aoc2
Share
  • Official Full Name
  • amine oxidase, copper containing 2 (retina-specific)
  • Background
  • Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes and ammonia in the presence of copper and quinone cofactor. This gene shows high sequence similarity to copper amine oxidases from various species ranging from bacteria to mammals. The protein contains several conserved motifs including the active site of amine oxidases and the histidine residues that likely bind copper. It may be a critical modulator of signal transmission in retina, possibly by degrading the biogenic amines dopamine, histamine, and putrescine. This gene may be a candidate gene for hereditary ocular diseases. Alternate splicing results in multiple transcript variants.
  • Synonyms
  • AOC2; amine oxidase, copper containing 2 (retina-specific); retina-specific copper amine oxidase; DAO2; RAO; Amine oxidase [copper containing]; Amine oxidase copper containing 2 (retina specific); Amine oxidase copper containing 2; Retina specific copper amine oxidase; SSAO; semicarbazide-sensitive amine oxidase
Cat.#:AOC2-640HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human AOC2 protein, GST-tagged
+Inquiry
Cat.#:AOC2-9704HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human AOC2, His-tagged
+Inquiry
Cat.#:AOC2-1723MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse AOC2 Protein
+Inquiry
Cat.#:AOC2-2213ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish AOC2
+Inquiry
Cat.#:AOC2-8822HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human AOC2 293 Cell Lysate
+Inquiry
Cat.#:AOC2-8823HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human AOC2 293 Cell Lysate
+Inquiry

Involved Pathway

AOC2 involved in several pathways and played different roles in them. We selected most pathways AOC2 participated on our site, such as Glycine, serine and threonine metabolism, Tyrosine metabolism, Phenylalanine metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with AOC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Glycine, serine and threonine metabolism
CBSB; THA1; DAO.3; DAO.1; ALDH7A1; PGAM1; MAOB; DLDH; PIPOX; AOC2
Tyrosine metabolism
ALDH3B2; PNMT; GOT2B; ADH1; AOC3; GOT2A; TPO; TYR; ALDH3B1; AOX3L1
Phenylalanine metabolism
GOT2; GOT2B; ALDH1A3; HPD; ALDH3A1; KEG1; GOT2A; HPDB; PAH; MIF
beta-Alanine metabolism
ALDH6A1; ALDH1B1; ALDH3A1; SMOX; ALDH2.1; DPYDB; ALDH7A1; ALDH9A1; HIBCH; AOC2
Metabolic pathways
POLR2EB; PTGDS; SGSH; PDHX; ADKA; B3GALT2; CYP11B1; AMPD2; CYP3A41B; ALDH1B1

Protein Function

AOC2 has several biochemical functions, for example, aliphatic-amine oxidase activity, aminoacetone:oxygen oxidoreductase(deaminating) activity, copper ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by AOC2 itself. We selected most functions AOC2 had, and list some proteins which have the same functions with AOC2. You can find most of the proteins on our site.
Function
Related Protein
Function aliphatic-amine oxidase activity
Related Protein AOC3; AOC2
Function aminoacetone:oxygen oxidoreductase(deaminating) activity
Related Protein AOC3; AOC2
Function copper ion binding
Related Protein AOC3; SOD3A; LOXL2; DBH; HEPH; PRNPA; TYR; PRNP; LOXL5A; PARK7
Function electron carrier activity
Related Protein AKR7A2; CIAPIN1; AKR1A1; DHDH; ALDH4A1; SDHB; GPX2; GSR; SDHC; GLRX3
Function phenethylamine:oxygen oxidoreductase (deaminating) activity
Related Protein AOC2; AOC3
Function primary amine oxidase activity
Related Protein AOC2; MAOA; AOC3; MAOB; AOC1; VCAM1; ABP1
Function quinone binding
Related Protein SQRDL; VKORC1L1; HHIPL1; TP53I3; HHIP; AOC3; NDUFS2; ETFDH; ABP1; AMOTL1
Function tryptamine:oxygen oxidoreductase (deaminating) activity
Related Protein AOC2; AOC3

AOC2 Related Articles

Imamura, Y; Kubota, R; et al. Human retina-specific amine oxidase (RAO): cDNA cloning, tissue expression, and chromosomal mapping. GENOMICS 40:277-283(1997).