AOX1
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Official Full Name
aldehyde oxidase 1
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Overview
Aldehyde oxidase produces hydrogen peroxide and, under certain conditions, can catalyze the formation of superoxide. Aldehyde oxidase is a candidate gene for amyotrophic lateral sclerosis. -
Synonyms
AOX1; aldehyde oxidase 1; aldehyde oxidase; AO; AOH1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Cynomolgus Monkey
- Human
- Mouse
- Nicotiana tabacum (Common tobacco)
- Podospora anserina (Pleurage anserina)
- Rat
- Rhesus Macaque
- Sauromatum venosum (Voodoo lily) (Typhonium venosum)
- Zebrafish
- E. coli
- E.coli
- E.coli expression system
- E.Coli or Yeast
- HEK293
- HEK293T
- Mamanlian cells
- Mammalian Cell
- Flag
- His
- His (Fc)
- Avi
- Myc
- DDK
- MYC
- Myc|DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- AOX1 Related Articles
- AOX1 Related Research Area
- AOX1 Related Signal Pathway
AOX1 involved in several pathways and played different roles in them. We selected most pathways AOX1 participated on our site, such as Valine, leucine and isoleucine degradation, Tyrosine metabolism, Tryptophan metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with AOX1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Valine, leucine and isoleucine degradation | IL4I1;OXCT1A;HADHAB;DLDH;OXCT2A;ALDH3A2;ALDH3A2A;ALDH2;MCCC2 |
| Tyrosine metabolism | HGD;IL4I1;ALDH1A3;ADH1;ALDH3B1;ADH2-1;TPO;AOX2P;HPDA |
| Tryptophan metabolism | TPH1A;INMT;MAOB;OGDHA;ALDH3A2;AOX3;OGDH;ANI_1_2390104;CAT |
| Vitamin B metabolism | AOX4;PSAT1;PNPO;AOX3L1;PDXKA;AOX3;PDXP;PHOSPHO2;AOX2P |
| Nicotinate and nicotinamide metabolism | ITGB1BP3;QPRT;NT5C3L;NADSYN1;NUDT12;MIBP;NAMPTB;NT5C3A;NADKD1 |
| Retinol metabolism | BCO1L;CYP3A41A;RDH10A;CYP2C39;RDH11;RDH8B;RDH10B;AOX3L1;UGT1A3 |
| Drug metabolism - cytochrome P | GSTA4;UGT2A1;FMO6P;UGT1A6;FMO5;UGT1A2;GSTM7;UGT1A7C;UGT1A9 |
| Metabolic pathways | ATP5I;PLA2G6;B4GALT6;ITPA;DCXR;AANAT1;PCK2;DPYDB;AGPAT4 |
| Jak-STAT signaling pathway | IL22RA1;Gh;STAM2;CCND1;IL11;GFAP;IL24;IL23;IL21 |
AOX1 has several biochemical functions, for example, 2 iron, 2 sulfur cluster binding, NAD binding, aldehyde oxidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by AOX1 itself. We selected most functions AOX1 had, and list some proteins which have the same functions with AOX1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| 2 iron, 2 sulfur cluster binding | CISD2;AIFM4;GLRX5;AOX1;ISCA1;FDX1B;RFESD;NDUFV2;FDX1 |
| NAD binding | GRHPRB;AHCY;NDUFS2;AOX1;GPD1C;ME2;ME3;TESCA;HIBADH |
| aldehyde oxidase activity | ADH7;AOX4;AOX1;AOX3L1;AOX3 |
| electron carrier activity | GCDHB;GLDC;AOC2;ACOX1;SDHB;ME1;COX7A1;AOX3;IVD |
| flavin adenine dinucleotide binding | ACADVL;TXNRD3;NOX5;ACADS;AIFM3;CHDH;IVD;GSR;NOX4 |
| iron ion binding | HBAE1;HBAA1;CYP2K19;C14orf169;CYP2A6;CYP11B2;CYP2F2;NOS2A;FAM125B |
| molybdopterin cofactor binding | AOX1;SUOX;MOSC2;MARC2;MARC1;XDH |
| oxidoreductase activity, acting on CH-OH group of donors | GULO;XDH;AOX4;AOX1;AOX3;AOX3L1;DHCR24;AGPS |
| xanthine dehydrogenase activity | AOX1;XDH |
AOX1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with AOX1 here. Most of them are supplied by our site. Hope this information will be useful for your research of AOX1.
RBL1; GK; CRKL; RCHY1
- Q&As
- Reviews
Q&As (20)
Ask a questionAOX1 can play anti-inflammatory, antioxidant and immunomodulatory roles in the body, and can produce therapeutic effects on many diseases.
AOX1 can reduce the body's inflammatory response, reduce the risk of infection, etc., is an effective anti-inflammatory drug.
The quality control of AOX1 includes process control in the production process, evaluation of product quality characteristics and physical and chemical properties.
AOX1 is used in basic research, such as cardiovascular diseases, immune system diseases, diabetes and other related research.
AOX1 has been carried out a number of clinical trials, in the treatment of different diseases have achieved good efficacy.
Recombinant AOX1 protein can coordinate the metabolism of oxygen free radicals and trans-lipid peroxides in the body, thereby reducing the risk of cardiovascular disease.
The AOX1 fermentation process needs to be optimized for mass transfer, metabolism and expression to improve yield and quality.
AOX1 has the advantages of high safety and stable effect in the research and development of new drugs.
The AOX1 has a molecular weight of about 38kDa and is characterized by a cofactor FAD, which shows monoglycine dehydrogenase activity in this linked molecule.
AOX1 can be stably preserved at 4 degrees of refrigeration, and long-term storage needs to be stored at an ultra-low temperature environment of -80 degrees.
AOX1 is an immunomodulatory protein that can produce therapeutic effects on autoimmune diseases such as lupus erythematosus.
AOX1 can be used in the treatment of cardiovascular diseases, lupus erythematosus, autoimmune diseases and other diseases.
The therapeutic effect of AOX1 has a certain persistence, and the treatment regimen can be adjusted according to the patient's condition.
As a biomedical product, AOX1 has broad clinical application prospects in cardiovascular diseases, immune system diseases, metabolic diseases and other fields.
The dosage and use method of AOX1 need to be guided by the doctor according to the specific disease and patient situation.
AOX1 can help reduce blood sugar, improve insulin resistance, etc., so as to have a therapeutic effect on diabetes.
The production process of AOX1 includes gene cloning, fermentation, purification and other steps. Generally, E. coli expression system and mammalian cell expression system are used.
AOX1 spectral analysis can help researchers study protein structure and properties, explore its mechanism of action in biological and medical research, and provide an important reference for subsequent research.
As a biomedical product, AOX1 needs to be strictly evaluated for safety in clinical application to ensure its safety.
AOX1 is often purified by affinity chromatography, ion exchange chromatography, gel filtration and other methods.
Customer Reviews (4)
Write a reviewUsing AOX1 can reduce the error in the experiment.
Preserving its stability under extreme conditions, such as at high or low temperatures, is very advantageous for us to conduct experiments.
Catalytic activity is very strong, which can significantly improve the selectivity and yield of chemical reactions, and has high application value.
After using this recombinant protein, the lower limit of Western blot detection is greatly reduced.
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