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AKAP12

  • Official Full Name

    A kinase (PRKA) anchor protein 12

  • Overview

    The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed in endothelial cells, cultured fibroblasts, and osteosarcoma cells. It associates with protein kinases A and C and phosphatase, and serves as a scaffold protein in signal transduction. This protein and RII PKA colocalize at the cell periphery. This protein is a cell growth-related protein. Antibodies to this protein can be produced by patients with myasthenia gravis. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
  • Synonyms

    AKAP12; A kinase (PRKA) anchor protein 12; SSeCKS; AKAP250; A-kinase anchor protein 12; AKAP 250; kinase scaffold protein gravin; A-kinase anchor protein, 250kDa; Src-Suppressed C Kinase Substrate; myasthenia gravis autoantigen gravin;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Rat
  • Rhesus Macaque
  • E.coli
  • HEK293
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human AKAP12-398H Recombinant Human AKAP12 Protein, GST-tagged Wheat Germ GST
Human AKAP12-8983H Recombinant Human AKAP12 protein, His-tagged E.coli His Pro1485~Ser1782
Human AKAP12-8941HCL Recombinant Human AKAP12 293 Cell Lysate HEK293 N/A
Rat AKAP12-588R Recombinant Rat AKAP12 Protein Mammalian Cell His
Rat AKAP12-244R Recombinant Rat AKAP12 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat AKAP12-244R-B Recombinant Rat AKAP12 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque AKAP12-287R Recombinant Rhesus monkey AKAP12 Protein, His-tagged Mammalian Cell His
Rhesus Macaque AKAP12-115R-B Recombinant Rhesus Macaque AKAP12 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque AKAP12-115R Recombinant Rhesus Macaque AKAP12 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein

AKAP12 involved in several pathways and played different roles in them. We selected most pathways AKAP12 participated on our site, such as G Protein Signaling Pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with AKAP12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
G Protein Signaling PathwaysGNB5B;AKAP6;AKAP4;KCNJ3;AKAP13;GNGT2A;AKAP7;ARHGEF1A;AKAP12B

AKAP12 has several biochemical functions, for example, adenylate cyclase binding, protein binding, protein kinase A binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AKAP12 itself. We selected most functions AKAP12 had, and list some proteins which have the same functions with AKAP12. You can find most of the proteins on our site.

Function Related Protein
adenylate cyclase bindingCALM1;ADCYAP1R1;AKAP5;ADRB2;CHRNA7;AKAP12;AKAP6;CALM3;CALM2
protein bindingPLSCR1;HMGB2;STX11;ZBP1;IRF2;SPATA2;KDM2B;C11orf67;PEBP1
protein kinase A bindingAkap3;NBEA;AKAP5;AKAP12B;DACT3;DACT2;RARA;AKAP13;Akap2

AKAP12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AKAP12 here. Most of them are supplied by our site. Hope this information will be useful for your research of AKAP12.

FHL1; EGFR; PRKAR2A; CTNNB1; PDE4D; Akap12; yknZ

  • Q&As
  • Reviews

Q&As (17)

Ask a question
Are there any ongoing clinical trials or research studies focused on AKAP12 in cancer? 05/03/2023

As of now, there are limited clinical trials or research studies specifically focused on AKAP12 as a target in cancer. Most of the studies investigating AKAP12 in cancer have been preclinical in nature, involving in vitro and in vivo models.

Are there any genetic variants or mutations in the AKAP12 gene? 03/24/2023

Genetic variants and mutations in the AKAP12 gene have been identified, but their specific implications and associations with diseases are currently being studied. For example, in breast cancer, specific polymorphisms and mutations in AKAP12 have been reported, but more research is needed to determine their role in cancer development and progression.

Are there any post-translational modifications known to occur on AKAP12? 05/04/2022

Yes, post-translational modifications have been identified on AKAP12. Phosphorylation of AKAP12 by protein kinases, such as protein kinase C (PKC) and protein kinase A (PKA), can regulate its interactions with other proteins and its cellular functions. Phosphorylation can modulate its ability to bind to cytoskeletal proteins and modulate cell migration and adhesion. Furthermore, AKAP12 can undergo proteolytic cleavage, generating fragments with distinct functions.

Is AKAP12 involved in cancer development? 11/24/2020

Yes, there is evidence suggesting that AKAP12 may play a role in cancer development. It has been found to be downregulated or lost in several types of cancers, including breast, prostate, lung, and liver cancer. AKAP12 loss is associated with increased cell proliferation, invasion, and metastasis. Its downregulation may contribute to the progression of cancer by altering signaling pathways involved in cell adhesion, migration, and invasion.

Is AKAP12 found in all cell types? 11/19/2020

AKAP12 is ubiquitously expressed in various cell types and tissues. It has been detected in epithelial cells, fibroblasts, endothelial cells, neurons, and various cancer cell lines. Its widespread expression suggests that it may have important functions in multiple cell types and physiological processes.

