ALOX5
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Official Full Name
arachidonate 5-lipoxygenase
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Overview
This gene encodes a member of the lipoxygenase gene family and plays a dual role in the synthesis of leukotrienes from arachidonic acid. The encoded protein, which is expressed specifically in bone marrow-derived cells, catalyzes the conversion of arachidonic acid to 5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid, and further to the allylic epoxide 5(S)-trans-7,9-trans-11,14-cis-eicosatetrenoic acid (leukotriene A4). Leukotrienes are important mediators of a number of inflammatory and allergic conditions. Mutations in the promoter region of this gene lead to a diminished response to antileukotriene drugs used in the treatment of asthma and may also be associated with atherosclerosis and several cancers. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined. -
Synonyms
ALOX5; arachidonate 5-lipoxygenase; 5 LOX; leukotriene A4 synthase; arachidonic acid 5-lipoxygenase; arachidonic 5-lipoxygenase alpha-10 isoform; arachidonic 5-lipoxygenase delta-13 isoform; arachidonic 5-lipoxygenase delta-p10 isoform; arachidonic 5-lipo;
- Recombinant Proteins
- Cell & Tissue Lysates
- Antibody
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- E.coli
- E.Coli or Yeast
- HEK293
- HEK293T
- In Vitro Cell Free System
- Insect cell
- Insect Cell
- Mammalian Cell
- Mammalian cells
- S.frugiperda
- Sf21 Insect Cell
- Wheat Germ
- C
- His
- GST
- His (Fc)
- Avi
- MYC
- DDK
- N/A
- N
- Fc
Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
---|---|---|---|---|---|---|
Human | ALOX5-6847H | Recombinant Human ALOX5 protein, His-tagged | E.coli | His | Glu461~Ser671 (Accession # P09917) | |
Human | ALOX5-723H | Recombinant Human Arachidonate 5-lipoxygenase 1 | S.frugiperda | N/A | ||
Human | ALOX5-696H | Recombinant Human Arachidonate 5-lipoxygenase | Sf21 Insect Cell | N/A | ||
Human | ALOX5-578H | Recombinant Human Arachidonate 5-lipoxygenase 1 | Sf21 Insect Cell | N/A | ||
Human | ALOX5-487H | Recombinant Human ALOX5 Protein, GST-tagged | Wheat Germ | GST | ||
Human | ALOX5-8896HCL | Recombinant Human ALOX5 293 Cell Lysate | HEK293 | N/A | ||
Human | ALOX5-0558H | Recombinant Human ALOX5 Protein (Mey1-IIe674), C-His-tagged | Mammalian cells | C-His | Mey1-IIe674 | |
Human | ALOX5-0557H | Recombinant Human ALOX5 Protein (Glu461-Ser671), His-tagged | E.coli | His | Glu461-Ser671 | |
Human | ALOX5-053H | Recombinant Human ALOX5 Protein | Insect cell | 1-674 | ||
Human | ALOX5-120H | Recombinant Human ALOX5 Protein, His-tagged | E.coli | N-His | Met1-Ile674 | |
Human | ALOX5-0559H | Recombinant Human ALOX5 Protein (Full Length), N-Fc-tagged | Mammalian cells | N-Fc | Full Length | |
Human | ALOX5-64H | Recombinant Human ALOX5 Protein | Insect Cell | 1-674 | ||
Human | ALOX5-21HF | Recombinant Full Length Human ALOX5 Protein | In Vitro Cell Free System | 674 amino acids | ||
Human | ALOX5-1481HF | Recombinant Full Length Human ALOX5 Protein, GST-tagged | In Vitro Cell Free System | GST | 674 amino acids | |
Human | ALOX5-26026TH | Recombinant Human ALOX5 | Wheat Germ | N/A | 674 amino acids | |
Mouse | ALOX5-1567M | Recombinant Mouse ALOX5 Protein | Mammalian Cell | His | ||
Mouse | Alox5-6848M | Recombinant Mouse Alox5 protein, His-tagged | E.coli | His | Leu374~Leu536 (Accession # P48999) | |
Mouse | ALOX5-483M | Recombinant Mouse ALOX5 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Mouse | ALOX5-483M-B | Recombinant Mouse ALOX5 Protein Pre-coupled Magnetic Beads | HEK293 | |||
Mouse | Alox5-583M | Recombinant Mouse Alox5 Protein, MYC/DDK-tagged | HEK293T | MYC/DDK | ||
Rat | Alox5-3610R | Recombinant Rat Alox5, His-tagged | E.Coli or Yeast | His | 670 | |
Rat | ALOX5-638R | Recombinant Rat ALOX5 Protein | Mammalian Cell | His | ||
Rat | ALOX5-294R | Recombinant Rat ALOX5 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi | ||
Rat | Alox5-121R | Recombinant Rat Alox5 Protein, His-tagged | E.coli | N-His | Leu373-Leu535 | |
