ARFGAP1
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Official Full Name
ADP-ribosylation factor GTPase activating protein 1
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Overview
The protein encoded by this gene is a GTPase-activating protein (GAP) which associates with the Golgi apparatus and which interacts with ADP-ribosylation factor 1 (ARF1). The encoded protein promotes hydrolysis of ARF1-bound GTP and is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles. Dissociation of the coat proteins is required for the fusion of these vesicles with target compartments. The activity of this protein is stimulated by phosphoinosides and inhibited by phosphatidylcholine. Two transcript variants encoding different isoforms have been found for this gene. -
Synonyms
ARFGAP1; ADP-ribosylation factor GTPase activating protein 1; ADP ribosylation factor 1 GTPase activating protein , ARF1GAP; ADP-ribosylation factor GTPase-activating protein 1; bA261N11.3; FLJ10767; ARF1 GAP; ARF GAP 1; GAP protein; ARF1-directed GTPase-;
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- His
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- Involved Pathway
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- Interacting Protein
- ARFGAP1 Related Articles
ARFGAP1 involved in several pathways and played different roles in them. We selected most pathways ARFGAP1 participated on our site, such as Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARFGAP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Endocytosis | ZFYVE27;RHOAC;RAB11AL;RAB11FIP3;WASH;CXCR4A;ADRB3B;RAB35;VPS4B |
ARFGAP1 has several biochemical functions, for example, GTPase activator activity, metal ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARFGAP1 itself. We selected most functions ARFGAP1 had, and list some proteins which have the same functions with ARFGAP1. You can find most of the proteins on our site.
Function | Related Protein |
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GTPase activator activity | ARHGAP40;TBC1D22B;ARHGAP42A;ADAP2;BAI3;WNT11;RASAL1;GAPVD1;RGS3 |
metal ion binding | ZNF26;TRIM71;ZNF624;CHEK2;SHRPRBCK1R;POLL;ZNF718;NAIP7;PLEKHM1 |
protein binding | PABPC1;AHI1;FAM64A;DULLARD;EXOC8;CD99L2;LGALS8;CYTH1;MIS18A |
ARFGAP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARFGAP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARFGAP1.
GRN; TRIM23; KRTAP10-9; GABARAPL2; FOS; KRTAP9-2; KRTAP3-2
- Q&As
- Reviews
Q&As (15)
Ask a questionARFGAP1 plays a critical role in membrane trafficking pathways within cells. It regulates the formation and budding of transport vesicles from the Golgi apparatus, involved in the retrograde transport of molecules between the Golgi and endosomes, and in the recycling of membrane proteins. ARFGAP1 also contributes to the maintenance of Golgi morphology and function.
Dysregulation of ARFGAP1 has been associated with cancer progression. It can affect the trafficking of molecules involved in cell growth, proliferation, and invasion, leading to the promotion of tumor development and metastasis. Additionally, ARFGAP1 may interact with other proteins involved in cell cycle control and cell signaling pathways implicated in cancer.
The role of ARFGAP1 as a tumor suppressor or an oncogene is context-dependent and can vary depending on the type of cancer. In some cancers, ARFGAP1 expression is downregulated or lost, suggesting a potential tumor suppressor role. On the other hand, in certain cancer types, increased ARFGAP1 expression has been associated with cancer progression and poor prognosis, indicating an oncogenic role. Further studies are needed to fully elucidate the underlying mechanisms and determine the precise role of ARFGAP1 in different cancer contexts.
Yes, ARFGAP1 has been shown to interact with other signaling pathways. For example, it has been implicated in the regulation of the Wnt signaling pathway by modulating the stability of Dvl2 protein, a key component of the pathway. ARFGAP1 may also interact with other cellular signaling pathways, although further research is necessary to fully understand these interactions.
