ALX1
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Official Full Name
ALX homeobox 1
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Overview
The specific function of this gene has yet to be determined in humans; however, in rodents, it is necessary for;survival of the forebrain mesenchyme and may also be involved in development of the cervix. Mutations in the mouse;gene lead to neural tube defects such as acrania and meroanencephaly. -
Synonyms
ALX1; ALX homeobox 1; CART1, cartilage paired class homeoprotein 1; ALX homeobox protein 1; ALX1_HUMAN; CART 1; CART-1; CART1; Cartilage homeoprotein 1; OTTHUMP00000242207; cartilage paired-class homeoprotein 1; FND3;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Zebrafish
- E.coli
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- GST|His
- His
- His (Fc)
- Avi
- N/A
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | ALX1-9604H | Recombinant Human ALX1, His-tagged | E.coli | His | 1-326a.a. | |
| Human | ALX1-0012H | Recombinant Human ALX1 Protein, GST-Tagged | Wheat Germ | GST |
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| Human | ALX1-037H | Recombinant Human ALX1 Protein, GST-HIS-tagged | E.coli | GST/His |
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| Human | ALX1-8890HCL | Recombinant Human ALX1 293 Cell Lysate | HEK293 | N/A |
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| Human | ALX1-2596HF | Recombinant Full Length Human ALX1 Protein, GST-tagged | In Vitro Cell Free System | GST | 326 amino acids |
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| Mouse | ALX1-1581M | Recombinant Mouse ALX1 Protein | Mammalian Cell | His |
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| Mouse | ALX1-494M | Recombinant Mouse ALX1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Mouse | ALX1-494M-B | Recombinant Mouse ALX1 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Zebrafish | ALX1-4127Z | Recombinant Zebrafish ALX1 | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
ALX1 involved in several pathways and played different roles in them. We selected most pathways ALX1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with ALX1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
ALX1 has several biochemical functions, for example, RNA polymerase II regulatory region sequence-specific DNA binding, protein binding, protein heterodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ALX1 itself. We selected most functions ALX1 had, and list some proteins which have the same functions with ALX1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA polymerase II regulatory region sequence-specific DNA binding | RXRB;LEF1;BHLHA15;STAT4;GLIS1;DMRT1;ZNF548;PRDM12B;FOXF1 |
| protein binding | LXN;PSMC1;ZNF148;HGF;ADPRH;TBC1D20;PYGB;NGFRB;HESX1 |
| protein heterodimerization activity | BAX;NFYB;ATF4;TTR;DRAP1;SLC51B;SNX6;CXCL13;MID2 |
| protein homodimerization activity | ABCG2;GSTA4;RABEP1;TYW5;UBE4A;NR4A2;ERBB4;BIRC5;SLC16A1 |
| transcription corepressor activity | SKI;ARHGAP35;YY1;AJUBA;HDAC7;ERF;PFDN5;JUNB;CTBP2A |
| transcription factor activity, sequence-specific DNA binding | TEFB;PRDM2;HELT;ZFP639;ALX1;GABPB1;E2F3;IRF1B;BACH2 |
| transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding | HOXD8;MAFG;TRP53;PLAGL1;FEZF2;GRHL2;PAX9;SOX17;LMO2 |
ALX1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ALX1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ALX1.
IPO13
- Q&As
- Reviews
Q&As (10)
Ask a questionALX1 can be targeted using small molecules, CRISPR/Cas9-based gene editing, or other techniques to modulate its expression or activity, offering potential therapeutic approaches for craniofacial disorders.
ALX1 integrates with signaling pathways such as BMP, Wnt, or FGF signaling to regulate gene expression and cellular behaviors involved in craniofacial development.
ALX1 exhibits dynamic spatial and temporal expression patterns during embryonic development, with specific regulation by signaling pathways, transcription factors, or tissue-specific cues.
ALX1 plays a crucial role in the maintenance and differentiation of cranial neural crest cells, influencing their migration, proliferation, and specification into various craniofacial tissues.
ALX1 interacts with co-regulatory proteins or other transcription factors, forming complexes that modulate gene expression and cellular processes critical for craniofacial morphogenesis.
ALX1 regulates the expression of genes involved in craniofacial development, including those encoding transcription factors, extracellular matrix components, or signaling molecules.
Genetic variations or mutations in ALX1 can disrupt its DNA-binding ability, protein-protein interactions, or transcriptional activity, leading to craniofacial abnormalities or related disorders.
Determining the three-dimensional structure of ALX1 provides insights into its DNA-binding specificity, transcriptional activation domains, and interaction surfaces.
ALX1 regulates downstream effectors or signaling pathways, including those involved in osteogenesis, chondrogenesis, or epithelial-mesenchymal interactions critical for craniofacial morphogenesis.
Studying ALX1 dysfunction in animal models provides insights into the cellular and molecular mechanisms underlying craniofacial malformations, including altered cell migration, proliferation, or differentiation.
Customer Reviews (3)
Write a reviewWide range of available antibody formats for versatility.
Precise quantification of protein-protein interaction affinity.
Time-saving assay procedures without compromising accuracy.
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