What techniques are used to study AKAP12 protein? 08/26/2020

Several techniques are used to study AKAP12 protein, including Western blotting, immunofluorescence microscopy, co-immunoprecipitation, and mass spectrometry. These techniques help determine AKAP12 expression levels, subcellular localization, interacting proteins, and post-translational modifications. Knockdown or overexpression experiments using siRNA or gene transfection methods can also be performed to investigate the functional implications of AKAP12 in cellular processes.

Can AKAP12 be used as a prognostic marker in cancer? 08/23/2020

AKAP12 expression alterations have been associated with prognosis in various cancers. In some cases, decreased AKAP12 expression is associated with poorer prognosis and worse clinical outcomes, indicating its potential as a prognostic marker.

Are there any drugs or therapeutic agents targeting AKAP12? 07/03/2020

Currently, there are no specific drugs or therapeutic agents targeting AKAP12. However, given AKAP12's potential tumor-suppressive functions and its involvement in cancer progression, there is growing interest in developing therapeutic strategies that can restore or enhance AKAP12 expression or function.

Can AKAP12 be used as a therapeutic target? 09/25/2019

AKAP12 has been proposed as a potential therapeutic target, particularly in cancer treatment. Restoring or enhancing AKAP12 expression in cancer cells may inhibit their proliferation, migration, and invasion. Additionally, modulating AKAP12 interactions with other proteins or intracellular signaling pathways could help regulate cellular processes involved in disease progression. However, further research is needed to fully understand AKAP12's mechanisms and the therapeutic potential of targeting it.

Does AKAP12 interact with other proteins? 04/10/2019

Yes, AKAP12 interacts with a variety of proteins involved in intracellular signaling and cytoskeletal organization. It can interact with kinases such as PKA, PKC, and Src, as well as phosphatases like protein phosphatase 1 (PP1). AKAP12 also binds to actin cytoskeleton-associated proteins such as filamin and vinculin, indicating its involvement in cytoskeletal organization and cell adhesion.

What cellular processes does AKAP12 regulate? 03/26/2019

AKAP12 regulates several cellular processes including cell adhesion, cell migration, differentiation, apoptosis, and cell cycle progression. It interacts with various intracellular signaling molecules and enzymes, acting as a scaffold to organize their activities and modulate their signaling pathways.

How is the expression of AKAP12 regulated in cancer? 01/17/2018

The expression of AKAP12 can be regulated at multiple levels in cancer. Several transcription factors have been found to modulate AKAP12 expression, including p53, TWIST1, and Snail1. These transcription factors can bind to the promoter region of AKAP12 and either activate or repress its transcription. Additionally, epigenetic modifications, such as DNA methylation and histone acetylation, can also influence AKAP12 expression. In some cancers, AKAP12 promoter hypermethylation has been observed, leading to decreased expression. Other regulatory mechanisms include microRNAs and long non-coding RNAs, which can target AKAP12 mRNA and decrease its stability or translation efficiency.

Are there any known diseases associated with AKAP12 dysfunction? 06/30/2017

While AKAP12 dysregulation has primarily been linked to cancer progression, alterations in AKAP12 expression or function have also been observed in other diseases. For example, reduced AKAP12 levels have been reported in cardiovascular diseases such as atherosclerosis and hypertension. Further research is needed to fully understand the implications of AKAP12 dysfunction in these diseases.

Are there any genetic mutations or alterations in AKAP12 that contribute to cancer development? 06/15/2016

While genetic mutations in AKAP12 are not frequently reported in cancer, alterations in its expression and methylation status are commonly observed. However, some studies have identified specific genetic alterations in AKAP12 that may contribute to cancer.

Does AKAP12 have any other physiological functions besides its involvement in cancer? 09/21/2015

Yes, AKAP12 is involved in various physiological processes beyond cancer. It has been implicated in cardiovascular development and function, neuronal development and plasticity, bone formation, immune response regulation, and wound healing. AKAP12 is a multifunctional protein that interacts with numerous signaling molecules and modulates various cellular pathways. Its functions can vary depending on the cell type and context, highlighting its versatility and importance in maintaining cellular homeostasis and proper physiological functioning.

Can AKAP12 be used as a therapeutic target in cancer treatment? 05/11/2015

The tumor-suppressive functions of AKAP12 make it an attractive therapeutic target in cancer treatment. Restoring or enhancing AKAP12 expression or function may be beneficial in inhibiting tumor growth, invasion, and metastasis.

Can AKAP12 be used as a diagnostic marker? 04/05/2015

While AKAP12 expression alterations have been observed in certain diseases, its use as a diagnostic marker is still under investigation. Further research is needed to determine the specificity and sensitivity of AKAP12 as a diagnostic marker for different diseases and explore its potential as a biomarker for disease diagnosis or prognosis.

Customer Reviews (4)

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Reviews
08/14/2022

    Their prompt and efficient assistance significantly contributes to the smooth progression of my experiments.

    10/06/2019

      This protein offers a level of unparalleled purity and functionality, giving me the utmost confidence in obtaining reliable and reproducible results in my research.

      07/12/2019

        Its specific characteristics align perfectly with my experimental objectives, making it an ideal choice for my scientific investigations.

        10/26/2017

          The protein was of very high quality in Western Blotting experiments

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