adrb2
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  • Official Full Name
  • adrenoceptor beta 2, surface
  • Background
  • This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes. [provided by RefSeq, Jul 2008]
  • Synonyms
  • ADRB2; adrenoceptor beta 2, surface; BAR; B2AR; ADRBR; ADRB2R; BETA2AR; beta-2 adrenergic receptor; beta-2 adrenoceptor; beta-2 adrenoreceptor; catecholamine receptor; adrenoceptor beta 2 surface; adrenergic, beta-2-, receptor, surface;
Cat.#:ADRB2-25HTag:
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ADRB2 protein
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Cat.#:ADRB2-26HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ADRB2 protein, GST-tagged
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Cat.#:ADRB2-1386MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ADRB2 Protein
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Cat.#:ADRB2-280CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus ADRB2 Protein, His-tagged
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Cat.#:ADRB2-260RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey ADRB2 Protein, His-tagged
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Cat.#:ADRB2-34HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human ADRB2 cell lysate
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Involved Pathway

ADRB2 involved in several pathways and played different roles in them. We selected most pathways ADRB2 participated on our site, such as Adrenergic signaling in cardiomyocytes, Adrenoceptors, Amine ligand-binding receptors, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADRB2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Adrenergic signaling in cardiomyocytes
CACNG1; PPP2R1A; PPP2R5A; CREB3L3A; CACNA2D1; CALM2; CALM2A; PIK3CB; PPP2R5CB; ADRB2A
Adrenoceptors
ADRB2; ADRa1A; ADRB1; ADRA1B; ADRA2B; ADRB3; ADRA1D; ADRA2C; ADRA2A
Amine ligand-binding receptors
ADRB3; CHRM3; ADRA2B; DRD5; HRH3; CHRM1; ADRA2A; DRD1; ADRA2C; ADRa1A
Arf6 signaling events
IPCEF1; AGTR1; USP6; ADRB2; ADAP1; EPHA2; GULP1; KIF13B; ARAP2; EFNA1
Arf6 trafficking events
DNM2; CTNND1; CTNNA1; EXOC1; SCAMP2; EDNRB; ADRB2; CPE; CLTC; SPAG9
Calcium Regulation in the Cardiac Cell
AKR1C1; GJB5; CASQ2; GJB3; GNG13B; CASQ1B; CHRM5; CASQ1; RGS5A; RGS18
Calcium signaling pathway
PTK2BB; NTSR1; PPIF; DRD1B; PPP3R1; HTR2B; PTAFR; PDE1C; CALML3; PDGFRB
Class A/1 (Rhodopsin-like receptors)
SAA1; LPAR2B; CCL35.2; ADRB2; GPR39; CNR2; GPR65; EDN2; CCR8; PENK

Protein Function

ADRB2 has several biochemical functions, for example, B2 bradykinin receptor binding, G-protein alpha-subunit binding, adenylate cyclase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ADRB2 itself. We selected most functions ADRB2 had, and list some proteins which have the same functions with ADRB2. You can find most of the proteins on our site.
Function
Related Protein
Function B2 bradykinin receptor binding
Related Protein ADRB2
Function G-protein alpha-subunit binding
Related Protein AGTR1A; HTR2B; NUCB1; RIC8A; RGS19; DRD1; RGS14; IGF1R; ADRB2; DRD1A
Function adenylate cyclase binding
Related Protein AKAP6; CHRNA7; CALM3; ADRB2; CALM2; AKAP5; CALM1; ADCYAP1R1; AKAP12
Function beta2-adrenergic receptor activity
Related Protein ADRB2; ADRB2A; ADRB2B
Function dopamine binding
Related Protein DRD2B; DRD1B; DRD3; DRD4; DRD2A; DRD1; DRD2; SLC6A3; TH; DRD5
Function drug binding
Related Protein DRD1; CYP2C9; SLC6A4A; ABP1; P2RX4; SRP54; DRD2; HTR2A; IL2RA; DHFR
Function epinephrine binding
Related Protein ADRB2; ADRB1; ADRB3A; ADRA2A; ADRB3; ADRB2B; ADRB3B; ADRB2A; ADRA2C; ADRA2B
Function ionotropic glutamate receptor binding
Related Protein SHANK2; GNAS; SHANK3; CACNG2; ADRB2; DLG1; NETO1; CANX; DLG1L; FLOT2
Function norepinephrine binding
Related Protein ADRB3B; ADRB2; ADRA2A; ADRB1; ADRB3A
Function potassium channel regulator activity
Related Protein LRRC26; KCNE3; KCNIP3; NEDD4L; KCNAB1; YWHAE; KCNAB3; SGK2; KCNS3; KCNMB1
Function protein binding
Related Protein S100B; FAM59A; PSMB5; SUGT1; RARG; PPIL1; C1orf109; C2orf88; NFASC; MICA
Function protein complex binding
Related Protein PRMT5; PCSK2; FBN1; C8G; SLC27A5; CRTAP; UQCRC1; CRHR1; TUB; PDX1
Function protein homodimerization activity
Related Protein RQCD1; CDSN; GRM6; G6PD; IDH1; TERF2; BCL2L10; ADD2; CRYBA1; GABRR1

Interacting Protein

ADRB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADRB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADRB2.
MAGI3; SRC; SLC9A3R1; ARRB2

ADRB2 Related Articles

Hassan, S; Karpova, Y; et al. A pilot study of blood epinephrine levels and CREB phosphorylation in men undergoing prostate biopsies. INTERNATIONAL UROLOGY AND NEPHROLOGY 46:505-510(2014).
Lantsova, VB; Gerasimov, AS; et al. The Role of ADRB2 in Myasthenia: Genetic and Immunological Factors. BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE 154:351-353(2013).

ADRB2 Related Gene Family

GPCRs