arf1
Share
  • Official Full Name
  • ADP-ribosylation factor 1
  • Background
  • ADP-ribosylation factor 1 (ARF1) is a member of the human ARF gene family. The family members encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking as activators of phospholipase D. The gene products, including 6 ARF proteins and 11 ARF-like proteins, constitute a family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1, ARF2 and ARF3), class II (ARF4 and ARF5) and class III (ARF6), and members of each class share a common gene organization. The ARF1 protein is localized to the Golgi apparatus and has a central role in intra-Golgi transport. Multiple alternatively spliced transcript variants encoding the same protein have been found for this gene.
  • Synonyms
  • ARF1; ADP-ribosylation factor 1
Cat.#:ARF1-224HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ARF1, His-tagged
+Inquiry
Cat.#:ARF1-744HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ARF1 protein, GST-tagged
+Inquiry
Cat.#:ARF1-9799HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ARF1, GST-tagged
+Inquiry
Cat.#:ARF1-1837MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ARF1 Protein
+Inquiry
Cat.#:Arf1-3205RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat Arf1, His-tagged
+Inquiry
Cat.#:ARF1-747RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat ARF1 Protein
+Inquiry
Cat.#:ARF1-308CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus ARF1 Protein, His-tagged
+Inquiry
Cat.#:ARF1-378RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey ARF1 Protein, His-tagged
+Inquiry
Cat.#:ARF1-1496CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken ARF1
+Inquiry
Cat.#:ARF1-11499ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish ARF1
+Inquiry
Cat.#:ARF1-2769HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human ADP-ribosylation Factor 1, His-tagged
+Inquiry
Cat.#:ARF1-8760HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human ARF1 293 Cell Lysate
+Inquiry
Cat.#:ARF1-8761HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human ARF1 293 Cell Lysate
+Inquiry

Involved Pathway

ARF1 involved in several pathways and played different roles in them. We selected most pathways ARF1 participated on our site, such as Adaptive Immune System, Arf1 pathway, Arf6 downstream pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Adaptive Immune System
SIGLEC10; RNF123; UBE2L6; PDPK1A; CD200R3; FBXO44; Siglece; CHUK; DNM2; MOV10
Arf1 pathway
ARF1; AP2A1; ARFIP2; CLTA; CLTB; AP2M1; USO1
Arf6 downstream pathway
ARF1
COPI Mediated Transport
COPE; COPZ1; COPG; COPB2; ARCN1A; COPB1; ARCN1; ARCN1B; ARF1; TERFA
Cell cycle
ABL1; MIS18A; MSH5; HTATIP; CDK5RAP2; ARPP19A; RAD21; RAD21B; YWHAE2; CETN2
Class I PI3K signaling events
ARF1; ITK; PLEKHA1; BLK; ADAP1
Clathrin derived vesicle budding
TPD52L1; CTSZ; SNAPIN; SNX9; CLTB; BLOC1S6; AP3S1; AP1M2; TPD52; CLTA
Disease
AP2M1; ELL; PRELP; MIB1; PACS1; CFTR; PPIAL4A; CDK9; HMGA1; TTR

Protein Function

ARF1 has several biochemical functions, for example, GDP binding, GTP binding, GTPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ARF1 itself. We selected most functions ARF1 had, and list some proteins which have the same functions with ARF1. You can find most of the proteins on our site.
Function
Related Protein
Function GDP binding
Related Protein ARF1; RAB8A; RHOB; GNAI1; KRAS; RAP2C; PCK1; RAB17; ARL2; RAB31
Function GTP binding
Related Protein EHD1B; RAP1B; RAB11A; SEPT10; ARL3L1; NPR2; MTIF2; SEPT7; GNA15.4; RAC3B
Function GTPase activity
Related Protein TUBB6; RAB18B; EIF2S3; IIGP1; CDC42; ARL8B; RAB11B; EIF2S3Y; GSPT2; RRAGD
Function magnesium ion binding
Related Protein DOM3Z; PPM1NB; PRPS1A; NEK6; FOXK2; TSSK3; ENO2; PKM; SPHK1; PKLR
Function phospholipase D activator activity
Related Protein ARF1
Function poly(A) RNA binding
Related Protein HLTF; RPS28; YWHAE; HNRNPDL; SF1; TDRD9; TRIM56; RPF2; MRPS14; RPS17
Function protein binding
Related Protein HEBP2; YWHAE; ELOVL6; TPD52L1; POLM; FASN; KISS1; AKAP7; INTS5; ITGAL
Function receptor signaling protein activity
Related Protein RGS12; GNAZ; IFITM1; DOK1; FCGR1A; NCR1; FLRT1; CD19; DCLK1; SMAD1

Interacting Protein

ARF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARF1.
CYTH2; 1-phosphatidyl-1d-myo-inositol 3,5-bisphosphate; 1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate; SPAG9; ASAP1; GEA1; Asap1; Asap1; Kif1c; MYC; Bach1; AP1B1; Proser1

ARF1 Related Articles

Richards, AL; Soares-Martins, JAP; et al. Generation of Unique Poliovirus RNA Replication Organelles. MBIO 5:-(2014).
Hehnly, H; Xu, WD; et al. Cdc42 Regulates Microtubule-Dependent Golgi Positioning. TRAFFIC 11:1067-1078(2010).