Recombinant Human AOX1 Protein (236-421 aa), His-tagged
Cat.No. : | AOX1-329H |
Product Overview : | Recombinant Human AOX1 Protein (236-421 aa) is produced by E. coli expression system. This protein is fused with a 6xHis tag at the N-terminal. Research Area: Metabolismn. Protein Description: Partial. |
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Description : | Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide and N-methylphthalazinium, as well as aldehydes, such as benzaldehyde, retinal, pyridoxal, and vanillin. Plays a key role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Participates in the bioactivation of prodrugs such as famciclovir, catalyzing the oxidation step from 6-deoxypenciclovir to penciclovir, which is a potent antiviral agent. Is probably involved in the regulation of reactive oxygen species homeostasis. May be a prominent source of superoxide generation via the one-electron reduction of molecular oxygen. Also may catalyze nitric oxide (NO) production via the reduction of nitrite to NO with NADH or aldehyde as electron donor. May play a role in adipogenesis |
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | Tris-based buffer, 50% glycerol |
Molecular Mass : | 24.6 kDa |
Protein length : | 236-421 aa |
AA Sequence : | FGSERMMWFSPVTLKELLEFKFKYP QAPVIMGNTSVGPEVKFKGVFHPVI ISPDRIEELSVVNHAYNGLTLGAGL SLAQVKDILADVVQKLPEEKTQMYH ALLKHLGTLAGSQIRNMASLGGHII SRHPDSDLNPILAVGNCTLNLLSKE GKRQIPLNEQFLSKCPNADLKPQEI LVSVNIPYSRK |
Purity : | > 90% as determined by SDS-PAGE. |
Notes : | Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week. |
Storage : | The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade. |
Concentration : | A hardcopy of COA with concentration instruction is sent along with the products. |
Gene Name : | AOX1 aldehyde oxidase 1 [ Homo sapiens ] |
Official Symbol : | AOX1 |
Synonyms : | AOX1; aldehyde oxidase 1; aldehyde oxidase; AO; AOH1; |
Gene ID : | 316 |
mRNA Refseq : | NM_001159 |
Protein Refseq : | NP_001150 |
MIM : | 602841 |
UniProt ID : | Q06278 |
Products Types
◆ Recombinant Protein | ||
Aox1-617M | Recombinant Mouse Aox1 Protein, MYC/DDK-tagged | +Inquiry |
AOX1-110H | Active Recombinant Human AOX1 Protein | +Inquiry |
AOX1-169R | Recombinant Rhesus Macaque AOX1 Protein, His (Fc)-Avi-tagged | +Inquiry |
AOX1-50C | Recombinant Cynomolgus Monkey AOX1 Protein, His (Fc)-Avi-tagged | +Inquiry |
AOX1-350R | Recombinant Rat AOX1 Protein, His (Fc)-Avi-tagged | +Inquiry |
◆ Lysates | ||
AOX1-8821HCL | Recombinant Human AOX1 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (20)
Ask a questionAOX1 can play anti-inflammatory, antioxidant and immunomodulatory roles in the body, and can produce therapeutic effects on many diseases.
AOX1 can reduce the body's inflammatory response, reduce the risk of infection, etc., is an effective anti-inflammatory drug.
The quality control of AOX1 includes process control in the production process, evaluation of product quality characteristics and physical and chemical properties.
AOX1 is used in basic research, such as cardiovascular diseases, immune system diseases, diabetes and other related research.
AOX1 has been carried out a number of clinical trials, in the treatment of different diseases have achieved good efficacy.
Recombinant AOX1 protein can coordinate the metabolism of oxygen free radicals and trans-lipid peroxides in the body, thereby reducing the risk of cardiovascular disease.
The AOX1 fermentation process needs to be optimized for mass transfer, metabolism and expression to improve yield and quality.
AOX1 has the advantages of high safety and stable effect in the research and development of new drugs.
The AOX1 has a molecular weight of about 38kDa and is characterized by a cofactor FAD, which shows monoglycine dehydrogenase activity in this linked molecule.
AOX1 can be stably preserved at 4 degrees of refrigeration, and long-term storage needs to be stored at an ultra-low temperature environment of -80 degrees.
AOX1 is an immunomodulatory protein that can produce therapeutic effects on autoimmune diseases such as lupus erythematosus.
AOX1 can be used in the treatment of cardiovascular diseases, lupus erythematosus, autoimmune diseases and other diseases.
The therapeutic effect of AOX1 has a certain persistence, and the treatment regimen can be adjusted according to the patient's condition.
As a biomedical product, AOX1 has broad clinical application prospects in cardiovascular diseases, immune system diseases, metabolic diseases and other fields.
The dosage and use method of AOX1 need to be guided by the doctor according to the specific disease and patient situation.
AOX1 can help reduce blood sugar, improve insulin resistance, etc., so as to have a therapeutic effect on diabetes.
The production process of AOX1 includes gene cloning, fermentation, purification and other steps. Generally, E. coli expression system and mammalian cell expression system are used.
AOX1 spectral analysis can help researchers study protein structure and properties, explore its mechanism of action in biological and medical research, and provide an important reference for subsequent research.
As a biomedical product, AOX1 needs to be strictly evaluated for safety in clinical application to ensure its safety.
AOX1 is often purified by affinity chromatography, ion exchange chromatography, gel filtration and other methods.
Customer Reviews (4)
Write a reviewUsing AOX1 can reduce the error in the experiment.
Preserving its stability under extreme conditions, such as at high or low temperatures, is very advantageous for us to conduct experiments.
Catalytic activity is very strong, which can significantly improve the selectivity and yield of chemical reactions, and has high application value.
After using this recombinant protein, the lower limit of Western blot detection is greatly reduced.
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