Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953

ALG3

  • Official Full Name

    asparagine-linked glycosylation 3, alpha-1,3- mannosyltransferase homolog (S. cerevisiae)

  • Synonyms

    D16Ertd36e;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
  • Mouse
  • Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume blotch fungus) (Parastagonospora nodorum)
  • Zebrafish
  • E.coli expression system
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ALG3-464H Recombinant Human ALG3 Protein, GST-tagged Wheat Germ GST
Human ALG3-1434HF Recombinant Full Length Human ALG3 Protein, GST-tagged In Vitro Cell Free System GST 438 amino acids
Mouse ALG3-1547M Recombinant Mouse ALG3 Protein Mammalian Cell His
Mouse ALG3-467M Recombinant Mouse ALG3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse ALG3-467M-B Recombinant Mouse ALG3 Protein Pre-coupled Magnetic Beads HEK293
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) RFL7856KF Recombinant Full Length Kluyveromyces Lactis Dol-P-Man:Man(5)Glcnac(2)-Pp-Dol Alpha-1,3-Mannosyltransferase(Alg3) Protein, His-Tagged E.coli expression system His Full Length (1-462)
Phaeosphaeria nodorum (strain SN15 / ATCC MYA-4574 / FGSC 10173) (Glume blotch fungus) (Parastagonospora nodorum) RFL17072PF Recombinant Full Length Phaeosphaeria Nodorum Dol-P-Man:Man(5)Glcnac(2)-Pp-Dol Alpha-1,3-Mannosyltransferase(Alg3) Protein, His-Tagged E.coli expression system His Full Length (1-609)
Zebrafish ALG3-2857Z Recombinant Zebrafish ALG3 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ALG3 Related Articles

ALG3 involved in several pathways and played different roles in them. We selected most pathways ALG3 participated on our site, such as N-Glycan biosynthesis, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALG3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
N-Glycan biosynthesisMGAT1;MGAT3A;MGAT4B;ALG8;MGAT5;DPM2;RABGNT1;MAN1A1;MGAT5B
Metabolic pathwaysMTMR8;SGPL1;BST1;LIPF;G6PCA.1;TDO2A;NADKD1;MECR;PNPLA3

ALG3 has several biochemical functions, for example, alpha-1,3-mannosyltransferase activity, dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity, transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ALG3 itself. We selected most functions ALG3 had, and list some proteins which have the same functions with ALG3. You can find most of the proteins on our site.

Function Related Protein
alpha-1,3-mannosyltransferase activityALG8;B3GNTL1;GALNTL4;POC1BL;POMGNT2;4931440L10Rik;B3GNT8;DPY19L1;GALNT18A
dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity
transferase activitySULT1ST2;UGT1B2;GGACT.3;AK5L;DCLK3;AGPAT9L;PDXKB;ITPK1A;KEG1
transferase activity, transferring glycosyl groupsC1GALT1A;GCNT4A;UGT2A4;ST6GALNAC1.2;UGT5F1;GXYLT1;B3GAT1A;EXT1;ST6GALNAC5B
transferase activity, transferring hexosyl groupsUGT5A4;PIGM;UGT5B2;UGT5D1;UGT8A;UGT1AB;UGT1B4;UGT2B5;UGT5A5

ALG3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALG3 here. Most of them are supplied by our site. Hope this information will be useful for your research of ALG3.

Nasab, FP; Aebi, M; et al. A Combined System for Engineering Glycosylation Efficiency and Glycan Structure in Saccharomyces cerevisiae. APPLIED AND ENVIRONMENTAL MICROBIOLOGY 79:997-1007(2013).
Henquet, M; Eigenhuijsen, J; et al. Characterization of the single-chain Fv-Fc antibody MBP10 produced in Arabidopsis alg3 mutant seeds. TRANSGENIC RESEARCH 20:1033-1042(2011).
  • Q&As
  • Reviews

Q&As (18)

Ask a question
In what neurological diseases does ALG3 play a role? 02/09/2023

This protein plays an important role in some neurological diseases, such as central nervous system dysplasia, leading to symptoms such as mental retardation and muscle weakness.