ARFGAP1 has shown promise as a potential therapeutic target, especially in diseases associated with abnormal vesicular trafficking, such as certain types of cancer. By modulating ARFGAP1 activity or targeting its interacting proteins, it may be possible to disrupt pathological cellular processes and inhibit disease progression. However, more research is necessary to better understand the precise mechanisms of ARFGAP1 involvement in various diseases and to develop effective and specific therapeutic strategies.
Yes, mutations in the ARFGAP1 gene have been linked to certain forms of central centrifugal cicatricial alopecia and some cases of hereditary spastic paraplegia, which are neurological disorders affecting movement and sensation.
ARFGAP1 interacts with various components of the COPI (coat protein complex I) and COPII (coat protein complex II) vesicular trafficking complexes, as well as with other proteins involved in intracellular transport, such as clathrin and Rab GTPases.
Currently, there are no approved drugs specifically targeting ARFGAP1. However, research is ongoing to develop small molecule inhibitors or other compounds that can modulate its activity as a potential therapeutic strategy.
The expression of ARFGAP1 can be regulated at the transcriptional level through the binding of various transcription factors to its promoter region. Additionally, post-transcriptional regulation and protein degradation pathways can influence its abundance within the cell.
Yes, ARFGAP1 is a highly conserved protein and can be found in various organisms across different species, including mammals, birds, reptiles, amphibians, and even invertebrates like fruit flies and worms.
The ARFGAP1 protein was discovered through biochemical and molecular biology techniques. Researchers were investigating the mechanisms of intracellular vesicular trafficking and identified ARFGAP1 as a protein that regulates the activity of ADP-ribosylation factors (ARFs).
Dysregulation of ARFGAP1 can have various consequences on intracellular vesicular trafficking processes. It can affect the formation and dynamics of coated vesicles, impair Golgi apparatus function, and disrupt endosome-to-Golgi retrograde transport. ARFGAP1 dysregulation has been associated with diseases such as cancer and neurodegenerative disorders.
ARFGAP1 has emerged as a potential therapeutic target for certain diseases, particularly cancer and neurodegenerative disorders. Modulating its activity could help regulate intracellular vesicular trafficking and potentially alleviate associated pathological conditions. However, further research is needed to explore the therapeutic potential and develop specific inhibitors or activators.
Currently, there are no specific inhibitors of ARFGAP1 activity available for clinical use. However, there have been efforts to develop small molecules or peptides that can selectively inhibit ARFGAP1 function as a potential strategy for therapeutic intervention. These inhibitors aim to disrupt the interaction between ARFGAP1 and its target proteins involved in vesicular trafficking, thereby modulating cellular processes influenced by ARFGAP1 activity.
Yes, mutations in the ARFGAP1 gene have been identified in certain human diseases. For example, mutations in ARFGAP1 have been reported in individuals with autosomal recessive perisylvian polymicrogyria, a rare brain malformation disorder characterized by abnormal folding and development of the cerebral cortex. These mutations result in functional changes or loss of ARFGAP1 protein, leading to abnormal neuronal migration during brain development.
Customer Reviews (8)
Write a reviewCoupled with the exceptional technical support provided by the manufacturer, my experience with the ARFGAP1 Protein has been truly outstanding.
They actively seek feedback and incorporate it into their product development process, continuously improving the quality and performance of the ARFGAP1 protein.
The team has been exceptionally knowledgeable and responsive, promptly addressing any inquiries or issues that have arisen during my work.
I highly recommend it to fellow researchers looking for a high-quality protein and excellent technical assistance.
This commitment to excellence ensures that researchers are provided with the most advanced and reliable tools for their investigations.
Whether it's troubleshooting experimental issues, providing guidance on experimental design, or answering any inquiries related to the ARFGAP1 protein, the manufacturer is committed to helping researchers overcome challenges and achieve their scientific goals.
the technical support provided by the manufacturer is extraordinary.
The manufacturer also values customer satisfaction and strives to maintain a strong relationship with researchers.
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