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Recombinant Human ALG3 Protein, GST-tagged

Cat.No. : ALG3-464H
Product Overview : Human ALG3 full-length ORF ( NP_005778.1, 1 a.a. - 438 a.a.) recombinant protein with GST-tag at N-terminal.
  • Specification
  • Gene Information
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Description : This gene encodes a member of the ALG3 family. The encoded protein catalyses the addition of the first dol-P-Man derived mannose in an alpha 1,3 linkage to Man5GlcNAc2-PP-Dol. Defects in this gene have been associated with congenital disorder of glycosylation type Id (CDG-Id) characterized by abnormal N-glycosylation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 76.5 kDa
AA Sequence : MAAGLRKRGRSGSAAQAEGLCKQWL QRAWQERRLLLREPRYTLLVAACLC LAEVGITFWVIHRVAYTEIDWKAYM AEVEGVINGTYDYTQLQGDTGPLVY PAGFVYIFMGLYYATSRGTDIRMAQ NIFAVLYLATLLLVFLIYHQTCKVP PFVFFFMCCASYRVHSIFVLRLFND PVAMVLLFLSINLLLAQRWGWGCCF FSLAVSVKMNVLLFAPGLLFLLLTQ FGFRGALPKLGICAGLQVVLGLPFL LENPSGYLSRSFDLGRQFLFHWTVN WRFLPEALFLHRAFHLALLTAHLTL LLLFALCRWHRTGESILSLLRDPSK RKVPPQPLTPNQIVSTLFTSNFIGI CFSRSLHYQFYVWYFHTLPYLLWAM PARWLTHLLRLLVLGLIELSWNTYP STSCSSAALHICHAVILLQLWLGPQ PFPKSTQHSKKAH
Applications : Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : ALG3 ALG3, alpha-1,3- mannosyltransferase [ Homo sapiens (human) ]
Official Symbol : ALG3
Synonyms : ALG3; ALG3, alpha-1,3- mannosyltransferase; not; CDG1D; CDGS4; CDGS6; Not56; NOT56L; D16Ertd36e; dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase; Not56-like protein; asparagine-linked glycosylation 3 homolog (S. cerevisiae, alpha-1,3-mannosyltransferase); asparagine-linked glycosylation 3 homolog (yeast, alpha-1,3-mannosyltransferase); asparagine-linked glycosylation 3, alpha-1,3- mannosyltransferase homolog; asparagine-linked glycosylation protein 3 homolog; carbohydrate deficient glycoprotein syndrome type IV; dol-P-Man-dependent alpha(1-3)-mannosyltransferase; dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase; dolichyl-phosphate-mannose--glycolipid alpha-mannosyltransferase; EC 2.4.1.258
Gene ID : 10195
mRNA Refseq : NM_001006941
Protein Refseq : NP_001006942
MIM : 608750
UniProt ID : Q92685

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (18)

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In what neurological diseases does ALG3 play a role? 02/09/2023

This protein plays an important role in some neurological diseases, such as central nervous system dysplasia, leading to symptoms such as mental retardation and muscle weakness.

Does ALG3 participate in mitochondrial glucose metabolism? 12/14/2022

No studies have confirmed whether ALG3 is involved in mitochondrial glucose metabolism, and more studies are needed to prove it.

What is the action mechanism of ALG3? 08/12/2022

ALG3 catalyzes the sugar chain transfer reaction between UDP-glucose and substrate proteins, synthesizing sugar chains onto proteins.

In which cancers does ALG3 play a role? 06/19/2022

At present, there is no direct evidence that ALG3 is related to the occurrence and development of cancer, but glycosylation plays an important role in metabolism and disease development, so it may be relevant to related diseases.

What is the sugar chain selectivity of ALG3? 08/22/2021

The selectively catalyzes the synthesis and modification of sugar chains and plays an important role in the binding selectivity of glycosylase family members to substrate proteins.

What diseases do ALG3 mutations cause? 08/07/2021

The mutation may be associated with some genetic diseases, such as CDG (Congenital Disorder of Glycosylation).

In what metabolic diseases does ALG3 play a role? 07/19/2021

ALG3 mutation may lead to the occurrence and development of some metabolic diseases such as CDG, and further investigation is needed to confirm its role in metabolic diseases.

What interaction proteins ALG3 will have? 05/01/2021

This protein interacts with members of the glycosylase family such as ALG2, ALG1 and other related proteins to jointly regulate the glycosylation process of proteins.

How is ALG3 distributed in mammalian cells? 01/04/2021

ALG3 is mainly distributed in the endoplasmic reticulum and Golgi apparatus in mammalian cells.

What metabolic pathways is ALG3 associated with? 05/29/2020

ALG3 is involved in metabolic pathways such as glycosylation and glucose metabolism.

What are the molecular biological characteristics of ALG3? 04/06/2020

ALG3 plays an important role in protein glycosylation pathway, participating in the synthesis and modification of sugar chains.

What non-cellular autophagy pathways are involved in ALG3? 04/06/2020

Although there are currently no studies demonstrating the function of ALG3 in non-cellular autophagy pathways, there are indications that it may be involved in the TCA cycle and gluconeogenic pathways.

What biological processes does ALG3 participate in? 03/03/2020

ALG3 is involved in several biological processes including protein glycosylation, ER and Golgi body sugar metabolism.

What effect does overexpression or knockout of ALG3 have on cells? 01/25/2020

Overexpression or knockout of ALG3 can negatively affect the glycosylation of cells and the stability of ER and Golgi bodies, but the specific effects need to be further explored.

What are the effects of ALG3 inhibitors? 11/20/2019

A number of inhibitors have been developed that target ALG3 and inhibit its glycosylation activity, thereby interfering with its function in cellular processes.

Does ALG3 mutation have an adverse effect on embryonic development? 10/22/2019

This protein mutations can have adverse effects on embryonic development and may therefore be associated with a number of fetal diseases.

Which cell signaling molecules are involved in ALG3? 09/22/2019

The regulates the expression of glycosylase and the balance of glycosylation reaction by interacting with other glycosylated enzymes such as ALG2 and ALG1.

What is the gene structure and regulation of ALG3? 06/11/2019

ALG3 gene contains 12 exons, and its expression is influenced by multiple regulatory elements and signaling pathways.

Customer Reviews (4)

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Reviews
10/18/2022

    ALG3 has inhibitory or killing effects on specific pathogens.

    08/01/2022

      This protein was found to have high sensitivity and specificity in biosensor preparation.

      06/09/2021

        In drug screening experiments, ALG3 was found to have good selectivity for specific disease-related targets.

        04/30/2021

          ALG3 can promote cell growth and proliferation in cell culture experiments.

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