This gene is predominantly expressed in the pituitary gland, and was considered a candidate for paroxysmal dystonic choreoathetosis (PDC), a movement disorder, however, no correlation was found between mutations in this gene and PDC. Alternative splicing at this locus results in two transcript variants encoding different isoforms. -
Synonyms
ACCN4; amiloride-sensitive cation channel 4, pituitary; amiloride-sensitive cation channel 4; ASIC4; BNAC4; pituitary; ACCN4_HUMAN; Acid sensing ion channel 4; Acid-sensing ion channel 4; Amiloride sensitive cation channel 4; Brain sodium channel 4;
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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| Mouse | ACCN4-1177M | Recombinant Mouse ACCN4 Protein | Mammalian Cell | His |
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| Mouse | ACCN4-247M-B | Recombinant Mouse ACCN4 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Mouse | ACCN4-247M | Recombinant Mouse ACCN4 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Mouse | Accn4-30M | Recombinant Mouse Accn4 Protein, His-tagged | E.coli | N-His | Pro372-Cys539 |
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- Involved Pathway
- Protein Function
- Interacting Protein
- ACCN4 Related Articles
ACCN4 involved in several pathways and played different roles in them. We selected most pathways ACCN4 participated on our site, such as Inflammatory mediator regulation of TRP channels, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACCN4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Inflammatory mediator regulation of TRP channels | PIK3CB;ASIC1;ACCN3;PIK3CD;CYP4A12A;PRKACA;PRKCH;CAMK2B;ACCN4 |
ACCN4 has several biochemical functions, for example, sodium channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ACCN4 itself. We selected most functions ACCN4 had, and list some proteins which have the same functions with ACCN4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| sodium channel activity | SCN12AB;SCN4AA;ASIC1C;SCN12AA;SCN1LAB;ASIC4;SCN11A;ACCN5;ASIC4A |
ACCN4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACCN4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ACCN4.
- Q&As
- Reviews
Q&As (10)
Ask a questionCreative BioMart offers customization or modification services for recombinant ACCN4 protein, such as adding tags or modifying the protein sequence.
For a limited duration, we have an exclusive holiday promotion where all our products are available with a 10% discount. Time is running out, so make sure to seize this opportunity and benefit from our discounted prices!
Yes, it can be used for various functional assays and protein-protein interaction studies. It is important to verify the suitability of the protein for specific assays and consult the literature or our technical support experts for recommended protocols or experimental conditions.
ACCN4 has been implicated in several pathological conditions, including ischemic brain injury, neurodegenerative diseases, epilepsy, and chronic pain. Dysregulation of ACCN4 activity and expression levels may contribute to neuronal damage and hyperexcitability associated with these disorders. Thus, ACCN4 represents a potential therapeutic target for the development of novel treatments.
It is predominantly localized to the plasma membrane of neurons, including those in the central and peripheral nervous systems. It exhibits a wide tissue distribution, with high expression levels observed in the brain, spinal cord, sensory ganglia, and certain regions of the cardiovascular and gastrointestinal systems.
Depending on the expression system and purification method employed, the occurrence or non-occurrence of post-translational modifications in recombinant ACCN4 protein may differ. We offer tailored manufacturing of recombinant proteins, and you can specify your precise research needs when completing the online inquiry form.
For every product listed on our website, Creative BioMart provides a bulk quotation. To obtain specific pricing details, kindly reach out to our sales representatives.
The His tag enhances protein solubility and is employed for affinity purification, potentially influencing protein activity. If you have concerns about the tag's impact on protein activity, Creative BioMart also offers personalized tag-free ACCN4 protein services.
The pricing of our products varies depending on the specific item. Typically, factors such as purity, quantity, and functional activity contribute to the determination of the price. To obtain information about pricing for specific products, please fill out an inquiry form, or feel free to reach out to our technical support team for consultation.
The recommended concentration and dilution of Recombinant ACCN4 Protein can vary depending on the specific experimental setup and applications. You can check the literature or seek technical support from our experts for recommended starting concentrations and provided protocols or guidelines.
Customer Reviews (3)
Write a reviewThe Recombinant Mouse ACCN4 Protein was exactly what I needed for my experiments. It was easy to handle and produced consistent results.
The Recombinant Mouse ACCN4 Protein was affordable and easy to order. The customer service team was helpful and responsive.
I was impressed with the quality and purity of the recombinant ACCN4 protein. It performed exceptionally well in my experiments.
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