adrbk2
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  • Official Full Name
  • adrenergic, beta, receptor kinase 2
  • Background
  • The beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic and;related G protein-coupled receptors. Overall, the beta adrenergic receptor kinase 2 has 85% amino acid similarity with;beta adrenergic receptor kinase 1, with the protein kinase catalytic domain having 95% similarity. These data suggest;the existence of a family of receptor kinases which may serve broadly to regulate receptor function.
  • Synonyms
  • ADRBK2; adrenergic, beta, receptor kinase 2; beta-adrenergic receptor kinase 2; BARK2; GRK3; beta-ARK-2; G-protein-coupled receptor kinase 3
Cat.#:ADRBK2-385HTag:GST
Source (Host):Insect CellSpecies:Human
Product nameRecombinant Human ADRBK2 Protein, GST-tagged
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Cat.#:ADRBK2-386HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ADRBK2 Protein, GST-tagged
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Cat.#:ADRBK2-387HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ADRBK2 Protein, GST-tagged
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Cat.#:ADRBK2-547RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat ADRBK2 Protein
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Cat.#:ADRBK2-7175ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish ADRBK2
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Cat.#:ADRBK2-1179HTag:GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Adrenergic, Beta, Receptor Kinase 2, GST-tagged
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Cat.#:ADRBK2-13HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human ADRBK2 lysate
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Involved Pathway

ADRBK2 involved in several pathways and played different roles in them. We selected most pathways ADRBK2 participated on our site, such as Chemokine signaling pathway, Corticotropin-releasing hormone, Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with ADRBK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Chemokine signaling pathway
GM1987; Ccl21a; CXCL6; CX3CR1; PRKCZ; GNB2; PRKACA; CCR7; GRK5; LYN
Corticotropin-releasing hormone
CRHR2; KRT14; CRH; TFAP2A; TBX19; JUND; KRT1; TCF4; CRHBP; CYP11A1
Endocytosis
ARPC5; WIPF2B; VPS37B; IGF1RB; SNX1A; ARF3A; STAMBP; TGFBR1A; PIP5K1A; TSG101
Glutamatergic synapse
GNG11; GNAI3; GRM8; GNG8; GRIA4; GRIN2D; MAPK3; SLC1A3; DLGAP1; PPP3CA
IL-4 signaling Pathway
ADRBK2; IL4R.1; PAWR; DOK2; HMGA1-RS1; SPI1B
Morphine addiction
GNAI2; GABRB3; GABRG2; PDE11A; GABRG1; PDE8B; GABRA2; GABRR2; GABRQ; PDE4D
Olfactory transduction
OR4D6; OR2K2; OR12D2; OLFR151; OLFR5; OLFR8; OR4N4; CALM4; OLFR478; PRKG1
Thromboxane A2 receptor signaling
SLC9A3R1; ARR3; ADRBK2

Protein Function

ADRBK2 has several biochemical functions, for example, ATP binding, G-protein coupled receptor kinase activity, beta-adrenergic receptor kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ADRBK2 itself. We selected most functions ADRBK2 had, and list some proteins which have the same functions with ADRBK2. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein UBE2A; FYN; TTLL9; SUCLG2; NMRK1; RARS; PSMC5; ROCK2A; ATP2B1; ACSM4
Function G-protein coupled receptor kinase activity
Related Protein ADRBK2; GRK1; GRK7A; GRK7; GRK4; GRK7B; ADRBK1; RLN1; GRK1B; GRK1A
Function beta-adrenergic receptor kinase activity
Related Protein ADRBK1; ADRBK2; GRK5; GRK6
Function protein kinase activity
Related Protein MAPK12B; PINK1; EK1; INSRB; CDK17; Aatk; PTK2; CHEK1; LTK; STK4

Interacting Protein

ADRBK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ADRBK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ADRBK2.
Opn4; HSPB1; groL; 15-deoxy-delta(12,14; ADRBK1

ADRBK2 Related Articles

Wex, E; Thaler, E; et al. A Novel Model of IgE-Mediated Passive Pulmonary Anaphylaxis in Rats. PLOS ONE 9:-(2014).
Rahbek-Clemmensen, T; Bay, T; et al. The Serotonin Transporter Undergoes Constitutive Internalization and Is Primarily Sorted to Late Endosomes and Lysosomal Degradation. JOURNAL OF BIOLOGICAL CHEMISTRY 289:23004-23019(2014).