Does ALG3 participate in mitochondrial glucose metabolism? 12/14/2022

No studies have confirmed whether ALG3 is involved in mitochondrial glucose metabolism, and more studies are needed to prove it.

What is the action mechanism of ALG3? 08/12/2022

ALG3 catalyzes the sugar chain transfer reaction between UDP-glucose and substrate proteins, synthesizing sugar chains onto proteins.

In which cancers does ALG3 play a role? 06/19/2022

At present, there is no direct evidence that ALG3 is related to the occurrence and development of cancer, but glycosylation plays an important role in metabolism and disease development, so it may be relevant to related diseases.

What is the sugar chain selectivity of ALG3? 08/22/2021

The selectively catalyzes the synthesis and modification of sugar chains and plays an important role in the binding selectivity of glycosylase family members to substrate proteins.

What diseases do ALG3 mutations cause? 08/07/2021

The mutation may be associated with some genetic diseases, such as CDG (Congenital Disorder of Glycosylation).

In what metabolic diseases does ALG3 play a role? 07/19/2021

ALG3 mutation may lead to the occurrence and development of some metabolic diseases such as CDG, and further investigation is needed to confirm its role in metabolic diseases.

What interaction proteins ALG3 will have? 05/01/2021

This protein interacts with members of the glycosylase family such as ALG2, ALG1 and other related proteins to jointly regulate the glycosylation process of proteins.

How is ALG3 distributed in mammalian cells? 01/04/2021

ALG3 is mainly distributed in the endoplasmic reticulum and Golgi apparatus in mammalian cells.

What metabolic pathways is ALG3 associated with? 05/29/2020

ALG3 is involved in metabolic pathways such as glycosylation and glucose metabolism.

What are the molecular biological characteristics of ALG3? 04/06/2020

ALG3 plays an important role in protein glycosylation pathway, participating in the synthesis and modification of sugar chains.

What non-cellular autophagy pathways are involved in ALG3? 04/06/2020

Although there are currently no studies demonstrating the function of ALG3 in non-cellular autophagy pathways, there are indications that it may be involved in the TCA cycle and gluconeogenic pathways.

What biological processes does ALG3 participate in? 03/03/2020

ALG3 is involved in several biological processes including protein glycosylation, ER and Golgi body sugar metabolism.

What effect does overexpression or knockout of ALG3 have on cells? 01/25/2020

Overexpression or knockout of ALG3 can negatively affect the glycosylation of cells and the stability of ER and Golgi bodies, but the specific effects need to be further explored.

What are the effects of ALG3 inhibitors? 11/20/2019

A number of inhibitors have been developed that target ALG3 and inhibit its glycosylation activity, thereby interfering with its function in cellular processes.

Does ALG3 mutation have an adverse effect on embryonic development? 10/22/2019

This protein mutations can have adverse effects on embryonic development and may therefore be associated with a number of fetal diseases.

Which cell signaling molecules are involved in ALG3? 09/22/2019

The regulates the expression of glycosylase and the balance of glycosylation reaction by interacting with other glycosylated enzymes such as ALG2 and ALG1.

What is the gene structure and regulation of ALG3? 06/11/2019

ALG3 gene contains 12 exons, and its expression is influenced by multiple regulatory elements and signaling pathways.

Customer Reviews (4)

Write a review
Reviews
10/18/2022

    ALG3 has inhibitory or killing effects on specific pathogens.

    08/01/2022

      This protein was found to have high sensitivity and specificity in biosensor preparation.

      06/09/2021

        In drug screening experiments, ALG3 was found to have good selectivity for specific disease-related targets.

        04/30/2021

          ALG3 can promote cell growth and proliferation in cell culture experiments.

          Ask a Question for All ALG3 Products

          Required fields are marked with *

          My Review for All ALG3 Products

          Required fields are marked with *

          logo

          FOLLOW US

          Terms and Conditions        Privacy Policy

          Copyright © 2024 Creative BioMart. All Rights Reserved.

          Contact Us

          • /

          Stay Updated on the Latest Bioscience Trends