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Recombinant Human ALX1 Protein, GST-HIS-tagged

Cat.No. : ALX1-037H
Product Overview : Recombinant Human ALX1 fused with N-terminal GST and C-terminal His was expressed in E. coli.
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  • Gene Information
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Description : The specific function of this gene has yet to be determined in humans; however, in rodents, it is necessary for survival of the forebrain mesenchyme and may also be involved in development of the cervix. Mutations in the mouse gene lead to neural tube defects such as acrania and meroanencephaly.
Source : E. coli
Species : Human
Tag : GST-HIS
Form : 25mM Tris, pH8.0,150mM NaCl,10% glycerol,1% Sarkosyl.
Molecular Mass : 62.8 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration : >50 ug/mL as determined by microplate BCA method
Gene Name : ALX1 ALX homeobox 1 [ Homo sapiens ]
Official Symbol : ALX1
Synonyms : ALX1; ALX homeobox 1; CART1, cartilage paired class homeoprotein 1; ALX homeobox protein 1; CART-1; cartilage paired-class homeoprotein 1; FND3; CART1;
Gene ID : 8092
mRNA Refseq : NM_006982
Protein Refseq : NP_008913
MIM : 601527
UniProt ID : Q15699

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (10)

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Can ALX1 be targeted with small molecules or gene editing technologies to modulate its activity or expression, and what are the potential therapeutic applications? 03/05/2022

ALX1 can be targeted using small molecules, CRISPR/Cas9-based gene editing, or other techniques to modulate its expression or activity, offering potential therapeutic approaches for craniofacial disorders.

How does ALX1 modulate signaling pathways involved in craniofacial development, such as BMP, Wnt, or FGF signaling? 04/05/2021

ALX1 integrates with signaling pathways such as BMP, Wnt, or FGF signaling to regulate gene expression and cellular behaviors involved in craniofacial development.

What is the spatial and temporal expression pattern of ALX1 during embryonic development, and how is its expression regulated? 02/04/2021

ALX1 exhibits dynamic spatial and temporal expression patterns during embryonic development, with specific regulation by signaling pathways, transcription factors, or tissue-specific cues.

What is the role of ALX1 in the maintenance and differentiation of cranial neural crest cells, and how does it impact their migratory behavior and fate determination? 07/21/2020

ALX1 plays a crucial role in the maintenance and differentiation of cranial neural crest cells, influencing their migration, proliferation, and specification into various craniofacial tissues.

How does ALX1 interact with other transcription factors or co-regulators to form regulatory complexes, and what are the functional consequences of these interactions? 05/27/2020

ALX1 interacts with co-regulatory proteins or other transcription factors, forming complexes that modulate gene expression and cellular processes critical for craniofacial morphogenesis.

What are the transcriptional targets of ALX1, and how does it regulate gene expression during craniofacial development or other relevant processes? 04/09/2020

ALX1 regulates the expression of genes involved in craniofacial development, including those encoding transcription factors, extracellular matrix components, or signaling molecules.

How do genetic variations or mutations in ALX1 impact its function and contribute to craniofacial abnormalities or other related disorders? 12/21/2019

Genetic variations or mutations in ALX1 can disrupt its DNA-binding ability, protein-protein interactions, or transcriptional activity, leading to craniofacial abnormalities or related disorders.

Can the three-dimensional structure of ALX1 be determined to gain insights into its DNA-binding specificity and protein-protein interaction interfaces? 03/31/2018

Determining the three-dimensional structure of ALX1 provides insights into its DNA-binding specificity, transcriptional activation domains, and interaction surfaces.

What are the downstream effectors or signaling pathways regulated by ALX1, and how do they contribute to craniofacial morphogenesis or tissue-specific processes? 06/24/2017

ALX1 regulates downstream effectors or signaling pathways, including those involved in osteogenesis, chondrogenesis, or epithelial-mesenchymal interactions critical for craniofacial morphogenesis.

How does ALX1 dysfunction affect craniofacial development in animal models, and what are the cellular and molecular mechanisms underlying these phenotypic alterations? 03/21/2017

Studying ALX1 dysfunction in animal models provides insights into the cellular and molecular mechanisms underlying craniofacial malformations, including altered cell migration, proliferation, or differentiation.

Customer Reviews (3)

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Reviews
03/27/2021

    Wide range of available antibody formats for versatility.

    05/18/2020

      Precise quantification of protein-protein interaction affinity.

      11/03/2017

        Time-saving assay procedures without compromising accuracy.

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