AGT

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AGT

Official Full Name angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
Background The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease.
Synonyms AGT; angiotensinogen (serpin peptidase inhibitor, clade A, member 8); ANHU; SERPINA8
    • Species :
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • E.Coli or Yeast
    • HEK293
    • HEK293F
    • Human Cell
    • Human Plasma
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • S
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human AGT-152H Native Human Angiotensinogen Human Plasma N/A
    Human AGT-2181H Recombinant Human AGT, His tagged Human Cell His
    Human AGT-2182H Recombinant Human Angiotensinogen, His-tagged E.coli His
    Human AGT-2183H Recombinant Human Angiotensinogen, His&GST-tagged E.coli His/GST
    Human AGT-2575HCL Recombinant Human AGT cell lysate Human Cell N/A
    Human AGT-442H Recombinant Human AGT Protein, GST-tagged Wheat Germ GST
    Human AGT-517H Recombinant Human AGT Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human AGT-52H Human Angiotensin II Reference standard N/A
    Human AGT-53H Human Angiotensin I Reference standard N/A
    Human AGT-81H Human Angiotensin I(Synthetic) Reference standard N/A
    Mouse Agt-01M Recombinant Mouse Agt Protein HEK293 N/A
    Mouse AGT-1842MCL Recombinant Mouse AGT cell lysate Human Cell N/A
    Mouse Agt-253M Recombinant Mouse Agt protein, His/S-tagged E.coli His/S
    Mouse Agt-526M Recombinant Mouse Agt protein, His-tagged HEK293F His
    Mouse Agt-6860M Recombinant Mouse Agt, His tagged Human Cell His
    Rat Agt-1159R Recombinant Rat Agt Protein, His-tagged HEK293 His
    Rat Agt-254R Recombinant Rat Agt protein, His/S-tagged E.coli His/S
    Rat Agt-3459R Recombinant Rat Agt, His-tagged E.Coli or Yeast His
    Rat Agt-510R Recombinant Rat Agt protein, His-tagged HEK293F His
    Rat AGT-565R Recombinant Rat AGT Protein Mammalian Cell His
    Zebrafish AGT-9786Z Recombinant Zebrafish AGT Mammalian Cell His

    AGT involved in several pathways and played different roles in them. We selected most pathways AGT participated on our site, such as ACE Inhibitor Pathway, Adipogenesis, Class A/1 (Rhodopsin-like receptors), which may be useful for your reference. Also, other proteins which involved in the same pathway with AGT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    ACE Inhibitor Pathway AGTR2; ACE; ATP6AP2; AGTR1; CMA1; CYP11B2; CTSG; AGT
    Adipogenesis MIXL1; NAMPT; GDF10; HMGA1-RS1; CISD1; RETN; E2F1; NRIP1; SMAD3B; AGPAT2
    Class A/1 (Rhodopsin-like receptors) SSTR4; APLNR; INSL5; PENKB; QRFPR; ADORA3; OXGR1A.3; UTS2D; OXER1; EDN1
    Fatty acid, triacylglycerol, and ketone body metabolism GRHL1; ACOT11A; CDK8; MED31; CDK19; MED7; MED6; ACOT12; G0S2; STIL
    G alpha (i) signalling events SST; SSTR2; OPN1SW; SOUL3; OXGR1A.2; CCL27; RGS12; POMCB; RGS11; ADORA1
    G alpha (q) signalling events LPAR2A; ABHD6B; NMBB; GRP; NMU; GPR4; ABHD12; ANXA1C; APPB; PROKR2
    GPCR downstream signaling CALCA; ADORA2B; OPN1SW; RAMP2; OPN1MW2; OR2AP1; CNR1; NTS; DRD5; CCL27
    GPCR ligand binding DRD3; EMR2; HEBP1; EMR4; LPAR1; TAS2R3; ADORA3; CCL35.1; GPR132; SST1.1

    AGT has several biochemical functions, for example, growth factor activity, hormone activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AGT itself. We selected most functions AGT had, and list some proteins which have the same functions with AGT. You can find most of the proteins on our site.

    Function Related Protein
    growth factor activity FGF4; FGF11; WISP3; MSTN; AMBN; KLK1B3; PGF; IL9; FGF3; NRG3
    hormone activity STC1; GIP; Gh; IFNT2; C1QTNF9; THPO; NPPC; METRNL; FSD1; CHGB
    protein binding ANKRD32; COL23A1; SNX33; LBR; PGRMC1; SMAP2; USH1G; TNFSF14; CLOCKB; TCEA2
    serine-type endopeptidase inhibitor activity PAPLN; SERPINH1; SERPING1; OVST; WFDC13; SPINLW1; WFDC6A; SERPINB1L1; SERPINB1L4; WFDC6B
    sodium channel regulator activity SCN3B; NEDD4L; AGT; TMPRSS3; FXYD2; FXYD6; FXYD7; CAV3; PTPN3; YWHAH
    superoxide-generating NADPH oxidase activator activity AGT; NOXA1; NCF4; NOXO1; PDGFB
    type 1 angiotensin receptor binding GNA13; GNG3; AGT; GNA13A; JAK2; ARRB2; BDKRB2; TYK2; GNB1; ARAP1
    type 2 angiotensin receptor binding AGT

    AGT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AGT here. Most of them are supplied by our site. Hope this information will be useful for your research of AGT.

    Ance; Agtr1; f_hcvh; GRB2; EWSR1; GSDMB

    Betensky, M; Witmer, C; et al. Immune hemolytic anemia with drug-induced antibodies to carboplatin and vincristine in a pediatric patient with an optic pathway glioma. TRANSFUSION 54:2901-2905(2014).
    Dihazi, H; Dihazi, GH; et al. Secretion of ERP57 is important for extracellular matrix accumulation and progression of renal fibrosis, and is an early sign of disease onset. JOURNAL OF CELL SCIENCE 126:3649-3663(2013).

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