adamts1
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  • Official Full Name
  • ADAM metallopeptidase with thrombospondin type 1 motif, 1
  • Background
  • This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene contains two disintegrin loops and three C-terminal TS motifs and has anti-angiogenic activity. The expression of this gene may be associated with various inflammatory processes as well as development of cancer cachexia. This gene is likely to be necessary for normal growth, fertility, and organ morphology and function. [provided by RefSeq, Jul 2008]
  • Synonyms
  • ADAMTS1; ADAM metallopeptidase with thrombospondin type 1 motif, 1; C3-C5; METH1; A disintegrin and metalloproteinase with thrombospondin motifs 1; METH-1; ADAM-TS1; ADAMTS-1; ADAM-TS 1; human metalloproteinase with thrombospondin type 1 motifs; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 1;
Cat.#:ADAMTS1-531HTag:His
Source (Host):NS0Species:Human
Product nameRecombinant Human ADAMTS1, His-tagged
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Cat.#:ADAMTS1-105HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ADAMTS1, GST-tagged
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Cat.#:ADAMTS1-2048HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ADAMTS1 protein, His-tagged
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Cat.#:ADAMTS1-295HTag:His
Source (Host):Insect CellSpecies:Human
Product nameRecombinant Human ADAMTS1 Protein, His-tagged
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Cat.#:ADAMTS1-296HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ADAMTS1 Protein, GST-tagged
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Cat.#:ADAMTS1-1307MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ADAMTS1 Protein
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Cat.#:Adamts1-2049MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Adamts1 protein, His-tagged
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Cat.#:Adamts1-2050RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Adamts1 protein, His-tagged
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Cat.#:ADAMTS1-234RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey ADAMTS1 Protein, His-tagged
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Cat.#:ADAMTS1-532HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human ADAMTS1, His-tagged
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Involved Pathway

ADAMTS1 involved in several pathways and played different roles in them. We selected most pathways ADAMTS1 participated on our site, such as Degradation of the extracellular matrix, Endochondral Ossification, Extracellular matrix organization, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADAMTS1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Degradation of the extracellular matrix
CTSL2; COL19A1; COL25A1; MMP15; ADAMTS1; TIMP2A; KLK7; MGC174152; CTSL1; COL9A3
Endochondral Ossification
MMP13; DDR2; NKX3-2; CDKN1C; COL10A1A; ADAMTS4; IFT88; KIF3A; SERPINH1; MGP
Extracellular matrix organization
FMOD; MMP12; CRTAP; LAMB1B; COL15A1B; LEPREL2; PCOLCE; COL19A1; LOXL2; TIMP2
Metabolism of proteins
TIMM17B; NSFB; PAPPAB; CXXC1; RNF2; VBP1; DPH5; SEC16B; NAT8B; IGFBP1A
O-glycosylation of TSR domain-containing proteins
ADAMTS10; ADAMTSL1; ADAMTS3; SSPO; SPON1; SPON2; ADAMTSL3; ADAMTS18; ADAMTSL5; ADAMTS20
O-linked glycosylation
GALNT13; ADAMTS20; ADAMTS15; SPON1B; ADAMTS13; ADAMTS1; GALNTL5; MUCL1; ADAMTS18; C8orf84
Post-translational protein modification
MAN1B1; THSD7A; SCMH1; ST6GALNAC1.2; TRAPPC2; ADAMTS8; TMED2; MUCL1; MPDU1A; ADAMTSL3

Protein Function

ADAMTS1 has several biochemical functions, for example, heparin binding, metalloendopeptidase activity, metallopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ADAMTS1 itself. We selected most functions ADAMTS1 had, and list some proteins which have the same functions with ADAMTS1. You can find most of the proteins on our site.
Function
Related Protein
Function heparin binding
Related Protein SLIT1A; FGF1A; NRP1; ZNF146; NRP1A; CRISPLD2; NAV2; FMODA; CFH; C6orf25
Function metalloendopeptidase activity
Related Protein MMP13; ADAMTS15; ADAMTS8; ADAM32; Adam6; MMP1A; MMP30; PHEX; FAP; MMP14B
Function metallopeptidase activity
Related Protein ADAM18; YME1L1; ADAMTS12; ADAM2; ADAM5; ADAM25; C6AST3; ACY1; PAPPA2; C6AST4
Function zinc ion binding
Related Protein CAR7; MORC2B; DDX41; RNF148; POLE; AJUBA; MARCH11; MYT1LA; PGGT1B; ADAM25

Interacting Protein

ADAMTS1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADAMTS1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADAMTS1.
USP17L24; trpE

ADAMTS1 Related Articles

Foulcer, SJ; Nelson, CM; et al. Determinants of Versican-V1 Proteoglycan Processing by the Metalloproteinase ADAMTS5. JOURNAL OF BIOLOGICAL CHEMISTRY 289:27859-27873(2014).
Dallaglio, K; Bruno, A; et al. Paradoxic effects of metformin on endothelial cells and angiogenesis. CARCINOGENESIS 35:1055-1066(2014).