adrbk1
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  • Official Full Name
  • adrenergic, beta, receptor kinase 1
  • Background
  • G-protein-coupled receptor kinase 2 (GRK2), also known as beta-adrenergic receptor kinase 1 (beta-ARK1), is a member of the GRK family, which phosphorylates the activated form of G-protein-coupled receptors (GPCRs) and initiates the desensitization proces
  • Synonyms
  • ADRBK1; adrenergic, beta, receptor kinase 1; beta-adrenergic receptor kinase 1; BARK1; GRK2; beta-ARK-1; G-protein coupled receptor kinase 2; BETA-ARK1; FLJ16718
Cat.#:ADRBK1-357HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Adrenergic, Beta, Receptor Kinase 1, His-tagged
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Cat.#:ADRBK1-152HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human ADRBK1
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Cat.#:ADRBK1-383HTag:GST
Source (Host):Insect CellSpecies:Human
Product nameRecombinant Human ADRBK1 Protein, GST-tagged
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Cat.#:ADRBK1-9445HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ADRBK1, His-tagged
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Cat.#:ADRBK1-978HTag:His/GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human ADRBK1, His & GST tagged
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Cat.#:ADRBK1-546RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat ADRBK1 Protein
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Cat.#:ADRBK1-3006CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken ADRBK1
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Cat.#:ADRBK1-1019HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Adrenergic, Beta, Receptor Kinase 1, GST-tagged
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Cat.#:ADRBK1-625HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human ADRBK1 cell lysate
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Involved Pathway

ADRBK1 involved in several pathways and played different roles in them. We selected most pathways ADRBK1 participated on our site, such as Activation of SMO, CXCR4-mediated signaling events, Ca-dependent events, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADRBK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Activation of SMO
EVC; EVC2; CDON; GAS8; BOC; CSNK1A1; SETD6; IQCE; KIF3A; EFCAB7
CXCR4-mediated signaling events
GNB2L1; MAPKAP1; CSK; DNM1; GNA13; CRK; PAG1; ADRBK1; CFL1; BLK
Ca-dependent events
ADCY9; PRKAR1AA; ADRBK1; ADCY7
CaM pathway
PRKAR1AA; ADRBK1
Calmodulin induced events
PRKAR1AA; ADRBK1
Chemokine signaling pathway
CCL22; VAV2; GNG7; GM2506; Cxcl15; SOS1; CCR6; CCL4L2; GM13304; RAP1A
DAG and IP3 signaling
ADRBK1; PRKAR1AA; AHCYL1
DAP12 interactions
NEFLB; GRAP2B; FGF20A; DAB2IPB; DUSP5; FGF10B; NRG4; DUSP9; WDR83; SPNA1

Protein Function

ADRBK1 has several biochemical functions, for example, ATP binding, Edg-2 lysophosphatidic acid receptor binding, G-protein coupled receptor kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ADRBK1 itself. We selected most functions ADRBK1 had, and list some proteins which have the same functions with ADRBK1. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein PKZ; ATP1A1B; HELLS; MYO5C; AKT2; AURKC; PSMC4; ORC4; UBE2IB; HIPK2
Function Edg-2 lysophosphatidic acid receptor binding
Related Protein ADRBK1
Function G-protein coupled receptor kinase activity
Related Protein RLN1; GRK7B; ADRBK1; GRK1B; GRK7A; GRK6; GRK4; GRK1A; GRK5; GRK7
Function alpha-2A adrenergic receptor binding
Related Protein UCHL1; ADRB1; ADRA2C; ADRBK1; APLP1
Function beta-adrenergic receptor kinase activity
Related Protein GRK5; ADRBK2; ADRBK1; GRK6
Function protein binding
Related Protein AOC3; VEGFB; STYK1; KRTAP10-5; TAF10; ENSA; CD200R3; CFI; ITGA6; TNFRSF11A
Function protein kinase activity
Related Protein PAK1; EIF2AK3; PRKACAB; CAMK1DB; ROCK2B; BMPR1AB; PKZ; ERBB4A; PRKCDA; RPS6KA6

Interacting Protein

ADRBK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADRBK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADRBK1.
UBC; FPR1; EGFR; HDAC6; GIT1; TUBB; MDM2

ADRBK1 Related Articles

Wex, E; Thaler, E; et al. A Novel Model of IgE-Mediated Passive Pulmonary Anaphylaxis in Rats. PLOS ONE 9:-(2014).
Hartung, JE; Ciszek, BP; et al. beta(2)- and beta(3)-adrenergic receptors drive COMT-dependent pain by increasing production of nitric oxide and cytokines. PAIN 155:1346-1355(2014).

ADRBK1 Related Gene Family

GPCRs