arfgap1
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  • Official Full Name
  • ADP-ribosylation factor GTPase activating protein 1
  • Background
  • The protein encoded by this gene is a GTPase-activating protein (GAP) which associates with the Golgi apparatus and which interacts with ADP-ribosylation factor 1 (ARF1). The encoded protein promotes hydrolysis of ARF1-bound GTP and is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles. Dissociation of the coat proteins is required for the fusion of these vesicles with target compartments. The activity of this protein is stimulated by phosphoinosides and inhibited by phosphatidylcholine. Two transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • ARFGAP1; ADP-ribosylation factor GTPase activating protein 1; ADP ribosylation factor 1 GTPase activating protein , ARF1GAP; ADP-ribosylation factor GTPase-activating protein 1; bA261N11.3; FLJ10767; ARF1 GAP; ARF GAP 1; GAP protein; ARF1-directed GTPase-
Cat.#:ARFGAP1-750HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ARFGAP1 protein, GST-tagged
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Cat.#:ARFGAP1-1843MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse ARFGAP1 Protein
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Cat.#:ARFGAP1-753RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat ARFGAP1 Protein
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Cat.#:ARFGAP1-381RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey ARFGAP1 Protein, His-tagged
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Cat.#:ARFGAP1-2551CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken ARFGAP1
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Cat.#:ARFGAP1-1696ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish ARFGAP1
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Cat.#:ARFGAP1-8754HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human ARFGAP1 293 Cell Lysate
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Cat.#:ARFGAP1-8755HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human ARFGAP1 293 Cell Lysate
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Involved Pathway

ARFGAP1 involved in several pathways and played different roles in them. We selected most pathways ARFGAP1 participated on our site, such as Endocytosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with ARFGAP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Endocytosis
CAPZA2; RAB11A; PIP5K1AB; AGAP1; IST1; ASAP2A; ARF1L; ACAP2; ADRB2B; PIP5K1B

Protein Function

ARFGAP1 has several biochemical functions, for example, GTPase activator activity, metal ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ARFGAP1 itself. We selected most functions ARFGAP1 had, and list some proteins which have the same functions with ARFGAP1. You can find most of the proteins on our site.
Function
Related Protein
Function GTPase activator activity
Related Protein ARHGAP4A; SIPA1L1; RAP1GAP2; ARHGAP32; ASAP3; ALDH1A2; RGS12; TSC2; RGS2; USP6NL
Function metal ion binding
Related Protein ADK; EXT1C; ZBED5; ATP13A; NR1D4A; UBR1; SMAD9; ZNF624; F13A1; CYBB
Function protein binding
Related Protein TFDP2; AGPAT4; SP4; TUBGCP4; EIF4G2; ZNF232; SOX2; CSNK2B; CDAN1; CCDC70

Interacting Protein

ARFGAP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ARFGAP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of ARFGAP1.
GRN; TRIM23; KRTAP10-9; GABARAPL2; FOS; KRTAP9-2; KRTAP3-2

ARFGAP1 Related Articles

Wonderlich, ER; Leonard, JA; et al. ADP Ribosylation Factor 1 Activity Is Required To Recruit AP-1 to the Major Histocompatibility Complex Class I (MHC-I) Cytoplasmic Tail and Disrupt MHC-I Trafficking in HIV-1-Infected Primary T Cells. JOURNAL OF VIROLOGY 85:12216-12226(2011).
Saeki, N; Tokuo, H; et al. BIG1 is a binding partner of myosin IXb and regulates its Rho-GTPase activating protein activity. JOURNAL OF BIOLOGICAL CHEMISTRY 280:10128-10134(2005).