adrbk1
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  • Official Full Name
  • adrenergic, beta, receptor kinase 1
  • Background
  • G-protein-coupled receptor kinase 2 (GRK2), also known as beta-adrenergic receptor kinase 1 (beta-ARK1), is a member of the GRK family, which phosphorylates the activated form of G-protein-coupled receptors (GPCRs) and initiates the desensitization proces
  • Synonyms
  • ADRBK1; adrenergic, beta, receptor kinase 1; beta-adrenergic receptor kinase 1; BARK1; GRK2; beta-ARK-1; G-protein coupled receptor kinase 2; BETA-ARK1; FLJ16718
Cat.#:ADRBK1-357HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Adrenergic, Beta, Receptor Kinase 1, His-tagged
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Cat.#:ADRBK1-152HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human ADRBK1
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Cat.#:ADRBK1-383HTag:GST
Source (Host):Insect CellSpecies:Human
Product nameRecombinant Human ADRBK1 Protein, GST-tagged
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Cat.#:ADRBK1-9445HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ADRBK1, His-tagged
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Cat.#:ADRBK1-978HTag:His/GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human ADRBK1, His & GST tagged
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Cat.#:ADRBK1-546RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat ADRBK1 Protein
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Cat.#:ADRBK1-3006CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken ADRBK1
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Cat.#:ADRBK1-1019HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Adrenergic, Beta, Receptor Kinase 1, GST-tagged
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Cat.#:ADRBK1-625HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human ADRBK1 cell lysate
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Involved Pathway

ADRBK1 involved in several pathways and played different roles in them. We selected most pathways ADRBK1 participated on our site, such as Activation of SMO, CXCR4-mediated signaling events, Ca-dependent events, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADRBK1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Activation of SMO
CSNK1A1; EVC; KIF3A; BOC; ADRBK1; CDON; EVC2; SETD6; IQCE; GAS8
CXCR4-mediated signaling events
DNM1; CSK; ADRBK1; MAPKAP1; JAK2; GNA13; CFL1; ARR3; BLK; PAG1
Ca-dependent events
ADCY7; PRKAR1AA; ADRBK1; ADCY9
CaM pathway
ADRBK1; PRKAR1AA
Calmodulin induced events
PRKAR1AA; ADRBK1
Chemokine signaling pathway
PAK1; GRK4; GSK3A; PIK3R2; RHOA; CCL17; STAT2; CXCR1; CCL20; Adcy4
DAG and IP3 signaling
ADRBK1; PRKAR1AA; AHCYL1
DAP12 interactions
KBTBD7; FRS2B; AGO1; PAQR3A; PHB; TREM1; DAB2IPB; CSF2RA; DUSP2; SPNA2

Protein Function

ADRBK1 has several biochemical functions, for example, ATP binding, Edg-2 lysophosphatidic acid receptor binding, G-protein coupled receptor kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ADRBK1 itself. We selected most functions ADRBK1 had, and list some proteins which have the same functions with ADRBK1. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein NLRX1; DHX8; EPHA2; NEK9; ABCG1; ATP2A3; SLC14A2; MOK; EPHB4; PFKFB4
Function Edg-2 lysophosphatidic acid receptor binding
Related Protein ADRBK1
Function G-protein coupled receptor kinase activity
Related Protein GRK1A; GRK4; GRK7; GRK7A; GRK7B; GRK6; GRK5; GRK1; RLN1; GRK1B
Function alpha-2A adrenergic receptor binding
Related Protein APLP1; UCHL1; ADRBK1; ADRA2C; ADRB1
Function beta-adrenergic receptor kinase activity
Related Protein ADRBK1; GRK6; ADRBK2; GRK5
Function protein binding
Related Protein UBD; PPP1R7; FER; AKT2; HIST1H2BE; NUAK2; PDGFC; FKBP5; STAG2; BRAT1
Function protein kinase activity
Related Protein NIM1; CDK7; TGFBR1; BMPR2B; TRIO; RPS6KA3B; RPS6KB2; CAD; GC2; NPRL2

Interacting Protein

ADRBK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADRBK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADRBK1.
UBC; FPR1; EGFR; HDAC6; GIT1; TUBB; MDM2

ADRBK1 Related Articles

Wex, E; Thaler, E; et al. A Novel Model of IgE-Mediated Passive Pulmonary Anaphylaxis in Rats. PLOS ONE 9:-(2014).
Hartung, JE; Ciszek, BP; et al. beta(2)- and beta(3)-adrenergic receptors drive COMT-dependent pain by increasing production of nitric oxide and cytokines. PAIN 155:1346-1355(2014).

ADRBK1 Related Gene Family

GPCRs