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AKAP8

  • Official Full Name

    A kinase (PRKA) anchor protein 8

  • Overview

    This gene encodes a member of the A-kinase anchor protein family. A-kinase anchor proteins are scaffold proteins that contain a binding domain for the RI/RII subunit of protein kinase A (PKA) and recruit PKA and other signaling molecules to specific subcellular locations. This gene encodes a nuclear A-kinase anchor protein that binds to the RII alpha subunit of PKA and may play a role in chromosome condensation during mitosis by targeting PKA and the condensin complex to chromatin. A pseudogene of this gene is located on the short arm of chromosome 9.
  • Synonyms

    AKAP8; A kinase (PRKA) anchor protein 8; A-kinase anchor protein 8; A kinase anchor protein; 95kDa; AKAP95; DKFZp586B1222; A-kinase anchor protein, 95kDa; AKAP-8; AKAP 95; AKAP-95;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human AKAP8-3032H Recombinant Human AKAP8, His-tagged E.Coli or Yeast His 692
Human AKAP8-403H Recombinant Human AKAP8 Protein, GST-tagged Wheat Germ GST
Human AKAP8-46HCL Recombinant Human AKAP8 cell lysate N/A
Human AKAP8-1354HF Recombinant Full Length Human AKAP8 Protein, GST-tagged In Vitro Cell Free System GST 692 amino acids
  • Involved Pathway
  • Protein Function
  • Interacting Protein

AKAP8 involved in several pathways and played different roles in them. We selected most pathways AKAP8 participated on our site, such as G Protein Signaling Pathways, TNF-alpha/NF-kB Signaling Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with AKAP8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
G Protein Signaling PathwaysGNA13;AKAP10;AKAP8;KCNJ3;GNG13B;GNB5B;AKAP7;Akap3;AKAP12B
TNF-alpha/NF-kB Signaling PathwayRNF216;USP2;CSNK2A1P;PFDN2;MCC;DPF2;CAPN3;MARK2;PPP1R13L

AKAP8 has several biochemical functions, for example, double-stranded DNA binding, poly(A) RNA binding, protein kinase A regulatory subunit binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AKAP8 itself. We selected most functions AKAP8 had, and list some proteins which have the same functions with AKAP8. You can find most of the proteins on our site.

Function Related Protein
double-stranded DNA bindingTDG;TDP1;HMGB1;RAD51D;GATA1A;GTF2H4;MTERFD3;XRCC2;ERCC5
poly(A) RNA bindingPEF1;TCOF1;EIF2S2;ERH;ARCN1;MTDH;RPL13A;EIF2S1;LARP4B
protein kinase A regulatory subunit bindingAKAP1;ARFGEF1;RYR2;ARFGEF2;C2orf88;PJA2;AKAP7;AKAP8;EZR
zinc ion bindingZNF207;NR2C2;ZZEF1;ESRRGB;ADAM10B;APOBEC2B;FHL2B;TRIM46B;UBR4

AKAP8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AKAP8 here. Most of them are supplied by our site. Hope this information will be useful for your research of AKAP8.

MYC; ESR1; CSNK2A1; Aurkb; Mis12; SCHIP1; ssrna_ug; E2F3; HNRNPA1; MATR3; YBX1; ILK; LRRK2; HIPK4; ESR2; HDAC11

  • Q&As
  • Reviews

Q&As (14)

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Are there any known drugs or compounds that specifically target AKAP8? 07/19/2022

At present, there are no known drugs or compounds specifically targeting AKAP8. However, as our knowledge of AKAP8's roles and interactions expands, it is possible that specific inhibitors or modulators could be developed in the future.

Where is AKAP8 localized within the cell? 12/26/2021

AKAP8 is primarily localized within the nucleus of the cell. It is found in both the nucleoplasm and at specific sites within the nucleus, such as the nucleolus and nuclear matrix. AKAP8 interacts with various nuclear proteins and structures to regulate their activities and facilitate cellular functions.

Does AKAP8 have any role in DNA replication and repair? 08/06/2021

Yes, AKAP8 is involved in DNA replication and repair processes. It interacts with proteins involved in DNA replication initiation and progression, such as DNA polymerase α and the minichromosome maintenance complex. AKAP8 also participates in DNA repair pathways by interacting with DNA repair factors, such as the nucleotide excision repair protein XPA.

Are there any genetic disorders associated with mutations or dysregulation of AKAP8? 03/30/2021

At present, there are no known human genetic disorders specifically attributed to mutations in AKAP8. However, dysregulation of AKAP8 expression or function has been associated with various diseases, including cancer, neurodevelopmental disorders, and cardiovascular conditions. Further research is needed to determine the extent of AKAP8's involvement in these disorders and potential therapeutic applications.

