akt3
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  • Official Full Name
  • v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)
  • Background
  • The protein encoded by this gene is a member of the AKT, also called PKB, serine/threonine protein kinase family. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. This kinase has been shown to be stimulated by platelet-derived growth factor (PDGF), insulin, and insulin-like growth factor 1 (IGF1). Alternatively splice transcript variants encoding distinct isoforms have been described.
  • Synonyms
  • AKT3; v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma); PKBG; PRKBG; STK-2; PKB-GAMMA; RAC-gamma; RAC-PK-gamma; DKFZp434N0250; RAC-gamma serine/threonine-protein kinase; PKB gamma; OTTHUMP00000037911; OTTHUMP00000037912; protein kinase Akt-3; protein kinase B gamma; serine threonine protein kinase, Akt-3
Cat.#:Akt3-159HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Akt3, His-tagged
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Cat.#:Akt3-162HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Akt3, GST-tagged
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Cat.#:AKT3-165HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human AKT3, Active, His-tagged
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Cat.#:AKT3-166HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human AKT3, His-tagged
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Cat.#:AKT3-2522HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human AKT3, Active
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Cat.#:AKT3-104HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human AKT3, GST-tagged, Active
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Cat.#:AKT3-131HTag:GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human AKT3, GST tagged
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Cat.#:AKT3-26HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human AKT3 (E17K), GST-tagged
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Cat.#:AKT3-308HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human AKT3 protein, His/MBP-tagged
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Cat.#:AKT3-426HTag:
Source (Host):Insect CellSpecies:Human
Product nameRecombinant Human AKT3 Protein
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Cat.#:AKT3-427HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human AKT3 Protein, GST-tagged
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Cat.#:AKT3-550HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human AKT3 Protein, His-tagged
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Cat.#:AKT3-804HTag:GST/His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human AKT3 protein, GST-His-tagged
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Cat.#:AKT3-549MTag:Fc
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse Akt3, None tagged
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Cat.#:Akt3-8694MTag:Fc
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse Akt3, His-GST tagged
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Cat.#:AKT3-607RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat AKT3 Protein
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Cat.#:AKT3-298RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey AKT3 Protein, His-tagged
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Cat.#:AKT3-1365HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human AKT3 (Active), GST-tagged
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Cat.#:AKT3-728HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human AKT3 cell lysate
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Cat.#:AKT3-001MCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Mouse
Product nameRecombinant Mouse AKT3 cell lysate
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Involved Pathway

AKT3 involved in several pathways and played different roles in them. We selected most pathways AKT3 participated on our site, such as AKT phosphorylates targets in the cytosol, AKT phosphorylates targets in the nucleus, AKT-mediated inactivation of FOXO1A, which may be useful for your reference. Also, other proteins which involved in the same pathway with AKT3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
AKT phosphorylates targets in the cytosol
CDKN1B; AKT3; CDKN1A; CHUK
AKT phosphorylates targets in the nucleus
CREB1; CREB1B; AKT3
AKT-mediated inactivation of FOXO1A
AKT3
AMPK signaling pathway
IGF1R; ACACB; CCND1; PDPK1; SIRT1; PIK3R5; PPP2R5C; FOXO3; PPP2R2B; CREB3L3
Activation of BAD and translocation to mitochondria
YWHAQ; CDK5RAP2; AKT3
Activation of BH3-only proteins
DYNLL2; YWHAQ; BCL2L11; CDK5RAP2; AKT3; E2F1
Acute myeloid leukemia
ZBTB16; RAF1; PIK3CG; PIK3R1; PIK3CB; PIK3R5; KRAS; RPS6KB1; CCND1; PIK3CA
Adaptive Immune System
DCTN2; ICAM4; WSB1; AGO1; FAM49BA; KIF3C; CSK; LILRA3; DZIP3; TREML1

Protein Function

AKT3 has several biochemical functions, for example, ATP binding, protein binding, protein kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AKT3 itself. We selected most functions AKT3 had, and list some proteins which have the same functions with AKT3. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein ABCB1A; DCKL1B; FIGNL1; CSNK1DB; TRPV4; RIPK4; DDX56; NAV3; PFKP; DNAJA3B
Function protein binding
Related Protein BAAT; ROPN1B; CPSF7; RPS6KA5; AMPD2; NFASC; CCDC55; C5orf20; DMAP1; CTDSP1
Function protein kinase activity
Related Protein PTK7A; PKMYT1; ERBB4A; MAP3K4; GM711; OXSR1A; CSNK1A1; CDK9; MKNK2B; WEE2
Function protein serine/threonine kinase activity
Related Protein PDIK1L; DCLK2; CDK11A; CAMK2G1; CDK14; CDK5; ALPK1; TAOK3; STK35L; SNRKA

Interacting Protein

AKT3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AKT3 here. Most of them are supplied by our site. Hope this information will be useful for your research of AKT3.
CASP3; CDC37; saicar; PKM; HSP90AA1; PRKCZ; HSP90AB1; NUDCD1

AKT3 Related Articles

Mias, GI; Chen, R; et al. Specific Plasma Autoantibody Reactivity in Myelodysplastic Syndromes. SCIENTIFIC REPORTS 3:-(2013).
Marchbank, T; Mahmood, A; et al. Pancreatic secretory trypsin inhibitor causes autocrine-mediated migration and invasion in bladder cancer and phosphorylates the EGF receptor, Akt2 and Akt3, and ERK1 and ERK2. AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY 305:F382-F389(2013).

AKT3 Related Gene Family

TGF