Rat | ALOX5-294R-B | Recombinant Rat ALOX5 Protein Pre-coupled Magnetic Beads | HEK293 |
- Involved Pathway
- Protein Function
- Interacting Protein
- ALOX5 Related Research Area
ALOX5 involved in several pathways and played different roles in them. We selected most pathways ALOX5 participated on our site, such as Arachidonic acid metabolism, Metabolic pathways, Serotonergic synapse, which may be useful for your reference. Also, other proteins which involved in the same pathway with ALOX5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
---|---|
Arachidonic acid metabolism | PTGS2A;CYP2P10;PTGS2B;DPEP2;ALOX12B;GGT1;PLA2G2D;PTGES2;GPX8 |
Metabolic pathways | B4GALT7;TALDO1;PTGS2A;NDUFS8B;CYP3A41B;ST6GAL2A;HPSE2;ALOX15B;SORD |
Serotonergic synapse | ALOX5;HTR1A;GNB3;SLC18A1;PRKACG;CYP2D9;HTR3C;HTR2B;TRPC1 |
Ovarian steroidogenesis | HSD3B4;HSD17B7;GDF9;CYP2J5;PLA2G4D;BMP6;LDLR;PRKACG;PLA2G4F |
Toxoplasmosis | TGFB1;GNAI2;HLA-DPB1;IL10RB;PIK3R5;ALOX5;STAT3;LAMA2;Toxoplasma Gondii Major Surface Antigen P30 |
ALOX5 has several biochemical functions, for example, arachidonate 5-lipoxygenase activity, iron ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ALOX5 itself. We selected most functions ALOX5 had, and list some proteins which have the same functions with ALOX5. You can find most of the proteins on our site.
Function | Related Protein |
---|---|
arachidonate 5-lipoxygenase activity | |
iron ion binding | CYP2C19;NOS1;CYP4F22;CYP3A43;CYP3A4;CYP24A1;CYP4A11;CH25HL2;CYP51A1 |
protein binding | TACR3;ATCAY;COPS2;CITED1;SDHAF2;SF1;VPS45;ANKS4B;ZNF524 |
ALOX5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALOX5 here. Most of them are supplied by our site. Hope this information will be useful for your research of ALOX5.
COTL1; MEOX1; REL; HHIPL2; NUTM1; CEP57L1; SYCE1
- Q&As
- Reviews
Q&As (13)
Ask a questionThe ALOX5 coding gene is located on human chromosome 10.
Currently known ALOX5 inhibitors include trypanosomamine, Ritopane, MK-886, etc., whose mechanism of action is to interfere with the expression or function of ALOX5 in different ways, thereby playing an anti-inflammatory or anti-tumor role.
ALOX5 is involved in a variety of biological processes, including apoptosis, cell proliferation, inflammatory response, and cancer metastasis.
The gene expression can be regulated by a variety of factors such as prostaglandins, cytokines and interferons.
Some foods rich in polyphenols, such as cucumbers, tomatoes, grapes, green tea, etc., are thought to inhibit ALOX5 activity.
In general, the ALOX5 gene is highly expressed in eosinophils and monocytes.
The ALOX5 promoter region is the starting point of gene transcription and is responsible for mediating the transcription regulation of the ALOX5 gene.
Drugs that block the ALOX5 signaling pathway, such as Zileuton, MK886, and A861, have been shown to inhibit tumor cell proliferation and invasion. Currently, there are also many researchers who are exploring ALOX5 in tumors.
ALOX5 gene mutation may cause asthma, allergic rhinitis, eczema and other allergic diseases.
5-HETE is one of the representative products of ALOX5 catalyzed synthesis, and is an activator of platelets and neutrophils.
There is no definite answer to this question. Current studies believe that ALOX5 can affect the occurrence, development and metastasis of tumors through multiple ways, including regulating the proliferation, apoptosis, invasion and metastasis of tumor cells.
ALOX5 knockout mouse models can be used to study a variety of biological processes and diseases, such as immune regulation, inflammation, asthma, eczema, autoimmunity, etc.
At present, the commonly used methods include real-time fluorescent quantitative PCR, Northern blot, Western blot, etc.
Customer Reviews (3)
Write a reviewAfter ALOX5 application, the background of the Western blot was very clean with no nonspecific signal.
ALOX5 significantly improved the experimental accuracy and made the experimental results more reliable.
I appreciate the stability of ALOX5, which can be kept at room temperature for several days without spoilage.
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