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ADAM33

  • Official Full Name

    ADAM metallopeptidase domain 33

  • Overview

    ADAM13 was first described as a protein expressed in somatic mesoderm and neural crest cells, in developing Xenopus embryos. ADAM13 was also found in liver, heart, and intestines from adult Xenopus. ADAM13 may regulate cellular signaling via Src and Src tyrosine kinase. ADAM13 may also act as a cell attachment molecule, by binding integrins through the cysteine rich domain amoung many other roles. A member of the metalloproteinase family containing disintegrin like domains (ADAMs) the functions of ADAM13 are still poorly understood. ADAM13 contains the canonical HExxHxxxxxH zinc metalloproteinase motif, as well as disintegrin, cysteine rich, EFG like, transmembrane and Cytoplasmic domains. ADAM13 has been shown to be proteolytically active, cleaving fibronectin after binding it to the EGF like domain. ADAM13 is also shed from cells in culture, cleaved aminoterminal from the transmembrane domain, and is released into the culture media. Shed ADAM13 is a 52 kD protein, and can form complexes with a2 macroglobulin, suggesting it is a competent protease. Xenopus ADAM13 has greatest homology with human ADAM 33 (51% identical), and is 46% identical with human or mouse ADAM12 or ADAM19. It is still unclear if any of these ADAMs are species orthologs of Xenopus ADAM13, but there are significant differences between the related sequences, suggesting that ADAM13 may be a unique protein. The full length Xenopus ADAM13 sequence codes for a 914 amino acid protein. Predicted mass is 99.749 kD, but glycosylation and cyteine rich regions give Xenopus ADAM13 an apparent MW of 120 kD unprocessed, and 97 kD processed forms, on reduced SDS PAGE gels. ADAM13 contains a putative furin cleavage site, suggesting that a prohormone convertase cleaves the propeptide domain away from the catalytic domain.
  • Synonyms

    adam13; ADAM metallopeptidase domain 33; x-adam 13; a disintegrin and metalloprotease domain 13;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Chicken
  • Human
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His|T7
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ADAM33-289H Recombinant Human ADAM33 Protein, GST-tagged Wheat Germ GST
Human ADAM33-290H Recombinant Human ADAM33 Protein, GST-tagged Wheat Germ GST
Human ADAM33-9033HCL Recombinant Human ADAM33 293 Cell Lysate HEK293 N/A
Human ADAM33-887HF Recombinant Full Length Human ADAM33 Protein, GST-tagged In Vitro Cell Free System GST 85 amino acids
Human ADAM33-1484H Recombinant Human ADAM33 protein, His & T7-tagged E.coli His/T7 Lys210~Asp503 (Accession # Q9BZ11)
Chicken ADAM33-3673C Recombinant Chicken ADAM33 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ADAM33 Related Articles

ADAM33 involved in several pathways and played different roles in them. We selected most pathways ADAM33 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ADAM33 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

ADAM33 has several biochemical functions, for example, metalloendopeptidase activity, protein binding, zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADAM33 itself. We selected most functions ADAM33 had, and list some proteins which have the same functions with ADAM33. You can find most of the proteins on our site.

Function Related Protein
metalloendopeptidase activityMMP23B;ADAM9;ADAM7;ADAMTS15;SPG7;ADAMTS18;ADAM2;MMP28;MMP23BB
protein bindingAP2B1;TINAGL1;ALDOA;ATP5G1;MYH7B;PRDX1;DCC;SLAMF1;NUP205
zinc ion bindingMMP25;NR5A1A;C6AST1;PRKCG;PCGF6;SETDB1B;HLTF;ADH1B;TRAF4B

ADAM33 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADAM33 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADAM33.

ATXN7; UBQLN4

Holloway, JW; Laxton, RC; et al. ADAM33 expression in atherosclerotic lesions and relationship of ADAM33 gene variation with atherosclerosis. ATHEROSCLEROSIS 211:224-230(2010).
Erbek, SS; Erinanc, H; et al. Expression of a disintegrin and metalloproteinase 33 protein in nasal polyposis: An immunohistochemical study. AMERICAN JOURNAL OF RHINOLOGY & ALLERGY 24:E79-E82(2010).
  • Q&As
  • Reviews

Q&As (12)

Ask a question
What is the main focus of ADAM33's current research? 12/17/2022

ADAM33 current research focuses on asthma

I want to buy ADAM33 protein for WB, which membrane should I choose? 11/10/2022

You can choose PVDF membrane.

I want to buy ADAM33 for ELISA, which product should I choose? 10/27/2022

The choice will depend on your specific research needs and you can talk directly with our experts.

Does the addition of GST tag have any effect on the function of ADAM33 protein and downstream experiments? 09/05/2022

The large molecular weight of GST tag may affect the protein function and downstream experiments.

What are the functions of ADAM33 protein? 05/12/2022

ADAM33 protein has cell activation, protein hydrolysis and signaling functions

Does ADAM33 bind to transcription factor GATA3? 04/07/2022

Transcription factor GATA3 binds to the core promoter region of the ADAM33 gene

Can the tag location of adam33 be customized according to my requirements? 08/30/2021

Yes, we can customize the protein according to your requirements.

Will customization requirements affect eligibility for the promotion? 12/15/2020

Our current promotion is available for all products and services.

Does the purchased ADAM33 protein have endotoxin? 11/21/2020

Depending on your needs, we offer endotoxin removal services

Can the purity of the protein be adjusted according to my requirements? 08/25/2020

Yes, we can customize proteins with different purity levels according to your specific needs.

Where is ADAM33 expressed in large quantities? 07/06/2020

ADAM33 is abundantly expressed in mesenchymal cells and smooth muscle cells

Which one of His tag or GST tag has less effect on protein activity? 02/20/2020

His tag has a smaller molecular weight and has a smaller effect on protein activity.

Customer Reviews (3)

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Reviews
12/26/2021

    Very professional customer service, fully understanding the needs of the customer and giving professional advice.

    09/14/2021

      The purchased ADAM33 protein is suitable for WB experiments and I am satisfied with the results.

      03/27/2021

        The after-sales service is very thoughtful and helped me solve many technical problems satisfactorily.

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