anxa2
Share
  • Official Full Name
  • annexin A2
  • Background
  • This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. This gene has three pseudogenes located on chromosomes 4, 9 and 10, respectively. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • ANXA2; annexin A2; ANX2ANX2L4; CAL1H; LPC2D; LIP2; Annexin II; Annexin-2; Calpactin I heavy chain; Calpactin-1 heavy chain; Chromobindin-8; Lipocortin II; Placental anticoagulant protein IV; PAP-IV; Protein I; p36; LPC2; chromobindin 8; OTTHUMP00000163650; calpactin I heavy polypeptide
Cat.#:ANXA2-26598THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ANXA2, His-tagged
+Inquiry
Cat.#:ANXA2-1846HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ANXA2 protein
+Inquiry
Cat.#:ANXA2-631HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ANXA2 protein, GST-tagged
+Inquiry
Cat.#:ANXA2-9695HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ANXA2, GST-tagged
+Inquiry
Cat.#:ANXA2-1714MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ANXA2 Protein
+Inquiry
Cat.#:Anxa2-3494MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse Anxa2, His-tagged
+Inquiry
Cat.#:Anxa2-3495MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Anxa2 protein, His/T7-tagged
+Inquiry
Cat.#:ANXA2-689RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat ANXA2 Protein
+Inquiry
Cat.#:ANXA2-6903CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken ANXA2
+Inquiry
Cat.#:ANXA2-5278HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Annexin A2, His-tagged
+Inquiry
Cat.#:ANXA2-1845HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Annexin A2, His-tagged
+Inquiry
Cat.#:ANXA2-8833HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human ANXA2 293 Cell Lysate
+Inquiry
Cat.#:ANXA2-8834HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human ANXA2 293 Cell Lysate
+Inquiry

Involved Pathway

ANXA2 involved in several pathways and played different roles in them. We selected most pathways ANXA2 participated on our site, such as Dissolution of Fibrin Clot, Hemostasis, Muscle contraction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ANXA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Dissolution of Fibrin Clot
S100A10A; ANXA2A; SERPINF2B; HRG; ANXA2B; SERPINB8; S100A10B; S100A10; SERPINE2; ANXA2
Hemostasis
DGKB; RAPGEF4; F3B; ABHD12; RACGAP1; C6orf25; TRPC6A; KIFC1; PROCA; STXBP3A
Muscle contraction
TMOD4; SORBS3; MYL12A; TNNI2B.1; LMOD1; TNNI2B.2; TNNT3A; DESMA; DES; MYLZ3
Prostaglandin Synthesis and Regulation
CC10; ANXA4; ANXA5; S100A10; ANXA6; ANXA3; ANXA2; S100A6

Protein Function

ANXA2 has several biochemical functions, for example, Rab GTPase binding, S100 protein binding, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ANXA2 itself. We selected most functions ANXA2 had, and list some proteins which have the same functions with ANXA2. You can find most of the proteins on our site.
Function
Related Protein
Function Rab GTPase binding
Related Protein RAB11FIP1; SGSM2; RAB11FIP3; CFAP45; RIN3; SYTL1; ZFP652; DENND5A; PIFO; MLPHB
Function S100 protein binding
Related Protein ATP2A2; S100A6; AHNAK; ANXA11; FGF1; S100B; AGER; FGF1A; EZR; ANXA2
Function calcium ion binding
Related Protein FKBP7; C1R; AIF1; BGLAP; SYT3; SYTL4; PCDH2G29; EFHD1; ESYT2; PCDH2G8
Function calcium-dependent phospholipid binding
Related Protein SYT5; ANXA7; ANXA6; SYT17; ANXA13; ANXA11B; ANXA2B; CCDC167; CPNE1; SYT9
Function calcium-dependent protein binding
Related Protein VLDLR; SYN1; STX1A; ANXA1; CCDC167; RBM22; DDX5; S100A4; TNNT3; ALG2
Function cytoskeletal protein binding
Related Protein EZRB; EPB41L5; EPB41L3B; ANXA2A; EPB41L3A; MYLIP; LDB3; ANXA2B; SLC8A1; CAPN2
Function phosphatidylinositol-4,5-bisphosphate binding
Related Protein KLHL8; FAM123B; FRMPD4; RPH3A; TULP1; PFN1; Apba1; TWF2; ADAP2; RS1
Function phospholipase A2 inhibitor activity
Related Protein ANXA3; ANXA1; ANXA2; CC10
Function poly(A) RNA binding
Related Protein NAP1L4; TAF15; MKI67IP; AGO2; LARP2; RPL6; EIF3I; TDRD9; HSPE1; FASTKD5
Function protease binding
Related Protein MBL1; Serpina1c; CSTA; ANXA2; NDUFS7; SERPINA1; C10orf2; NFRKB; POLG; CCBE1
Function protein binding
Related Protein ODF1; PER2; SH2D4A; TXK; CTNNA1; SLC39A7; PTPN14; SPERT; ITGB3BP; TTC8
Function contributes_to receptor activator activity
Related Protein ANXA2

Interacting Protein

ANXA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ANXA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of ANXA2.
PCSK9; MLH1; q99ib8-pro_0000045602; ns3_ns4a_hcvco

ANXA2 Related Articles

Canas, F; Simonin, L; et al. Annexin A2 autoantibodies in thrombosis and autoimmune diseases. THROMBOSIS RESEARCH 135:226-230(2015).
Chaudhary, P; Thamake, SI; et al. Inhibition of triple-negative and Herceptin-resistant breast cancer cell proliferation and migration by Annexin A2 antibodies. BRITISH JOURNAL OF CANCER 111:2328-2341(2014).