What are potential future directions for AKAP8 research? 10/19/2020

Future research on AKAP8 may involve further elucidation of its intricate molecular mechanisms and protein interactions. Investigating its role in specific diseases and exploring therapeutic strategies targeting AKAP8 could be potential areas of focus. Additionally, understanding how AKAP8 contributes to development, differentiation, and tissue homeostasis may provide insights into its broader physiological functions.

Can AKAP8 be used as a diagnostic marker for certain diseases? 03/11/2019

While AKAP8 dysregulation has been observed in certain diseases, it is yet to be established as a reliable diagnostic marker for specific conditions. However, the identification of AKAP8 expression patterns or protein levels in certain tissues or patient samples may provide valuable insights and potential diagnostic indicators in the future.

Are there any animal models available to study AKAP8? 02/21/2019

Yes, animal models with altered expression or function of AKAP8 have been developed to study its roles in various biological processes. These models include mice with AKAP8 gene deletions or mutations. By studying these models, researchers aim to unravel the specific functions of AKAP8 and its contributions to disease development and progression.

Does AKAP8 have any involvement in DNA packaging and chromatin structure? 07/09/2018

Yes, AKAP8 contributes to DNA packaging and chromatin structure through its interactions with chromatin remodeling enzymes. It facilitates the recruitment of these enzymes to specific gene promoters, resulting in alterations to chromatin structure and accessibility for transcription factors and regulatory proteins.

Can AKAP8 affect cellular signaling pathways other than PKA signaling? 11/03/2017

Yes, AKAP8 has been shown to interact with other signaling molecules and modulate their activities. For instance, AKAP8 can associate with protein phosphatase 2A (PP2A) and regulate its localization and function in the nucleus. AKAP8 has also been reported to influence the activity of the c-Jun N-terminal kinase (JNK) signaling pathway, which is involved in cellular stress responses and apoptosis.

Are there any genetic variations or polymorphisms in the AKAP8 gene? 08/04/2017

There is limited information available on genetic variations in the AKAP8 gene. However, some studies have reported single nucleotide polymorphisms (SNPs) in AKAP8 that may be associated with certain diseases or traits. For example, a SNP in AKAP8 has been associated with an increased risk of developing ischemic stroke. Further research is needed to explore the potential significance of these variations and their impact on AKAP8 function and disease susceptibility.

How does AKAP8 contribute to cell cycle progression? 02/28/2017

AKAP8 is involved in various stages of the cell cycle and helps coordinate cell cycle progression. It interacts with cyclins and cyclin-dependent kinases (CDKs) to regulate their activities and facilitate cell cycle transitions. AKAP8 also plays a role in the regulation of mitotic spindle assembly and chromosome segregation during cell division.

Are there any specific diseases or disorders associated with AKAP8 dysfunction? 11/18/2016

Research suggests that abnormalities in AKAP8 function may be associated with certain diseases. For example, altered expression of AKAP8 has been observed in various cancers, including breast, ovarian, and colorectal cancers. Dysfunction of AKAP8 in these cases may contribute to abnormal cell proliferation, tumor growth, and metastasis.

Can AKAP8 be targeted therapeutically for certain diseases? 03/23/2016

Targeting AKAP8 may hold potential for therapeutic interventions in diseases where its dysregulation plays a significant role. For example, in certain cancers, inhibiting AKAP8's interactions with other proteins or disrupting its localization could potentially hinder tumor growth and metastasis. However, further research is needed to fully understand the complex functions of AKAP8 and its potential as a therapeutic target.

What are some current areas of research on AKAP8? 10/05/2015

Current research on AKAP8 spans various fields, including cancer biology, neurodevelopmental disorders, gene regulation, and cellular signaling. Some areas of active investigation include understanding the molecular mechanisms by which AKAP8 influences gene expression, characterizing its interactions with other proteins in different cellular contexts, and exploring its potential as a therapeutic target in diseases such as cancer and neurological disorders.

Customer Reviews (4)

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01/09/2022

    Its exceptional purity and reliability guarantee reliable and consistent results throughout my research endeavors.

    12/17/2019

      Their unwavering commitment to providing excellent assistance instills confidence that no obstacle is insurmountable.

      10/24/2019

        This combination ensures a transformative solution to my research problem, providing the necessary tools and assistance to achieve optimal results.

        08/13/2017

          With their guidance and expertise, I am confident that any hurdles I encounter will be efficiently addressed, allowing me to proceed with my research seamlessly.

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