AKAP8
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Official Full Name
A kinase (PRKA) anchor protein 8
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Overview
This gene encodes a member of the A-kinase anchor protein family. A-kinase anchor proteins are scaffold proteins that contain a binding domain for the RI/RII subunit of protein kinase A (PKA) and recruit PKA and other signaling molecules to specific subcellular locations. This gene encodes a nuclear A-kinase anchor protein that binds to the RII alpha subunit of PKA and may play a role in chromosome condensation during mitosis by targeting PKA and the condensin complex to chromatin. A pseudogene of this gene is located on the short arm of chromosome 9. -
Synonyms
AKAP8; A kinase (PRKA) anchor protein 8; A-kinase anchor protein 8; A kinase anchor protein; 95kDa; AKAP95; DKFZp586B1222; A-kinase anchor protein, 95kDa; AKAP-8; AKAP 95; AKAP-95;
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | AKAP8-3032H | Recombinant Human AKAP8, His-tagged | E.Coli or Yeast | His | 692 | |
Human | AKAP8-403H | Recombinant Human AKAP8 Protein, GST-tagged | Wheat Germ | GST | ||
Human | AKAP8-46HCL | Recombinant Human AKAP8 cell lysate | N/A | |||
Human | AKAP8-1354HF | Recombinant Full Length Human AKAP8 Protein, GST-tagged | In Vitro Cell Free System | GST | 692 amino acids |
- Involved Pathway
- Protein Function
- Interacting Protein
AKAP8 involved in several pathways and played different roles in them. We selected most pathways AKAP8 participated on our site, such as G Protein Signaling Pathways, TNF-alpha/NF-kB Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with AKAP8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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G Protein Signaling Pathways | GNA13;AKAP10;AKAP8;KCNJ3;GNG13B;GNB5B;AKAP7;Akap3;AKAP12B |
TNF-alpha/NF-kB Signaling Pathway | RNF216;USP2;CSNK2A1P;PFDN2;MCC;DPF2;CAPN3;MARK2;PPP1R13L |
AKAP8 has several biochemical functions, for example, double-stranded DNA binding, poly(A) RNA binding, protein kinase A regulatory subunit binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AKAP8 itself. We selected most functions AKAP8 had, and list some proteins which have the same functions with AKAP8. You can find most of the proteins on our site.
Function | Related Protein |
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double-stranded DNA binding | TDG;TDP1;HMGB1;RAD51D;GATA1A;GTF2H4;MTERFD3;XRCC2;ERCC5 |
poly(A) RNA binding | PEF1;TCOF1;EIF2S2;ERH;ARCN1;MTDH;RPL13A;EIF2S1;LARP4B |
protein kinase A regulatory subunit binding | AKAP1;ARFGEF1;RYR2;ARFGEF2;C2orf88;PJA2;AKAP7;AKAP8;EZR |
zinc ion binding | ZNF207;NR2C2;ZZEF1;ESRRGB;ADAM10B;APOBEC2B;FHL2B;TRIM46B;UBR4 |
AKAP8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AKAP8 here. Most of them are supplied by our site. Hope this information will be useful for your research of AKAP8.
MYC; ESR1; CSNK2A1; Aurkb; Mis12; SCHIP1; ssrna_ug; E2F3; HNRNPA1; MATR3; YBX1; ILK; LRRK2; HIPK4; ESR2; HDAC11
- Q&As
- Reviews
Q&As (14)
Ask a questionAt present, there are no known drugs or compounds specifically targeting AKAP8. However, as our knowledge of AKAP8's roles and interactions expands, it is possible that specific inhibitors or modulators could be developed in the future.
AKAP8 is primarily localized within the nucleus of the cell. It is found in both the nucleoplasm and at specific sites within the nucleus, such as the nucleolus and nuclear matrix. AKAP8 interacts with various nuclear proteins and structures to regulate their activities and facilitate cellular functions.
Yes, AKAP8 is involved in DNA replication and repair processes. It interacts with proteins involved in DNA replication initiation and progression, such as DNA polymerase α and the minichromosome maintenance complex. AKAP8 also participates in DNA repair pathways by interacting with DNA repair factors, such as the nucleotide excision repair protein XPA.
At present, there are no known human genetic disorders specifically attributed to mutations in AKAP8. However, dysregulation of AKAP8 expression or function has been associated with various diseases, including cancer, neurodevelopmental disorders, and cardiovascular conditions. Further research is needed to determine the extent of AKAP8's involvement in these disorders and potential therapeutic applications.
Future research on AKAP8 may involve further elucidation of its intricate molecular mechanisms and protein interactions. Investigating its role in specific diseases and exploring therapeutic strategies targeting AKAP8 could be potential areas of focus. Additionally, understanding how AKAP8 contributes to development, differentiation, and tissue homeostasis may provide insights into its broader physiological functions.
While AKAP8 dysregulation has been observed in certain diseases, it is yet to be established as a reliable diagnostic marker for specific conditions. However, the identification of AKAP8 expression patterns or protein levels in certain tissues or patient samples may provide valuable insights and potential diagnostic indicators in the future.
Yes, animal models with altered expression or function of AKAP8 have been developed to study its roles in various biological processes. These models include mice with AKAP8 gene deletions or mutations. By studying these models, researchers aim to unravel the specific functions of AKAP8 and its contributions to disease development and progression.
Yes, AKAP8 contributes to DNA packaging and chromatin structure through its interactions with chromatin remodeling enzymes. It facilitates the recruitment of these enzymes to specific gene promoters, resulting in alterations to chromatin structure and accessibility for transcription factors and regulatory proteins.
Yes, AKAP8 has been shown to interact with other signaling molecules and modulate their activities. For instance, AKAP8 can associate with protein phosphatase 2A (PP2A) and regulate its localization and function in the nucleus. AKAP8 has also been reported to influence the activity of the c-Jun N-terminal kinase (JNK) signaling pathway, which is involved in cellular stress responses and apoptosis.
There is limited information available on genetic variations in the AKAP8 gene. However, some studies have reported single nucleotide polymorphisms (SNPs) in AKAP8 that may be associated with certain diseases or traits. For example, a SNP in AKAP8 has been associated with an increased risk of developing ischemic stroke. Further research is needed to explore the potential significance of these variations and their impact on AKAP8 function and disease susceptibility.
AKAP8 is involved in various stages of the cell cycle and helps coordinate cell cycle progression. It interacts with cyclins and cyclin-dependent kinases (CDKs) to regulate their activities and facilitate cell cycle transitions. AKAP8 also plays a role in the regulation of mitotic spindle assembly and chromosome segregation during cell division.
Research suggests that abnormalities in AKAP8 function may be associated with certain diseases. For example, altered expression of AKAP8 has been observed in various cancers, including breast, ovarian, and colorectal cancers. Dysfunction of AKAP8 in these cases may contribute to abnormal cell proliferation, tumor growth, and metastasis.
Targeting AKAP8 may hold potential for therapeutic interventions in diseases where its dysregulation plays a significant role. For example, in certain cancers, inhibiting AKAP8's interactions with other proteins or disrupting its localization could potentially hinder tumor growth and metastasis. However, further research is needed to fully understand the complex functions of AKAP8 and its potential as a therapeutic target.
Current research on AKAP8 spans various fields, including cancer biology, neurodevelopmental disorders, gene regulation, and cellular signaling. Some areas of active investigation include understanding the molecular mechanisms by which AKAP8 influences gene expression, characterizing its interactions with other proteins in different cellular contexts, and exploring its potential as a therapeutic target in diseases such as cancer and neurological disorders.
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