Recombinant Human AOC2 protein, GST-tagged

• Cat.No.: AOC2-640H
• Product Overview: Human AOC2 full-length ORF ( NP_033720.2, 1 a.a. - 756 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes and ammonia in the presence of copper and quinone cofactor. This gene shows high sequence similarity to copper amine oxidases from various species ranging from bacteria to mammals. The protein contains several conserved motifs including the active site of amine oxidases and the histidine residues that likely bind copper. It may be a critical modulator of signal transmission in retina, possibly by degrading the biogenic amines dopamine, histamine, and putrescine. This gene may be a candidate gene for hereditary ocular diseases. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 110.1 kDa
• AA Sequence: MHLKIVLAFLALSLITIFALAYVLL TSPGGSSQPPHCPSVSHRAQPWPHP GQSQLFADLSREELTAVMRFLTQRL GPGLVDAAQAQPSDNCIFSVELQLP PKAAALAHLDRGSPPPAREALAIVL FGGQPQPNVSELVVGPLPHPSYMRD VTVERHGGPLPYHRRPVLRAEFTQM WRHLKEVELPKAPIFLSSTFNYNGS TLAAVHATPRGLRSGDRATWMALYH NISGVGLFLHPVGLELLLDHRALDP AHWTVQQVFYLGHYYADLGQLEREF KSGRLEVVRVPLPPPNGASSLRSRN SPGPLPPLQFSPQGSQYSVQGNLVV SSLWSFTFGHGVFSGLRIFDVRFQG ERIAYEVSVQECVSIYGADSPKTML TRYLDSSFGLGRNSRGLVRGVDCPY QATMVDIHILVGKGAVQLLPGAVCV FEEAQGLPLRRHHNYLQNHFYGGLA SSALVVRSVSSVGNYDYIWDFVLYP NGALEGRVHATGYINTAFLKGGEEG LLFGNRVGERVLGTVHTHAFHFKLD LDVAGLKNWVVAEDVVFKPVAAPWN PEHWLQRPQLTRQVLGKEDLTAFSL GSPLPRYLYLASNQTNAWGHQRGYR IQIHSPLGIHIPLESDMERALSWGR YQLVVTQRKEEESQSSSIYHQNDIW TPTVTFADFINNETLLGEDLVAWVT ASFLHIPHAEDIPNTVTLGNRVGFL LRPYNFFDEDPSIFSPGSVYFEKGQ DAGLCSINPVACLPDLAACVPDLPP FSYHGF
• Applications: Enzyme-linked Immunoabsorbent Assay; Western Blot (Recombinant protein); Antibody Production; Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: AOC2 amine oxidase, copper containing 2 (retina-specific) [ Homo sapiens ]
• Official Symbol: AOC2
• Synonyms: AOC2; amine oxidase, copper containing 2 (retina-specific); retina-specific copper amine oxidase; DAO2; RAO; SSAO; semicarbazide-sensitive amine oxidase
• Gene ID: 314
• mRNA Refseq: NM_001158
• Protein Refseq: NP_001149
• MIM: 602268
• UniProt ID: O75106