ALG3
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Official Full Name
asparagine-linked glycosylation 3, alpha-1,3- mannosyltransferase homolog (S. cerevisiae)
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Synonyms
D16Ertd36e;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Human
- Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
- Mouse
- Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume blotch fungus) (Parastagonospora nodorum)
- Zebrafish
- E.coli expression system
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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Human | ALG3-464H | Recombinant Human ALG3 Protein, GST-tagged | Wheat Germ | GST | ||
Human | ALG3-1434HF | Recombinant Full Length Human ALG3 Protein, GST-tagged | In Vitro Cell Free System | GST | 438 amino acids | |
Mouse | ALG3-1547M | Recombinant Mouse ALG3 Protein | Mammalian Cell | His | ||
Mouse | ALG3-467M | Recombinant Mouse ALG3 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Mouse | ALG3-467M-B | Recombinant Mouse ALG3 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) | RFL7856KF | Recombinant Full Length Kluyveromyces Lactis Dol-P-Man:Man(5)Glcnac(2)-Pp-Dol Alpha-1,3-Mannosyltransferase(Alg3) Protein, His-Tagged | E.coli expression system | His | Full Length (1-462) | |
Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume blotch fungus) (Parastagonospora nodorum) | RFL17072PF | Recombinant Full Length Phaeosphaeria Nodorum Dol-P-Man:Man(5)Glcnac(2)-Pp-Dol Alpha-1,3-Mannosyltransferase(Alg3) Protein, His-Tagged | E.coli expression system | His | Full Length (1-609) | |
Zebrafish | ALG3-2857Z | Recombinant Zebrafish ALG3 | Mammalian Cell | His |
- Involved Pathway
- Protein Function
- Interacting Protein
- ALG3 Related Articles
ALG3 involved in several pathways and played different roles in them. We selected most pathways ALG3 participated on our site, such as N-Glycan biosynthesis, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALG3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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N-Glycan biosynthesis | MGAT1;MGAT3A;MGAT4B;ALG8;MGAT5;DPM2;RABGNT1;MAN1A1;MGAT5B |
Metabolic pathways | MTMR8;SGPL1;BST1;LIPF;G6PCA.1;TDO2A;NADKD1;MECR;PNPLA3 |
ALG3 has several biochemical functions, for example, alpha-1,3-mannosyltransferase activity, dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity, transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ALG3 itself. We selected most functions ALG3 had, and list some proteins which have the same functions with ALG3. You can find most of the proteins on our site.
Function | Related Protein |
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alpha-1,3-mannosyltransferase activity | ALG8;B3GNTL1;GALNTL4;POC1BL;POMGNT2;4931440L10Rik;B3GNT8;DPY19L1;GALNT18A |
dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity | |
transferase activity | SULT1ST2;UGT1B2;GGACT.3;AK5L;DCLK3;AGPAT9L;PDXKB;ITPK1A;KEG1 |
transferase activity, transferring glycosyl groups | C1GALT1A;GCNT4A;UGT2A4;ST6GALNAC1.2;UGT5F1;GXYLT1;B3GAT1A;EXT1;ST6GALNAC5B |
transferase activity, transferring hexosyl groups | UGT5A4;PIGM;UGT5B2;UGT5D1;UGT8A;UGT1AB;UGT1B4;UGT2B5;UGT5A5 |
ALG3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALG3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ALG3.
- Q&As
- Reviews
Q&As (18)
Ask a questionThis protein plays an important role in some neurological diseases, such as central nervous system dysplasia, leading to symptoms such as mental retardation and muscle weakness.
No studies have confirmed whether ALG3 is involved in mitochondrial glucose metabolism, and more studies are needed to prove it.
ALG3 catalyzes the sugar chain transfer reaction between UDP-glucose and substrate proteins, synthesizing sugar chains onto proteins.
At present, there is no direct evidence that ALG3 is related to the occurrence and development of cancer, but glycosylation plays an important role in metabolism and disease development, so it may be relevant to related diseases.
The selectively catalyzes the synthesis and modification of sugar chains and plays an important role in the binding selectivity of glycosylase family members to substrate proteins.
The mutation may be associated with some genetic diseases, such as CDG (Congenital Disorder of Glycosylation).
ALG3 mutation may lead to the occurrence and development of some metabolic diseases such as CDG, and further investigation is needed to confirm its role in metabolic diseases.
This protein interacts with members of the glycosylase family such as ALG2, ALG1 and other related proteins to jointly regulate the glycosylation process of proteins.
ALG3 is mainly distributed in the endoplasmic reticulum and Golgi apparatus in mammalian cells.
ALG3 is involved in metabolic pathways such as glycosylation and glucose metabolism.
ALG3 plays an important role in protein glycosylation pathway, participating in the synthesis and modification of sugar chains.
Although there are currently no studies demonstrating the function of ALG3 in non-cellular autophagy pathways, there are indications that it may be involved in the TCA cycle and gluconeogenic pathways.
ALG3 is involved in several biological processes including protein glycosylation, ER and Golgi body sugar metabolism.
Overexpression or knockout of ALG3 can negatively affect the glycosylation of cells and the stability of ER and Golgi bodies, but the specific effects need to be further explored.
A number of inhibitors have been developed that target ALG3 and inhibit its glycosylation activity, thereby interfering with its function in cellular processes.
This protein mutations can have adverse effects on embryonic development and may therefore be associated with a number of fetal diseases.
The regulates the expression of glycosylase and the balance of glycosylation reaction by interacting with other glycosylated enzymes such as ALG2 and ALG1.
ALG3 gene contains 12 exons, and its expression is influenced by multiple regulatory elements and signaling pathways.
Customer Reviews (4)
Write a reviewALG3 has inhibitory or killing effects on specific pathogens.
This protein was found to have high sensitivity and specificity in biosensor preparation.
In drug screening experiments, ALG3 was found to have good selectivity for specific disease-related targets.
ALG3 can promote cell growth and proliferation in cell culture experiments.
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